7-methoxytacrine has been researched along with Acute Confusional Senile Dementia in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Binder, J; Dohnal, V; Holas, O; Korabecny, J; Kuca, K; Marek, J; Musilek, K; Opletalova, V; Pohanka, M; Zemek, F | 1 |
| Banasova, M; Hamulakova, S; Hrabinova, M; Imrich, J; Janovec, L; Kristian, P; Kuca, K | 1 |
| Bartolini, M; Bolognesi, ML; Guidotti, L; Hrabinova, M; Jeřábek, J; Korábečný, J; Kuča, K; Monti, B; Peña-Altamira, LE; Petralla, S; Roberti, M; Sepsova, V; Soukup, O; Uliassi, E | 1 |
| Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N | 1 |
| Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J | 1 |
| Angeloni, C; Bartolini, M; Bergamini, C; Bolognesi, ML; Chantegreil, F; de Camargo Nascente, L; de Melo Viana Teixeira, S; Freschi, M; Hrelia, S; Malaguti, M; Nachon, F; Prchal, L; Rossi, M; Salerno, A; Soares Romeiro, LA; Soukup, O | 1 |
| Chalupova, K; Gorecki, L; Hepnarova, V; Hrabinova, M; Hroudova, J; Janockova, J; Jun, D; Korabecny, J; Kristofikova, Z; Kucera, T; Kunes, J; Mezeiova, E; Muckova, L; Prchal, L; Soukup, O | 1 |
| Dolezal, R; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Korabecny, J; Kuca, K; Kucera, T; Mezeiova, E; Misik, J; Muckova, L; Pham, NL; Pokrievkova, L; Roh, J; Sepsova, V; Soukup, O; Spilovska, K | 1 |
| Chalupová, K; Korábečný, J; Mžik, M; Palička, V; Šesták, V; Žďárová-Karasová, J | 1 |
| Drtinova, L; Gazova, Z; Horova, A; Korabecny, J; Kral, J; Kuca, K; Musilek, K; Siposova, K; Soukup, O; Spilovska, K | 1 |
| Korabecny, J; Kuca, K; Mzik, M; Nepovimova, E; Palička, V; Voříšek, V; Zdarova Karasova, J | 1 |
| Drtinova, L; Fedunova, D; Gazova, Z; Hamouda, AK; Horak, M; Jost, P; Kaniakova, M; Korabecny, J; Kuca, K; Nepovimova, E; Sepsova, V; Siposova, K; Soukup, O; Spilovska, K; Wang, ZJ | 1 |
| Kassa, J; Kuca, K; Pohanka, M | 1 |
| Bajgar, J; Bisso, GM; Michalek, H | 1 |
| Havel, J; Patocka, J; Vargas, MG | 1 |
| Hroch, M; Karasova-Zdarova, J; Korabecny, J; Mezeiova, E; Mzik, M; Pejchal, J; Sestak, V | 1 |
16 other study(ies) available for 7-methoxytacrine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Models, Molecular; Recombinant Proteins; Structure-Activity Relationship; Tacrine | 2010 |
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Humans; Molecular Docking Simulation; Piperazine; Piperazines; Protein Conformation; Tacrine | 2012 |
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Liver; Molecular Targeted Therapy; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Resveratrol; Stilbenes; Tacrine | 2017 |
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine | 2018 |
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan | 2019 |
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Anacardium; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cell Line; Cell Survival; Cytokines; Drug Design; Humans; Ligands; Lipopolysaccharides; Microglia; Molecular Dynamics Simulation; Neuroprotective Agents; Nuts; Plant Extracts; Structure-Activity Relationship; Tacrine | 2021 |
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Tryptophan | 2021 |
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Enzyme Activation; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrolysis; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Molecular Structure; Permeability; Protein Binding; Structure-Activity Relationship; Tacrine | 2017 |
UHPLC-HRMS study of anti-Alzheimer's drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Hydrolysis; Male; Rats; Rats, Wistar; Tacrine; Tandem Mass Spectrometry; Tryptophan | 2019 |
7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Amantadine; Cholinesterase Inhibitors; Dimerization; Enzyme Assays; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Reference Standards; Tacrine; Thiourea | 2013 |
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Linear Models; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tacrine; Tandem Mass Spectrometry | 2016 |
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amantadine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; CHO Cells; Cholinesterases; Cricetulus; Dimerization; Enzyme Inhibitors; HEK293 Cells; Humans; Molecular Targeted Therapy; Receptor, Muscarinic M1; Receptors, Cholinergic; Receptors, N-Methyl-D-Aspartate; Tacrine; Xenopus | 2017 |
New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine.
Topics: Acetylcholinesterase; Algorithms; Alzheimer Disease; Biosensing Techniques; Cholinesterase Inhibitors; Electrochemistry; Enzymes, Immobilized; Humans; Kinetics; Nootropic Agents; Tacrine | 2008 |
Differential inhibition of rat brain acetylcholinesterase molecular forms by 7-methoxytacrine in vitro.
Topics: Acetylcholinesterase; Alzheimer Disease; Angiotensin-Converting Enzyme Inhibitors; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Molecular Weight; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tacrine | 1995 |
Determination of the anti-Alzheimer's disease drugs tacrine, 7-methoxytacrine, and its metabolites by capillary zone electrophoresis.
Topics: Acetonitriles; Alzheimer Disease; Blood Proteins; Chemical Precipitation; Cholinesterase Inhibitors; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Tacrine | 1998 |
UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Mice | 2022 |