7-nitroindazole has been researched along with Epilepsy in 9 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ascorbic acid and nitric oxide are known to play important roles in epilepsy." | 3.76 | Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity. ( Agar, E; Ayyildiz, M; Yildirim, M, 2010) |
| "In order to investigate the effect of 7-nitroindazole (7-NI) on penicillin-induced epilepsy and the relationship between NO and anti-epileptic effect of electro-acupuncture, computerized physiological polygraph and NO-sensitive electrode with potentiostat were respectively used to record the total power spectrum (TPS) of EEG and the concentration of NO in rat hippocampus pretreated with electro-acupuncture or 7-NI for 30 min before penicillin." | 3.70 | [Effect of electroacupuncture and 7-NI on penicillin-induced epilepsy and their relation with intrahippocampal NO changes]. ( Chen, G; Cheng, JS; Huang, ZN; Yang, R, 1999) |
| "Depression is the most common psychiatric comorbidity of epilepsy." | 1.62 | Chronically altered NMDAR signaling in epilepsy mediates comorbid depression. ( Dehpour, AR; Hemmati, S; Mohammadi, S; Sadeghi, MA; Vafaei, A; Yousefi-Manesh, H; Zare, M, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Sadeghi, MA | 1 |
| Hemmati, S | 1 |
| Mohammadi, S | 1 |
| Yousefi-Manesh, H | 1 |
| Vafaei, A | 1 |
| Zare, M | 1 |
| Dehpour, AR | 1 |
| Aslan, A | 1 |
| Yildirim, M | 3 |
| Ayyildiz, M | 3 |
| Güven, A | 1 |
| Agar, E | 3 |
| de Vasconcelos, AP | 1 |
| Bouilleret, V | 1 |
| Riban, V | 1 |
| Wasterlain, C | 1 |
| Nehlig, A | 1 |
| Bosnak, M | 1 |
| Smith, SE | 1 |
| Man, CM | 1 |
| Yip, PK | 1 |
| Tang, E | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Yasuda, H | 1 |
| Fujii, M | 1 |
| Fujisawa, H | 1 |
| Ito, H | 1 |
| Suzuki, M | 1 |
| Lu, W | 1 |
| Chen, G | 2 |
| Cheng, JS | 2 |
| Huang, ZN | 1 |
| Yang, R | 1 |
9 other studies available for 7-nitroindazole and Epilepsy
| Article | Year |
|---|---|
Chronically altered NMDAR signaling in epilepsy mediates comorbid depression.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Depression; Epilepsy; Fluoxetine; Indazoles; Male; | 2021 |
The role of nitric oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform activity in rat.
Topics: Action Potentials; Animals; Anticonvulsants; Electrophysiology; Epilepsy; Ghrelin; Indazoles; Inject | 2009 |
Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity.
Topics: Analysis of Variance; Animals; Antioxidants; Arginine; Ascorbic Acid; Disease Models, Animal; Dose-R | 2010 |
Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches.
Topics: Animals; Antipyrine; Brain; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Disease Model | 2005 |
The role of nitric oxide in the anticonvulsant effects of pyridoxine on penicillin-induced epileptiform activity in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Rela | 2007 |
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
Topics: Animals; Anticonvulsants; Arginine; Blood Pressure; Citrulline; Disease Models, Animal; Epilepsy; Fe | 1996 |
Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainate injection.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Lat | 2001 |
[Effect of nitric oxide release on epileptiform discharge in CA1 area of hippocampal slices].
Topics: Animals; Anticonvulsants; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Indazoles; | 1998 |
[Effect of electroacupuncture and 7-NI on penicillin-induced epilepsy and their relation with intrahippocampal NO changes].
Topics: Animals; Anticonvulsants; Brain; Electroacupuncture; Electroencephalography; Epilepsy; Hippocampus; | 1999 |