7-hydroxystaurosporine has been researched along with Lung Neoplasms in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Edelman, MJ; Gandara, DR; Gumerlock, PH; Lara, PN; Lau, AH; Mack, PC | 1 |
| Senderowicz, AM | 1 |
| Alley, MC; Dasmahapatra, GP; Didolkar, P; Ghosh, S; Roy, KK; Sausville, EA | 1 |
| Gandara, DR; Goldberg, Z; Gumerlock, PH; Gustafsson, MH; Jones, AA; Mack, PC | 1 |
| Hui, ZG; Li, YX; Yang, WZ; Yu, ZH | 1 |
| Chen, GG; Lee, TW; Li, M; Mok, TS; Xu, H; Yim, AP; Yip, JH | 1 |
| Budworth, J; Courage, C; Gescher, A | 1 |
| Futami, H; Kawakami, K; Takahara, J; Yamaguchi, K | 1 |
| Bradder, SM; Courage, C; Gescher, A; Jones, T; Schultze-Mosgau, MH | 1 |
| Saijo, N | 1 |
| Akinaga, S; Akiyama, T; Courage, C; Gescher, A; Shimizu, M; Sugiyama, K; Tamaoki, T | 1 |
| Jiang, H; Yang, LY | 1 |
| Bowen, C; Edelman, MJ; Gandara, DR; Gelmann, EP; Gumerlock, PH; Mack, PC; Paglieroni, T; Schnier, JB | 1 |
| Fukumoto, H; Fukuoka, K; Kato, H; Koh, Y; Koizumi, F; Kuh, HJ; Nakamura, T; Nishio, K; Saijo, N; Suzuki, T; Tamura, T; Usuda, J | 1 |
| Kuh, HJ; Nakagawa, S; Nishio, K; Saijo, N; Usuda, J; Yamaoka, K | 1 |
| Danenberg, KD; Danenberg, PV; Grem, JL; Kao, V; Nguyen, D | 1 |
| Butler, J; Franklin, WA; Makeyev, Y; Vikram, B; Xiao, HH | 1 |
2 review(s) available for 7-hydroxystaurosporine and Lung Neoplasms
| Article | Year |
|---|---|
Cell cycle modulators for the treatment of lung malignancies.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cyclin-Dependent Kinases; Enzyme Inhibitors; Genes, Retinoblastoma; Humans; Lung Neoplasms; Phosphorylation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2003 |
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Docetaxel; Glucosides; Humans; Irinotecan; Japan; Lung Neoplasms; Mitomycin; Mitomycins; Neoplasms, Experimental; Paclitaxel; Purine Nucleosides; Staurosporine; Taxoids; Treatment Outcome; Vinblastine; Vinorelbine | 1998 |
15 other study(ies) available for 7-hydroxystaurosporine and Lung Neoplasms
| Article | Year |
|---|---|
Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinoma.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cisplatin; Drug Synergism; Humans; Lung Neoplasms; Phosphorylation; Staurosporine; Tumor Cells, Cultured | 2003 |
In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Immunoblotting; Lung Neoplasms; Male; Phosphorylcholine; Prostatic Neoplasms; Signal Transduction; Staurosporine; Time Factors | 2004 |
Enhancement of radiation cytotoxicity by UCN-01 in non-small cell lung carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; G2 Phase; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Staurosporine; Tumor Suppressor Protein p53 | 2004 |
[Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].
Topics: Adenocarcinoma; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; G2 Phase; Genes, p53; Humans; Lung Neoplasms; Mutation; Nasopharyngeal Neoplasms; Particle Accelerators; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 2005 |
Increased inducible nitric oxide synthase in lung carcinoma of smokers.
Topics: Adult; Aged; Aged, 80 and over; Caspase 3; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosamines; S-Nitroso-N-Acetylpenicillamine; Smoking; Staurosporine | 2008 |
Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Isoenzymes; Lung Neoplasms; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line.
Topics: Alkaloids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Line; Cyclin-Dependent Kinases; DNA, Neoplasm; Enzyme Inhibitors; Histones; Humans; Lung Neoplasms; Phosphorylation; Protein Kinase C; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 1996 |
Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine.
Topics: Adenocarcinoma; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Indoles; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1997 |
Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Drug Resistance, Neoplasm; G1 Phase; Humans; Lung Neoplasms; Paclitaxel; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1999 |
Cell cycle checkpoint abrogator UCN-01 inhibits DNA repair: association with attenuation of the interaction of XPA and ERCC1 nucleotide excision repair proteins.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; DNA Repair; DNA Replication; DNA-Binding Proteins; Endonucleases; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Lung Neoplasms; Proteins; Staurosporine; Tumor Cells, Cultured; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 1999 |
RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; G1 Phase; Genes, p53; Genes, Retinoblastoma; Growth Inhibitors; Humans; Lung Neoplasms; Phosphorylation; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells.
Topics: Alkaloids; Antineoplastic Agents; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lung Neoplasms; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 2000 |
A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents.
Topics: Alkaloids; Antineoplastic Agents; Cell Cycle; Cell Division; Computer Simulation; HL-60 Cells; Humans; Jurkat Cells; Kinetics; Lung Neoplasms; Models, Biological; Probability; Reproducibility of Results; Software; Staurosporine | 2000 |
Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Deoxyribonucleotides; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Drug Combinations; Enzyme Inhibitors; Floxuridine; Genes, p53; Humans; Lung Neoplasms; Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines.
Topics: Adenocarcinoma; Alkaloids; Flow Cytometry; G2 Phase; Gamma Rays; Humans; Lung Neoplasms; Mutation; Radiation-Sensitizing Agents; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |