7-nitroindazole has been researched along with Idiopathic Parkinson Disease in 13 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with mangiferin and 7-NI significantly increases locomotor parameters in 6-OHDA lesioned rats." | 1.72 | Effects of mangiferin and its combination with nNOS inhibitor 7-nitro-indazole (7-NI) in 6-hydroxydopamine (6-OHDA) lesioned Parkinson's disease rats. ( Chaudhary, MJ; Nath, R; Pal, R; Tiwari, PC, 2022) |
| "Chronic L-DOPA pharmacotherapy in Parkinson's disease is often accompanied by the development of abnormal and excessive movements known as L-DOPA-induced dyskinesia." | 1.35 | Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease. ( Del-Bel, EA; Echeverry, MB; Padovan-Neto, FE; Tumas, V, 2009) |
| "The neuropathological hallmark of Parkinson's disease (PD) is the selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc)." | 1.33 | 7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study. ( Benigno, A; Crescimanno, G; Di Giovanni, G; Di Matteo, V; Esposito, E; Giuliano, DA; Pierucci, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Tiwari, PC | 1 |
| Chaudhary, MJ | 1 |
| Pal, R | 1 |
| Nath, R | 1 |
| Herrero, MT | 1 |
| Yuste, JE | 1 |
| Cuenca-Bermejo, L | 1 |
| Almela, P | 1 |
| Arenas-Betancur, L | 1 |
| De Pablos, V | 1 |
| Gonzalez-Cuello, A | 1 |
| Del Bel, E | 1 |
| Navarro-Zaragoza, J | 1 |
| Fernández-Villalba, E | 1 |
| Solís, O | 1 |
| Espadas, I | 1 |
| Del-Bel, EA | 2 |
| Moratalla, R | 1 |
| Bortolanza, M | 2 |
| Cavalcanti-Kiwiatkoski, R | 1 |
| Padovan-Neto, FE | 2 |
| da-Silva, CA | 2 |
| Mitkovski, M | 1 |
| Raisman-Vozari, R | 1 |
| Del-Bel, E | 2 |
| Kumari, R | 1 |
| Kumar, JB | 1 |
| Luthra, PM | 1 |
| Bariotto-Dos-Santos, KD | 1 |
| Dos-Santos-Pereira, M | 1 |
| Di Matteo, V | 2 |
| Pierucci, M | 2 |
| Benigno, A | 2 |
| Crescimanno, G | 2 |
| Esposito, E | 2 |
| Di Giovanni, G | 2 |
| Echeverry, MB | 1 |
| Tumas, V | 1 |
| Giuliano, DA | 1 |
| Rajakumar, B | 1 |
| Flumerfelt, BA | 1 |
| Hrycyshyn, AW | 1 |
| Rajakumar, N | 1 |
| Haik, KL | 1 |
| Shear, DA | 1 |
| Hargrove, C | 1 |
| Patton, J | 1 |
| Mazei-Robison, M | 1 |
| Sandstrom, MI | 1 |
| Dunbar, GL | 1 |
| Przedborski, S | 1 |
| Jackson-Lewis, V | 1 |
| Yokoyama, R | 1 |
| Shibata, T | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Snyder, SH | 1 |
13 other studies available for 7-nitroindazole and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Effects of mangiferin and its combination with nNOS inhibitor 7-nitro-indazole (7-NI) in 6-hydroxydopamine (6-OHDA) lesioned Parkinson's disease rats.
Topics: Animals; Male; Nitrites; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2022 |
7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate.
Topics: Animals; Antiparkinson Agents; Dyskinesia, Drug-Induced; Levodopa; Parkinson Disease; Parkinsonian D | 2023 |
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
Topics: Animals; Antiparkinson Agents; Benserazide; Cell Count; Corpus Striatum; Disease Models, Animal; Dop | 2015 |
Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Indazoles; Inflamma | 2015 |
Post-lesion administration of 7-NI attenuated motor and non-motor deficits in 6-OHDA induced bilaterally lesioned female rat model of Parkinson's disease.
Topics: Animals; Brain; Catalase; Dopamine; Female; Glutathione; Indazoles; Lipid Peroxidation; Motor Skills | 2015 |
Antidyskinetic Effect of 7-Nitroindazole and Sodium Nitroprusside Associated with Amantadine in a Rat Model of Parkinson's Disease.
Topics: Amantadine; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Dyskinesia, | 2016 |
Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: a neurochemical study .
Topics: Animals; Corpus Striatum; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidopami | 2009 |
Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; En | 2009 |
7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Indazoles | 2006 |
Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Choline; Disease Models, Animal; Female; In | 2007 |
7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Indazoles; Learni | 2008 |
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebellum; Corpus Striatum; Dopamine; Dopamine Agents; Enz | 1996 |
No NO prevents parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Enzyme Inhi | 1996 |