7-nitroindazole has been researched along with Disease Models, Animal in 90 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 7.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 7.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| "However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated." | 5.31 | 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001) |
| " Therefore, in this study, we combined subchronic fluoxetine (Flx) with 7-nitroindazole (NI), a selective nNOS inhibitor, and evaluated their efficacy against anxiety-related behavior in an animal model of PTSD." | 4.31 | Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine's anxiogenic activity in an animal model of PTSD. ( Chamanara, M; Dehpour, AR; Fekrvand, S; Foroutani, L; Hemmati, S; Hosseini, Y; Nassireslami, E; Sadeghi, MA; Yousefi Zoshk, M; Yousefi-Manesh, H, 2023) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " In addition to anxiety and depressive-like behaviors, we previously showed that juvenile SIS increases susceptibility to pentylenetetrazole (PTZ)-induced seizures in mice through enhancing the nitrergic system activity in the hippocampus." | 3.83 | NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice. ( Amini-khoei, H; Amiri, S; Azizi, R; Dehpour, AR; Ghazi-Khansari, M; Haj-Mirzaian, A; Mehr, SE; Momeny, M; Rahimi-Balaei, M; Shirzadian, A; Zarrinrad, G, 2016) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 3.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| " In order to examine the involvement of nitric oxide (NO) on stress-induced neurobehavioral changes and the concomitant alterations of neuroendocrinological factors, we studied the effects of the nonselective NOS inhibitor, N(ω)-Nitro L-arginine methyl ester hydrochloride (L-NAME) and the specific neuronal NOS inhibitor, 7-nitroindazole (7-NI) on restraint stress-induced anxiety in the elevated plus maze (EPM) test and biochemical analysis." | 3.78 | The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat. ( Her, S; Joung, HY; Jung, EY; Kim, K; Lee, MS; Shim, I, 2012) |
| "Ascorbic acid and nitric oxide are known to play important roles in epilepsy." | 3.76 | Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity. ( Agar, E; Ayyildiz, M; Yildirim, M, 2010) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 3.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| "The present study was performed to assess the prophylactic effect of 7-nitroindazole (7-NI), an inhibitor of neuronal nitric oxide synthase (nNOS), in an animal model of heatstroke." | 3.74 | Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. ( Chang, CP; Cheng, BC; Lee, CC; Lin, MT, 2007) |
| " The aim of this study was to compare the behavioural effects of NOS inhibitor 7-nitroindazole (7-NI) with the more selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)imidazole (TRIM) in animal models predictive of antidepressant- and anxiolytic-like activity in order to clarify the role of distinct isoforms of NOS in the regulation of depression and anxiety." | 3.72 | Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. ( Bourin, M; Vasar, E; Volke, V; Wegener, G, 2003) |
| "The interaction of 7-nitroindazole (7-NI), a nitric oxide synthase (NOS) inhibitor, with the protective activity of conventional antiepileptics against pentylenetetrazol (PTZ)-induced seizures was tested in mice." | 3.70 | 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J, 2000) |
| " Dose-response for each NSAIDs were created before and after 5 mg/kg of L-NAME i." | 1.56 | Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2020) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "In this present study, a rat model of cerebral ischemia and reperfusion by four-vessel occlusion was generated to assess MKK4 S-nitrosylation." | 1.43 | Inhibition on the S-nitrosylation of MKK4 can protect hippocampal CA1 neurons in rat cerebral ischemia/reperfusion. ( Hao, LY; Qi, SH; Wei, XW, 2016) |
| "Pretreatment with gadolinium inhibited the activation of macrophages and the induction of iNOS in intestinal resident macrophages, and restored the number of KIT-positive cells and intestinal contractions." | 1.40 | Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice. ( Koike, M; Matsuda, H; Nishida, T; Sawa, Y; Uchiyama, Y; Ueshima, S, 2014) |
| "Global cerebral ischemia/reperfusion promoted the binding between neuronal nitric oxide synthase (nNOS) and postsynaptic density protein 95 that has been reported to activate nNOS, and GSNO inhibited the post-ischemic nNOS activation and NO release." | 1.39 | Neuroprotection of S-nitrosoglutathione against ischemic injury by down-regulating Fas S-nitrosylation and downstream signaling. ( Hou, XY; Wu, SL; Yan, JZ; Yin, XH; Zhang, GY, 2013) |
| "Nitrite/nitrate (NOx) production in the septic shock stage was much greater than those in the corresponding sham groups, and NOx production in the cytosol by inducible NOS was greater." | 1.38 | Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening. ( Bruce, IC; Wang, H; Xia, Q; Xu, C; Yi, C, 2012) |
| "Electroconvulsions were produced in mice by means of an alternating current (50 Hz, 500 V, 25 mA, ear-clip electrodes, 0." | 1.37 | 7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model. ( Dworzański, W; Jaskólska, A; Zółkowska, D; Łuszczki, JJ, 2011) |
| "Myricitrin did not induce catalepsy in the bar test." | 1.37 | Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models. ( Andreatini, R; Chioca, LR; Correia, D; Pereira, M; Pizzolatti, MG; Santos, AR; Siba, IP; Vital, MA, 2011) |
| "Chronic L-DOPA pharmacotherapy in Parkinson's disease is often accompanied by the development of abnormal and excessive movements known as L-DOPA-induced dyskinesia." | 1.35 | Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease. ( Del-Bel, EA; Echeverry, MB; Padovan-Neto, FE; Tumas, V, 2009) |
| "Levetiracetam was given alone or in combination with 7-nitroindazole, a preferential inhibitor of neuronal nitric oxide synthase, or with L: -arginine, the precursor of nitric oxide synthesis." | 1.35 | In the rat maximal dentate activation model of partial complex epilepsy, the anticonvulsant activity of levetiracetam is modulated by nitric oxide-active drugs. ( Carletti, F; D'Agostino, S; Ferraro, G; Lonobile, G; Rizzo, V; Sardo, P, 2009) |
| " Blood pressure and renal excretion were measured in adulthood, under different sodium conditions, and before and after chronic administration of either N(G)-nitro-l-arginine methyl ester (l-NAME) or l-arginine." | 1.35 | Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals. ( Brown, RD; Carlström, M; Edlund, J; Larsson, E; Palm, F; Persson, AE; Sällström, J; Teerlink, T; Wåhlin, N, 2008) |
| "Vitamin C enhanced the catalepsy produced by NOS inhibitors and Hal." | 1.33 | Combined treatment of ascorbic acid or alpha-tocopherol with dopamine receptor antagonist or nitric oxide synthase inhibitor potentiates cataleptic effect in mice. ( Del Bel, EA; Lazzarini, M; Salum, C, 2005) |
| "Post-traumatic stress disorder (PTSD) may be associated with shrinkage of the hippocampus, with glutamate release causally related to these events." | 1.33 | Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma. ( Bothma, T; Harvey, BH; Nel, A; Stein, DJ; Wegener, G, 2005) |
| "Previous studies have shown that cerebral hypoxia results in increased activity of caspase-9, a key initiator of programmed cell death." | 1.33 | Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. ( Delivoria-Papadopoulos, M; Mishra, OP, 2006) |
| "The neuropathological hallmark of Parkinson's disease (PD) is the selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc)." | 1.33 | 7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study. ( Benigno, A; Crescimanno, G; Di Giovanni, G; Di Matteo, V; Esposito, E; Giuliano, DA; Pierucci, M, 2006) |
| "Riluzole, has previously been shown to be protective in animal models of Parkinson's disease in vivo." | 1.31 | The protective effect of riluzole in the MPTP model of Parkinson's disease in mice is not due to a decrease in MPP(+) accumulation. ( Boireau, A; Bordier, F; Dubedat, P; Imperato, A; Moussaoui, S, 2000) |
| "Tamoxifen has several potential mechanisms of action including inhibition of the release of excitatory amino acids (EAA) and nitric oxide synthase (NOS) activity." | 1.31 | Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat. ( Feustel, PJ; Kimelberg, HK; Mongin, AA; Osuka, K; Tranmer, BI, 2001) |
| "However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated." | 1.31 | 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (10.00) | 18.2507 |
| 2000's | 35 (38.89) | 29.6817 |
| 2010's | 42 (46.67) | 24.3611 |
| 2020's | 4 (4.44) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Sadeghi, MA | 1 |
| Hemmati, S | 1 |
| Yousefi-Manesh, H | 1 |
| Fekrvand, S | 1 |
| Foroutani, L | 1 |
| Nassireslami, E | 1 |
| Yousefi Zoshk, M | 1 |
| Hosseini, Y | 1 |
| Dehpour, AR | 5 |
| Chamanara, M | 1 |
| Abdel-Haq, M | 1 |
| Ojha, SK | 1 |
| Hamoudi, W | 1 |
| Kumar, A | 1 |
| Tripathi, MK | 1 |
| Khaliulin, I | 1 |
| Domb, AJ | 1 |
| Amal, H | 1 |
| Yu, LM | 1 |
| Zhang, TY | 1 |
| Yin, XH | 2 |
| Yang, Q | 1 |
| Lu, F | 1 |
| Yan, JZ | 2 |
| Li, C | 1 |
| Majzunova, M | 2 |
| Kvandova, M | 2 |
| Berenyiova, A | 2 |
| Balis, P | 1 |
| Dovinova, I | 2 |
| Cacanyiova, S | 2 |
| Noriega, V | 1 |
| Miranda, HF | 1 |
| Prieto, JC | 1 |
| Sotomayor-Zárate, R | 1 |
| Sierralta, F | 1 |
| Stanquini, LA | 1 |
| Biojone, C | 1 |
| Guimarães, FS | 2 |
| Joca, SR | 2 |
| Zhang, J | 2 |
| Han, Y | 1 |
| Wang, Y | 1 |
| Cheng, X | 1 |
| Wang, CJ | 1 |
| Hrabárová, E | 1 |
| Jansen, E | 1 |
| Barančík, M | 1 |
| Ding, L | 1 |
| Gao, X | 1 |
| Hu, J | 1 |
| Yu, S | 1 |
| Islas-Espinoza, AM | 1 |
| Campos-Rodriguez, C | 1 |
| San Juan, ER | 1 |
| Lange, M | 1 |
| Hamahata, A | 1 |
| Traber, DL | 1 |
| Nakano, Y | 1 |
| Traber, LD | 1 |
| Enkhbaatar, P | 2 |
| Hou, XY | 1 |
| Wu, SL | 1 |
| Zhang, GY | 1 |
| Makuch, W | 1 |
| Mika, J | 1 |
| Rojewska, E | 1 |
| Zychowska, M | 1 |
| Przewlocka, B | 1 |
| Natarajan, C | 1 |
| Yao, SY | 1 |
| Zhang, F | 1 |
| Sriram, S | 1 |
| Neis, VB | 1 |
| Manosso, LM | 1 |
| Moretti, M | 2 |
| Freitas, AE | 2 |
| Daufenbach, J | 1 |
| Rodrigues, AL | 2 |
| Gilhotra, N | 1 |
| Dhingra, D | 1 |
| Ueshima, S | 1 |
| Nishida, T | 1 |
| Koike, M | 1 |
| Matsuda, H | 1 |
| Sawa, Y | 1 |
| Uchiyama, Y | 1 |
| Kristek, F | 1 |
| Drobna, M | 1 |
| Solís, O | 1 |
| Espadas, I | 1 |
| Del-Bel, EA | 2 |
| Moratalla, R | 1 |
| Bortolanza, M | 3 |
| Cavalcanti-Kiwiatkoski, R | 1 |
| Padovan-Neto, FE | 3 |
| da-Silva, CA | 3 |
| Mitkovski, M | 1 |
| Raisman-Vozari, R | 1 |
| Del-Bel, E | 2 |
| Carletti, F | 2 |
| Gambino, G | 1 |
| Rizzo, V | 2 |
| Ferraro, G | 3 |
| Sardo, P | 3 |
| Holzmann, I | 1 |
| da Silva, LM | 1 |
| Corrêa da Silva, JA | 1 |
| Steimbach, VM | 1 |
| de Souza, MM | 1 |
| Czarnecka, A | 1 |
| Konieczny, J | 1 |
| Lenda, T | 1 |
| Lorenc-Koci, E | 1 |
| Hassanipour, M | 1 |
| Shirzadian, A | 2 |
| Boojar, MM | 1 |
| Abkhoo, A | 2 |
| Delazar, S | 1 |
| Amiri, S | 2 |
| Rahimi, N | 1 |
| Ostadhadi, S | 1 |
| Haj-Mirzaian, A | 1 |
| Amini-khoei, H | 1 |
| Momeny, M | 1 |
| Rahimi-Balaei, M | 1 |
| Zarrinrad, G | 1 |
| Ghazi-Khansari, M | 1 |
| Azizi, R | 1 |
| Mehr, SE | 1 |
| Tan, YF | 1 |
| Liao, ZL | 1 |
| Qiu, YJ | 1 |
| Zhu, JP | 1 |
| Yu, EY | 1 |
| Bariotto-Dos-Santos, KD | 1 |
| Dos-Santos-Pereira, M | 1 |
| Wei, XW | 1 |
| Hao, LY | 1 |
| Qi, SH | 1 |
| Siba, IP | 2 |
| Frazão Vital, MAB | 1 |
| Andreatini, R | 2 |
| da Cunha, JM | 1 |
| Del Bel, EA | 3 |
| Zanoveli, JM | 1 |
| Tian, YH | 1 |
| Lee, KW | 1 |
| You, IJ | 1 |
| Lee, SY | 1 |
| Jang, CG | 1 |
| Echeverry, MB | 2 |
| Tumas, V | 2 |
| Liu, K | 1 |
| Li, Q | 1 |
| Zhang, L | 1 |
| Zheng, X | 1 |
| D'Agostino, S | 1 |
| Lonobile, G | 1 |
| Tesser-Viscaíno, SA | 1 |
| Denadai-Souza, A | 1 |
| Teixeira, SA | 1 |
| Ervolino, E | 1 |
| Cruz-Rizzolo, RJ | 1 |
| Costa, SK | 1 |
| Muscará, MN | 1 |
| Casatti, CA | 1 |
| Yildirim, M | 2 |
| Ayyildiz, M | 2 |
| Agar, E | 2 |
| Huang, XY | 1 |
| Ye, ML | 1 |
| Luo, CX | 2 |
| Wu, HY | 1 |
| Hu, Y | 1 |
| Zhou, QG | 2 |
| Wu, DL | 1 |
| Zhu, LJ | 1 |
| Zhu, DY | 2 |
| Bahremand, A | 2 |
| Nasrabady, SE | 1 |
| Ziai, P | 2 |
| Rahimian, R | 2 |
| Hedayat, T | 2 |
| Payandemehr, B | 2 |
| Khodadad, TK | 1 |
| Ghasemi, A | 1 |
| Ghasemi, M | 1 |
| Novaretti, N | 1 |
| Kunori, S | 1 |
| Matsumura, S | 1 |
| Okuda-Ashitaka, E | 1 |
| Katano, T | 1 |
| Audoly, LP | 1 |
| Urade, Y | 1 |
| Ito, S | 1 |
| Tjong, YW | 1 |
| Ip, SP | 1 |
| Lao, L | 1 |
| Wu, J | 1 |
| Fong, HH | 1 |
| Sung, JJ | 1 |
| Berman, B | 1 |
| Che, CT | 1 |
| Łuszczki, JJ | 1 |
| Jaskólska, A | 1 |
| Dworzański, W | 1 |
| Zółkowska, D | 1 |
| Pereira, M | 1 |
| Chioca, LR | 1 |
| Correia, D | 1 |
| Vital, MA | 1 |
| Pizzolatti, MG | 1 |
| Santos, AR | 1 |
| Budni, J | 1 |
| Fernandes, SC | 1 |
| Balen, Gde O | 1 |
| Xu, C | 1 |
| Yi, C | 1 |
| Wang, H | 1 |
| Bruce, IC | 1 |
| Xia, Q | 1 |
| Ferreira, FR | 1 |
| Oliveira, AM | 1 |
| Dinarte, AR | 1 |
| Pinheiro, DG | 1 |
| Greene, LJ | 1 |
| Silva, WA | 1 |
| Mendes, DA | 1 |
| Horinouchi, CD | 1 |
| Prudente, Ada S | 1 |
| Soley, Bda S | 1 |
| Assreuy, J | 1 |
| Otuki, MF | 1 |
| Cabrini, DA | 1 |
| Yuste, JE | 1 |
| Ros-Bernal, F | 1 |
| Gomez, A | 1 |
| Ros, CM | 1 |
| Campuzano, CM | 1 |
| Fernandez-Villalba, E | 1 |
| Herrero, MT | 1 |
| Joung, HY | 1 |
| Jung, EY | 1 |
| Kim, K | 1 |
| Lee, MS | 1 |
| Her, S | 1 |
| Shim, I | 1 |
| Volke, V | 1 |
| Wegener, G | 2 |
| Bourin, M | 1 |
| Vasar, E | 1 |
| Murakami, K | 1 |
| Shimoda, K | 1 |
| Mizutani, A | 1 |
| McGuire, R | 1 |
| Schmalstieg, F | 1 |
| Cox, R | 1 |
| Hawkins, H | 1 |
| Jodoin, J | 1 |
| Lee, S | 1 |
| Traber, L | 1 |
| Herndon, D | 1 |
| Traber, D | 1 |
| de Vasconcelos, AP | 1 |
| Bouilleret, V | 1 |
| Riban, V | 1 |
| Wasterlain, C | 1 |
| Nehlig, A | 1 |
| Lazzarini, M | 1 |
| Salum, C | 1 |
| Harvey, BH | 1 |
| Bothma, T | 1 |
| Nel, A | 1 |
| Stein, DJ | 1 |
| Li, H | 1 |
| Pin, S | 1 |
| Zeng, Z | 1 |
| Wang, MM | 1 |
| Andreasson, KA | 1 |
| McCullough, LD | 1 |
| Mishra, OP | 2 |
| Delivoria-Papadopoulos, M | 2 |
| Eros, G | 1 |
| Kaszaki, J | 1 |
| Czóbel, M | 1 |
| Boros, M | 1 |
| Mishra, R | 1 |
| Ashraf, QM | 1 |
| Chalimoniuk, M | 1 |
| Lukacova, N | 1 |
| Marsala, J | 1 |
| Langfort, J | 1 |
| Cheng, BC | 1 |
| Chang, CP | 1 |
| Lin, MT | 1 |
| Lee, CC | 1 |
| Serrano, J | 1 |
| Encinas, JM | 1 |
| Fernández, AP | 1 |
| Rodrigo, J | 1 |
| Martínez, A | 1 |
| Di Matteo, V | 1 |
| Benigno, A | 1 |
| Pierucci, M | 1 |
| Giuliano, DA | 1 |
| Crescimanno, G | 1 |
| Esposito, E | 1 |
| Di Giovanni, G | 1 |
| Liu, W | 1 |
| Jin, FG | 1 |
| Qian, GS | 1 |
| Ladino, J | 1 |
| Bancalari, E | 1 |
| Suguihara, C | 1 |
| Bosnak, M | 1 |
| Rajakumar, B | 1 |
| Flumerfelt, BA | 1 |
| Hrycyshyn, AW | 1 |
| Rajakumar, N | 1 |
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| Cai, HH | 1 |
| Sun, YJ | 1 |
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| Jiang, J | 1 |
| Hua, Y | 1 |
| Han, X | 1 |
| Carlström, M | 1 |
| Brown, RD | 1 |
| Edlund, J | 1 |
| Sällström, J | 1 |
| Larsson, E | 1 |
| Teerlink, T | 1 |
| Palm, F | 1 |
| Wåhlin, N | 1 |
| Persson, AE | 1 |
| Yoon, SY | 1 |
| Kwon, YB | 1 |
| Kim, HW | 1 |
| Roh, DH | 1 |
| Seo, HS | 1 |
| Han, HJ | 1 |
| Lee, HJ | 1 |
| Beitz, AJ | 1 |
| Lee, JH | 1 |
| Aoyama, K | 1 |
| Matsumura, N | 1 |
| Watabe, M | 1 |
| Nakaki, T | 1 |
| Yokoyama, H | 1 |
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| Mazei-Robison, M | 1 |
| Sandstrom, MI | 1 |
| Dunbar, GL | 1 |
| Snyder, SH | 1 |
| Hantraye, P | 1 |
| Brouillet, E | 1 |
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| Fouyas, IP | 1 |
| Kelly, PA | 1 |
| Ritchie, IM | 1 |
| Whittle, IR | 1 |
| Paul, R | 1 |
| Koedel, U | 1 |
| Pfister, HW | 1 |
| Nanri, K | 1 |
| Montécot, C | 1 |
| Springhetti, V | 1 |
| Seylaz, J | 1 |
| Pinard, E | 1 |
| Ikeda, K | 1 |
| Iwasaki, Y | 1 |
| Kinoshita, M | 1 |
| Boireau, A | 1 |
| Dubedat, P | 1 |
| Bordier, F | 1 |
| Imperato, A | 1 |
| Moussaoui, S | 1 |
| Imam, SZ | 1 |
| Islam, F | 1 |
| Itzhak, Y | 1 |
| Slikker, W | 1 |
| Ali, SF | 1 |
| Borowicz, KK | 1 |
| Luszczki, J | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Yasuda, H | 1 |
| Fujii, M | 1 |
| Fujisawa, H | 1 |
| Ito, H | 1 |
| Suzuki, M | 1 |
| Osuka, K | 1 |
| Feustel, PJ | 1 |
| Mongin, AA | 1 |
| Tranmer, BI | 1 |
| Kimelberg, HK | 1 |
| Park, WS | 1 |
| Chang, YS | 1 |
| Lee, M | 1 |
90 other studies available for 7-nitroindazole and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine's anxiogenic activity in an animal model of PTSD.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inh | 2023 |
Effects of extended-release 7-nitroindazole gel formulation treatment on the behavior of Shank3 mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Inda | 2023 |
Denitrosylation of nNOS induced by cerebral ischemia-reperfusion contributes to nitrosylation of CaMKII and its inhibition of autophosphorylation in hippocampal CA1.
Topics: Animals; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models | 2019 |
Chronic NOS Inhibition Affects Oxidative State and Antioxidant Response Differently in the Kidneys of Young Normotensive and Hypertensive Rats.
Topics: Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Humans; Hypertensive Retinopathy; In | 2019 |
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Inda | 2020 |
Repeated treatment with nitric oxide synthase inhibitor attenuates learned helplessness development in rats and increases hippocampal BDNF expression.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depr | 2018 |
Neuronal nitric oxide synthase inhibition reduces brain damage by promoting collateral recruitment in a cerebral hypoxia-ischemia mice model.
Topics: Animals; Brain Injuries; Cerebral Cortex; Collateral Circulation; Disease Models, Animal; Hemodynami | 2018 |
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; H | 2018 |
(‑)Epigallocatechin‑3‑gallate attenuates anesthesia‑induced memory deficit in young mice via modulation of nitric oxide expression.
Topics: Anesthesia; Animals; Antioxidants; Apoptosis; Arginine; Biomarkers; Catechin; Disease Models, Animal | 2018 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Heterogeneity of the effects of combined nitric oxide synthase inhibition on organ perfusion in ovine sepsis.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Ileum; Indazoles; Lung Diseases; Nitric | 2013 |
Neuroprotection of S-nitrosoglutathione against ischemic injury by down-regulating Fas S-nitrosylation and downstream signaling.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Caspase 8; Caspase 9; Disease Models, A | 2013 |
Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibi | 2013 |
Activation of NOD2/RIPK2 pathway induces mitochondrial injury to oligodendrocyte precursor cells in vitro and CNS demyelination in vivo.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Corpus Callosum; Demyelinating Diseases; Disease Models, | 2013 |
Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; | 2014 |
Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anxiety; Benzodioxoles; Diazepam; Disease Models, Animal; D | 2014 |
Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice.
Topics: Animals; Disease Models, Animal; Endotoxemia; Gadolinium; Guanidines; Indazoles; Interstitial Cells | 2014 |
Different effects of 7-nitroindazole and L-NAME administered both individually and together on the cardiovascular system of the rat.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiomegaly; Carotid Arteries; Coronary Vessels; Disease | 2015 |
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
Topics: Animals; Antiparkinson Agents; Benserazide; Cell Count; Corpus Striatum; Disease Models, Animal; Dop | 2015 |
Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Indazoles; Inflamma | 2015 |
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dose-Res | 2015 |
Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways.
Topics: Animals; Antidepressive Agents; Antioxidants; Arginine; Behavior, Animal; Disease Models, Animal; Dr | 2015 |
The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Biogenic Monoamines; Brain; Disease Models, Animal; Dopamin | 2015 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response R | 2016 |
Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant-like effect of Wuling mycelia powder in rat.
Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Disease Models, Animal; Dose-Response Relation | 2016 |
Antidyskinetic Effect of 7-Nitroindazole and Sodium Nitroprusside Associated with Amantadine in a Rat Model of Parkinson's Disease.
Topics: Amantadine; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Dyskinesia, | 2016 |
Inhibition on the S-nitrosylation of MKK4 can protect hippocampal CA1 neurons in rat cerebral ischemia/reperfusion.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Disease Models, Animal; Dizocilpine Mal | 2016 |
Fish oil prevents rodent anxious states comorbid with diabetes: A putative involvement of nitric oxide modulation.
Topics: Amygdala; Animals; Anxiety; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzym | 2017 |
7-nitroindazole, nitric oxide synthase inhibitor, attenuates physical dependence on butorphanol in rat.
Topics: Analgesics, Opioid; Animals; Brain; Butorphanol; Cell Count; Disease Models, Animal; Enzyme Inhibito | 2008 |
Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; En | 2009 |
The dynamic detection of NO during stroke and reperfusion in vivo.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Imines; Indazoles; Infusions, Intra | 2009 |
In the rat maximal dentate activation model of partial complex epilepsy, the anticonvulsant activity of levetiracetam is modulated by nitric oxide-active drugs.
Topics: Animals; Anticonvulsants; Arginine; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationshi | 2009 |
Putative antinociceptive action of nitric oxide in the caudal part of the spinal trigeminal nucleus during chronic carrageenan-induced arthritis in the rat temporomandibular joint.
Topics: Animals; Arthralgia; Arthritis, Experimental; Carrageenan; Chronic Disease; Disease Models, Animal; | 2009 |
Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity.
Topics: Analysis of Variance; Animals; Antioxidants; Arginine; Ascorbic Acid; Disease Models, Animal; Dose-R | 2010 |
Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety Disorders; CREB-Binding P | 2010 |
Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclic GMP; Disease Models, Animal; Dose-Response R | 2010 |
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Do | 2010 |
Lack of tolerance for the anti-dyskinetic effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in rats.
Topics: Animals; Anti-Dyskinesia Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; | 2010 |
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord.
Topics: Adenosine Triphosphate; Animals; Cell Movement; Cerebral Cortex; Cinnamates; Dinoprostone; Disease M | 2011 |
Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats.
Topics: Animals; Animals, Newborn; Colon; Colonic Diseases; Disease Models, Animal; Electromyography; Gastro | 2011 |
7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2011 |
Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models.
Topics: Animals; Antipsychotic Agents; Apomorphine; Arginine; Catalepsy; Disease Models, Animal; Dopamine Ag | 2011 |
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test.
Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Ani | 2011 |
Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Indazol | 2012 |
Changes in hippocampal gene expression by 7-nitroindazole in rats submitted to forced swimming stress.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Gene Expression Regulation; Hippocampus | 2012 |
In vivo participation of nitric oxide in hyperproliferative epidermal phenomena in mice.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Cell Proliferation; Croton Oil; Dermatitis | 2012 |
7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inh | 2012 |
The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain; Corticosterone; Disease Models, | 2012 |
Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Argin | 2003 |
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Indazoles; Lu | 2003 |
Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches.
Topics: Animals; Antipyrine; Brain; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Disease Model | 2005 |
Combined treatment of ascorbic acid or alpha-tocopherol with dopamine receptor antagonist or nitric oxide synthase inhibitor potentiates cataleptic effect in mice.
Topics: alpha-Tocopherol; Animals; Ascorbic Acid; Catalepsy; Disease Models, Animal; Dopamine Antagonists; D | 2005 |
Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Hippocampus; Indazoles; Male; NF-kappa B; Nitric Oxide; | 2005 |
Sex differences in cell death.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Drug Interactio | 2005 |
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Brain; Brain Chemistry; Caspase 9; Cas | 2006 |
[Effects of phosphatidylcholine pretreatment during acute experimental biliary reflux].
Topics: Adenosine Triphosphate; Animals; Blood Flow Velocity; Cell Degranulation; Disease Models, Animal; Do | 2005 |
Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cell Death; Cerebral Cortex; Cerebral Infarction; | 2006 |
Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Count; Cyclic GMP; | 2006 |
Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke.
Topics: Animals; Blood Pressure; Body Temperature; Brain Chemistry; Cerebrovascular Disorders; Disease Model | 2007 |
Effects of acute hypobaric hypoxia on the nitric oxide system of the rat cerebral cortex: Protective role of nitric oxide inhibitors.
Topics: Altitude; Analysis of Variance; Animals; Blotting, Western; Calcium; Cerebral Cortex; Disease Models | 2006 |
7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Indazoles | 2006 |
[Effects of 7-nitroindazole on smoke inhalation pulmonary injury].
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Indazoles; Lung; Male; Nitric Oxide; Nitric Oxid | 2007 |
Ventilatory response to hypoxia during endotoxemia in young rats: role of nitric oxide.
Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Female; Hypoxia; Indazoles; Lip | 2007 |
Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat.
Topics: Animals; Anticonvulsants; Arginine; Brain; Dentate Gyrus; Disease Models, Animal; Drug Interactions; | 2007 |
The role of nitric oxide in the anticonvulsant effects of pyridoxine on penicillin-induced epileptiform activity in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Rela | 2007 |
Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Choline; Disease Models, Animal; Female; In | 2007 |
Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression.
Topics: Animals; Brain Infarction; Cell Count; Cell Proliferation; Cyclic AMP Response Element-Binding Prote | 2007 |
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephros | 2008 |
Bee venom injection produces a peripheral anti-inflammatory effect by activation of a nitric oxide-dependent spinocoeruleus pathway.
Topics: Animals; Anti-Inflammatory Agents; Bee Venoms; Disease Models, Animal; Drug Interactions; Enzyme Act | 2008 |
Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Aspartic Acid; Behavior, Animal; Cysteine; Dis | 2008 |
Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Cytoprotectio | 2008 |
7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Indazoles; Learni | 2008 |
No NO prevents parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Enzyme Inhi | 1996 |
Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Disease Model | 1996 |
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
Topics: Animals; Anticonvulsants; Arginine; Blood Pressure; Citrulline; Disease Models, Animal; Epilepsy; Fe | 1996 |
Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Gerbillinae | 1996 |
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy.
Topics: Analysis of Variance; Animals; Blood Pressure; Citrulline; Disease Models, Animal; Dose-Response Rel | 1997 |
Cerebrovascular effects of nitric oxide manipulation in spontaneously hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Blood Pressure; Cereb | 1997 |
7-Nitroindazole inhibits pial arteriolar vasodilation in a rat model of pneumococcal meningitis.
Topics: Animals; Arteries; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Male; Meningitis, Pneumococ | 1997 |
The selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats.
Topics: Animals; Body Temperature; Cell Count; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Indaz | 1998 |
Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 1998 |
The protective effect of riluzole in the MPTP model of Parkinson's disease in mice is not due to a decrease in MPP(+) accumulation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; | 2000 |
Prevention of dopaminergic neurotoxicity by targeting nitric oxide and peroxynitrite: implications for the prevention of methamphetamine-induced neurotoxic damage.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; | 2000 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; | 2000 |
Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainate injection.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Lat | 2001 |
Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Ischemic Atta | 2001 |
7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet.
Topics: Animals; Animals, Newborn; Blood Glucose; Brain Diseases; Cerebral Cortex; Cerebrospinal Fluid; Dise | 2001 |