7-nitroindazole has been researched along with Depression in 12 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared the effects of chronic treatment with the preferential nNOS inhibitor 7-nitroindazole (7-NI) with those evoked by the conventional antidepressant fluoxetine on alterations that are considered as markers of depression (immobility in the forced swimming test, FST, decreased body weight gain and increased plasma corticosterone concentration) and cardiovascular changes caused by CVS." | 7.81 | Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats. ( Almeida, J; Crestani, CC; Duarte, JO; Oliveira, LA, 2015) |
| " We compared the effects of chronic treatment with the preferential nNOS inhibitor 7-nitroindazole (7-NI) with those evoked by the conventional antidepressant fluoxetine on alterations that are considered as markers of depression (immobility in the forced swimming test, FST, decreased body weight gain and increased plasma corticosterone concentration) and cardiovascular changes caused by CVS." | 3.81 | Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats. ( Almeida, J; Crestani, CC; Duarte, JO; Oliveira, LA, 2015) |
| "1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol is a novel putative trace amine receptor modulator hypothesized to be useful for treatment-resistant depression." | 3.77 | Antidepressant-like effect of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a putative trace amine receptor ligand involves l-arginine-nitric oxide-cyclic guanosine monophosphate pathway. ( Dhir, A; Kulkarni, SK, 2011) |
| "Depression is the most common psychiatric comorbidity of epilepsy." | 1.62 | Chronically altered NMDAR signaling in epilepsy mediates comorbid depression. ( Dehpour, AR; Hemmati, S; Mohammadi, S; Sadeghi, MA; Vafaei, A; Yousefi-Manesh, H; Zare, M, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sadeghi, MA | 1 |
| Hemmati, S | 1 |
| Mohammadi, S | 1 |
| Yousefi-Manesh, H | 1 |
| Vafaei, A | 1 |
| Zare, M | 1 |
| Dehpour, AR | 1 |
| da Silva Leal, VM | 1 |
| Bonassoli, VT | 1 |
| Soares, LM | 1 |
| Milani, H | 1 |
| de Oliveira, RMW | 1 |
| Stanquini, LA | 1 |
| Biojone, C | 1 |
| Guimarães, FS | 2 |
| Joca, SR | 1 |
| Sasaki-Hamada, S | 1 |
| Nakamura, Y | 1 |
| Koizumi, K | 1 |
| Nabeta, R | 1 |
| Oka, JI | 1 |
| Neis, VB | 1 |
| Manosso, LM | 1 |
| Moretti, M | 2 |
| Freitas, AE | 2 |
| Daufenbach, J | 1 |
| Rodrigues, AL | 2 |
| Almeida, J | 1 |
| Duarte, JO | 1 |
| Oliveira, LA | 1 |
| Crestani, CC | 1 |
| Budni, J | 1 |
| Fernandes, SC | 1 |
| Balen, Gde O | 1 |
| Dhir, A | 1 |
| Kulkarni, SK | 1 |
| Heiberg, IL | 1 |
| Wegener, G | 1 |
| Rosenberg, R | 1 |
| Harkin, A | 1 |
| Connor, TJ | 1 |
| Walsh, M | 1 |
| St John, N | 1 |
| Kelly, JP | 1 |
| Zhou, QG | 1 |
| Hu, Y | 1 |
| Hua, Y | 1 |
| Hu, M | 1 |
| Luo, CX | 1 |
| Han, X | 1 |
| Zhu, XJ | 1 |
| Wang, B | 1 |
| Xu, JS | 1 |
| Zhu, DY | 1 |
| Spiacci, A | 1 |
| Kanamaru, F | 1 |
| Oliveira, RM | 1 |
12 other studies available for 7-nitroindazole and Depression
| Article | Year |
|---|---|
Chronically altered NMDAR signaling in epilepsy mediates comorbid depression.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Depression; Epilepsy; Fluoxetine; Indazoles; Male; | 2021 |
Depletion of 5 hydroxy-triptamine (5-HT) affects the antidepressant-like effect of neuronal nitric oxide synthase inhibitor in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Dose-Response Relationship, Drug; Drug | 2017 |
Repeated treatment with nitric oxide synthase inhibitor attenuates learned helplessness development in rats and increases hippocampal BDNF expression.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depr | 2018 |
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.
Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like | 2019 |
Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; | 2014 |
Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats.
Topics: Animals; Antidepressive Agents; Autonomic Nervous System; Baroreflex; Behavior, Animal; Cardiovascul | 2015 |
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test.
Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Ani | 2011 |
Antidepressant-like effect of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a putative trace amine receptor ligand involves l-arginine-nitric oxide-cyclic guanosine monophosphate pathway.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Biogenic Amines; Brain Chemistry; Cy | 2011 |
Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Cyclic GMP; Depression; Dimethyl Sulfoxide; Enz | 2002 |
Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors.
Topics: Animals; Antidepressive Agents; Depression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imm | 2003 |
Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bromodeoxyuridine; Cell Proliferation; Depression; | 2007 |
Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Arginine; Depression; Dose-Response Re | 2008 |