7-nitroindazole has been researched along with Disease, Pulmonary in 3 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that (1) intraperitoneal injections of Tx2-5 induce a toxic syndrome that include penile erection, hypersalivation and death by respiratory distress or pulmonary edema; (2) pretreatment with the non-selective NOS inhibitor L-NAME reduces the penile erection and partially protects from the lethal effects of Tx2-5; (3) pretreatment with the nNOS-selective inhibitor 7-NI completely abolishes all the toxic effects of Tx2-5, including penile erection and death suggesting that nNOS is the major player in this intoxication; (4) toxins from other animals that affect sodium channels in the same way as Tx2-5 and induce similar toxic syndromes may have as a major common target, the activation of nitric oxide synthases." | 1.32 | Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin. ( Camillo, MA; Troncone, LR; Yonamine, CM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lange, M | 1 |
| Hamahata, A | 1 |
| Traber, DL | 1 |
| Nakano, Y | 1 |
| Traber, LD | 1 |
| Enkhbaatar, P | 2 |
| Murakami, K | 1 |
| Shimoda, K | 1 |
| Mizutani, A | 1 |
| McGuire, R | 1 |
| Schmalstieg, F | 1 |
| Cox, R | 1 |
| Hawkins, H | 1 |
| Jodoin, J | 1 |
| Lee, S | 1 |
| Traber, L | 1 |
| Herndon, D | 1 |
| Traber, D | 1 |
| Yonamine, CM | 1 |
| Troncone, LR | 1 |
| Camillo, MA | 1 |
3 other studies available for 7-nitroindazole and Disease, Pulmonary
| Article | Year |
|---|---|
Heterogeneity of the effects of combined nitric oxide synthase inhibition on organ perfusion in ovine sepsis.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Ileum; Indazoles; Lung Diseases; Nitric | 2013 |
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Indazoles; Lu | 2003 |
Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin.
Topics: Analysis of Variance; Animals; Enzyme Inhibitors; Indazoles; Lung Diseases; Male; Mice; Mice, Inbred | 2004 |