7-nitroindazole has been researched along with Cerebral Infarction in 6 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to test the hypothesis that the efficacy of 7-nitroindazole (7-NI), a selective neuronal nitric oxide (NO) synthase (NOS) inhibitor, is pH dependent in vivo during focal cerebral ischemia." | 3.72 | Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH? ( Anderson, RE; Coert, BA; Meyer, FB, 2003) |
| "We examined whether 7-nitroindazole (7-NI), a putative inhibitor of neuronal nitric oxide synthase (nNOS), decreases cerebral infarction 24 h after proximal middle cerebral artery (MCA) occlusion." | 3.69 | The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. ( Irikura, K; Limmroth, V; Moskowitz, MA; Yoshida, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coert, BA | 1 |
| Anderson, RE | 1 |
| Meyer, FB | 1 |
| Mishra, OP | 1 |
| Mishra, R | 1 |
| Ashraf, QM | 1 |
| Delivoria-Papadopoulos, M | 1 |
| Yoshida, T | 2 |
| Limmroth, V | 1 |
| Irikura, K | 2 |
| Moskowitz, MA | 2 |
| Dalkara, T | 1 |
| Kamii, H | 1 |
| Mikawa, S | 1 |
| Murakami, K | 1 |
| Kinouchi, H | 1 |
| Yoshimoto, T | 1 |
| Reola, L | 1 |
| Carlson, E | 1 |
| Epstein, CJ | 1 |
| Chan, PH | 1 |
| Tokime, T | 1 |
| Nozaki, K | 1 |
| Sugino, T | 1 |
| Kikuchi, H | 1 |
| Hashimoto, N | 1 |
| Ueda, K | 1 |
6 other studies available for 7-nitroindazole and Cerebral Infarction
| Article | Year |
|---|---|
Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH?
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Enzyme Inhibitors; | 2003 |
Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cell Death; Cerebral Cortex; Cerebral Infarction; | 2006 |
The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels.
Topics: Acetylcholine; Administration, Topical; Amino Acid Oxidoreductases; Animals; Brain; Cerebral Infarct | 1994 |
Dual role of nitric oxide in focal cerebral ischemia.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Brain; Brain Ischemia; Cerebral Infarc | 1994 |
Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Enzyme Inhibitors; Indazoles; Injections, Intraperiton | 1996 |
Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain.
Topics: Animals; Benzamides; Cerebral Infarction; Enzyme Inhibitors; Immunohistochemistry; Indazoles; Ischem | 1998 |