7-nitroindazole has been researched along with Anxiety in 16 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 7.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "The action of the novel nitric oxide synthase (NOS) inhibitor 7-nitroindazole (7-NI) was studied in different exploratory models of anxiety." | 7.69 | 7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety. ( Bourin, M; Kõks, S; Männistö, PT; Soosaar, A; Vasar, E; Volke, V, 1997) |
| " Therefore, in this study, we combined subchronic fluoxetine (Flx) with 7-nitroindazole (NI), a selective nNOS inhibitor, and evaluated their efficacy against anxiety-related behavior in an animal model of PTSD." | 4.31 | Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine's anxiogenic activity in an animal model of PTSD. ( Chamanara, M; Dehpour, AR; Fekrvand, S; Foroutani, L; Hemmati, S; Hosseini, Y; Nassireslami, E; Sadeghi, MA; Yousefi Zoshk, M; Yousefi-Manesh, H, 2023) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 3.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| " In order to examine the involvement of nitric oxide (NO) on stress-induced neurobehavioral changes and the concomitant alterations of neuroendocrinological factors, we studied the effects of the nonselective NOS inhibitor, N(ω)-Nitro L-arginine methyl ester hydrochloride (L-NAME) and the specific neuronal NOS inhibitor, 7-nitroindazole (7-NI) on restraint stress-induced anxiety in the elevated plus maze (EPM) test and biochemical analysis." | 3.78 | The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat. ( Her, S; Joung, HY; Jung, EY; Kim, K; Lee, MS; Shim, I, 2012) |
| "Effects of selective nitric oxide synthase (NOS) inhibitors, 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric oxide synthase (nNOS) and aminoguanidine (AG), a selective inhibitor of inducible nitric oxide synthase (iNOS) on anxiety in unstressed and stressed mice were investigated using elevated plus maze (EPM) test and light-dark test (LDT)." | 3.76 | Differential effects of nitric oxide synthase inhibitors on anxiety in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N; Jain, H, 2010) |
| " The aim of this study was to compare the behavioural effects of NOS inhibitor 7-nitroindazole (7-NI) with the more selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)imidazole (TRIM) in animal models predictive of antidepressant- and anxiolytic-like activity in order to clarify the role of distinct isoforms of NOS in the regulation of depression and anxiety." | 3.72 | Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. ( Bourin, M; Vasar, E; Volke, V; Wegener, G, 2003) |
| "The action of the novel nitric oxide synthase (NOS) inhibitor 7-nitroindazole (7-NI) was studied in different exploratory models of anxiety." | 3.69 | 7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety. ( Bourin, M; Kõks, S; Männistö, PT; Soosaar, A; Vasar, E; Volke, V, 1997) |
| "Treatment with methylene blue did not alter per se any of the behavioral responses measured in the ETM, but blocked the effect promoted by SNP." | 1.36 | Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze. ( Calixto, AV; De Lima, TC; Duarte, FS; Duzzioni, M; Faria, MS; Nascimento Häckl, LP, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Sadeghi, MA | 1 |
| Hemmati, S | 1 |
| Yousefi-Manesh, H | 1 |
| Fekrvand, S | 1 |
| Foroutani, L | 1 |
| Nassireslami, E | 1 |
| Yousefi Zoshk, M | 1 |
| Hosseini, Y | 1 |
| Dehpour, AR | 1 |
| Chamanara, M | 1 |
| Akar, F | 1 |
| Mutlu, O | 1 |
| Komsuoglu Celikyurt, I | 1 |
| Bektas, E | 1 |
| Tanyeri, P | 2 |
| Ulak, G | 3 |
| Erden, F | 2 |
| Gilhotra, N | 2 |
| Dhingra, D | 2 |
| Siba, IP | 1 |
| Bortolanza, M | 1 |
| Frazão Vital, MAB | 1 |
| Andreatini, R | 1 |
| da Cunha, JM | 1 |
| Del Bel, EA | 2 |
| Zanoveli, JM | 1 |
| Calixto, AV | 1 |
| Duarte, FS | 1 |
| Duzzioni, M | 1 |
| Nascimento Häckl, LP | 1 |
| Faria, MS | 1 |
| De Lima, TC | 1 |
| Jain, H | 1 |
| Joung, HY | 1 |
| Jung, EY | 1 |
| Kim, K | 1 |
| Lee, MS | 1 |
| Her, S | 1 |
| Shim, I | 1 |
| Volke, V | 2 |
| Wegener, G | 1 |
| Bourin, M | 2 |
| Vasar, E | 2 |
| Nakashima, MN | 1 |
| Ajiki, K | 1 |
| Nakashima, K | 1 |
| Takahashi, M | 1 |
| Forestiero, D | 1 |
| Manfrim, CM | 1 |
| Guimarães, FS | 3 |
| de Oliveira, RM | 1 |
| Yildiz Akar, F | 1 |
| Utkan, T | 1 |
| Gacar, N | 2 |
| Spolidório, PC | 1 |
| Echeverry, MB | 1 |
| Iyomasa, M | 1 |
| Spiacci, A | 1 |
| Kanamaru, F | 1 |
| Oliveira, RM | 1 |
| Soosaar, A | 1 |
| Kõks, S | 1 |
| Männistö, PT | 1 |
| Ferreira, VM | 1 |
| Valenzuela, CF | 1 |
| Morato, GS | 1 |
| Yildiz, F | 1 |
| Erden, BF | 1 |
16 other studies available for 7-nitroindazole and Anxiety
| Article | Year |
|---|---|
Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine's anxiogenic activity in an animal model of PTSD.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inh | 2023 |
Effects of 7-NI and ODQ on memory in the passive avoidance, novel object recognition, and social transmission of food preference tests in mice.
Topics: Animals; Anxiety; Arginine; Avoidance Learning; Exploratory Behavior; Food Preferences; Indazoles; M | 2014 |
Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anxiety; Benzodioxoles; Diazepam; Disease Models, Animal; D | 2014 |
Fish oil prevents rodent anxious states comorbid with diabetes: A putative involvement of nitric oxide modulation.
Topics: Amygdala; Animals; Anxiety; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzym | 2017 |
Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; C | 2010 |
Differential effects of nitric oxide synthase inhibitors on anxiety in unstressed and stressed mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Darkness; Enzyme Inhibitors; Guanidines; Indazoles; Light; Ma | 2010 |
The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain; Corticosterone; Disease Models, | 2012 |
Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Argin | 2003 |
Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice.
Topics: Animals; Anxiety; Carotid Arteries; Enzyme Inhibitors; Exploratory Behavior; Indazoles; Interpersona | 2003 |
Anxiolytic-like effects induced by nitric oxide synthase inhibitors microinjected into the medial amygdala of rats.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Arginine; Darkness; Enzyme Inhibitors; Indazoles; L | 2006 |
7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats.
Topics: Animals; Anxiety; Arginine; Avoidance Learning; Blood Glucose; Dizocilpine Maleate; Enzyme Inhibitor | 2007 |
Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus.
Topics: Analysis of Variance; Animals; Anxiety; Cyclic GMP; Dentate Gyrus; Dose-Response Relationship, Drug; | 2007 |
Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Arginine; Depression; Dose-Response Re | 2008 |
7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Indazoles; Interpersonal Relations; Male; | 1997 |
Role of nitric oxide-dependent pathways in ethanol-induced anxiolytic effects in rats.
Topics: Animals; Anxiety; Central Nervous System Depressants; Drug Therapy, Combination; Enzyme Inhibitors; | 1999 |
Anxiolytic-like effects of 7-nitroindazole in the rat plus-maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Arginine; Exploratory Behavior; Indazoles; Male; Motor Activi | 2000 |