7-nitroindazole has been researched along with Amyotrophic Lateral Sclerosis in 2 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikeda, K | 1 |
| Iwasaki, Y | 1 |
| Kinoshita, M | 1 |
| Facchinetti, F | 1 |
| Sasaki, M | 1 |
| Cutting, FB | 1 |
| Zhai, P | 1 |
| MacDonald, JE | 1 |
| Reif, D | 1 |
| Beal, MF | 1 |
| Huang, PL | 1 |
| Dawson, TM | 1 |
| Gurney, ME | 1 |
| Dawson, VL | 1 |
2 other studies available for 7-nitroindazole and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 1998 |
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.
Topics: Amidines; Amyotrophic Lateral Sclerosis; Animals; Catalysis; Enzyme Inhibitors; Indazoles; Isoenzyme | 1999 |