7-methoxy-4-methyl-1-benzopyran-2-one and Fish-Diseases

Diseases caused by rhabdoviruses have had a huge impact on the productive lives of the entire human population. The main problem is the lack of drugs for the treatment of this family of viruses. Infectious hematopoietic necrosis virus (IHNV), the causative agent of IHN, is a typical rhabdovirus which has caused huge losses to the salmonid industry. Therefore, in this study, IHNV was studied as a model to evaluate the antiviral activity of 35 novel coumarin derivatives. Coumarin A9 was specifically selected for further validation studies upon comparing the half maximum inhibitory concentration (IC

Topics: Animals; Antiviral Agents; Apoptosis; Cell Line; Coumarins; Down-Regulation; Fish Diseases; Humans; Oncorhynchus mykiss; Rhabdoviridae; Rhabdoviridae Infections; Structure-Activity Relationship; Survival Rate; Viral Proteins; Virus Internalization