Compounds > 7-hydroxystaurosporine
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7-hydroxystaurosporine and Leukemia

7-hydroxystaurosporine has been researched along with Leukemia in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's6 (66.67)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baer, MR; Bauer, KS; Carroll, M; Fleckinger, S; Gojo, I; Luger, S; Norsworthy, KJ; Perl, A; Sausville, EA; Tidwell, M1
Dent, P; Grant, S; Jia, W; Krystal, G; Rahmani, M; Sausville, EA; Yu, C1
Dent, P; Grant, S; Hahn, M; Li, W; Rahmani, M; Yu, C1
Chen, S; Dai, Y; Dent, P; Grant, S; Khanna, P; Pei, XY1
Carlson, BA; Clark, JL; Sausville, EA; Wang, Q; Worland, PJ1
Chanock, SJ; Hiraoka, W; Nieves-Neira, W; Pommier, Y; Vazquez, N1
Boise, LH; Dent, P; Grant, S; Tang, L1
Dai, Y; Decker, R; Dent, P; Grant, S; Harvey, S; Kramer, L; Schaefer, G; Tang, L1
Dai, Y; Dent, P; Grant, S; McInistry, R; Singh, V; Tang, L; Wang, Z; Yu, C1

Trials

1 trial(s) available for 7-hydroxystaurosporine and Leukemia

ArticleYear
Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome.
    Investigational new drugs, 2013, Volume: 31, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Leukemia; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Middle Aged; Myelodysplastic Syndromes; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Staurosporine; Treatment Outcome; Young Adult

2013

Other Studies

8 other study(ies) available for 7-hydroxystaurosporine and Leukemia

ArticleYear
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
    Blood, 2003, Sep-01, Volume: 102, Issue:5

    Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Benzoquinones; Caspases; Drug Synergism; HL-60 Cells; Humans; Jurkat Cells; Lactams, Macrocyclic; Leukemia; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Rifabutin; Staurosporine; U937 Cells

2003
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:3

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Caspases; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin D1; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Genes, Dominant; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Sirolimus; Staurosporine; Time Factors; U937 Cells

2005
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
    Blood, 2007, May-15, Volume: 109, Issue:10

    Topics: Cell Death; Drug Synergism; HL-60 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Jurkat Cells; Leukemia; Mitogen-Activated Protein Kinase Kinases; Multiple Myeloma; Protein Prenylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Staurosporine; Transfection; Tumor Cells, Cultured; U937 Cells

2007
Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1995, Volume: 6, Issue:8

    Topics: Alkaloids; Amino Acid Sequence; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Leukemia; Maleimides; Molecular Sequence Data; Protein Kinase C; Protein Serine-Threonine Kinases; Staurosporine; Stem Cells; T-Lymphocytes; Tumor Cells, Cultured

1995
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
    The Journal of clinical investigation, 1998, Dec-01, Volume: 102, Issue:11

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Camptothecin; Catalase; Cell Differentiation; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Leukemia; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Neoplasm Proteins; Neutrophils; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Staurosporine; Thiocarbamates; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays

1998
Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).
    Biochemical pharmacology, 2000, Nov-15, Volume: 60, Issue:10

    Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cytarabine; Drug Synergism; Enzyme Inhibitors; Humans; Leukemia; Mitochondria; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Staurosporine; U937 Cells

2000
Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:2

    Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Arabinonucleotides; Blotting, Western; Drug Interactions; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Lymphoma; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Staurosporine; U937 Cells; Vidarabine

2001
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
    Cancer research, 2001, Jul-01, Volume: 61, Issue:13

    Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Butadienes; Caspases; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Jurkat Cells; Leukemia; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Nitriles; Staurosporine; Tumor Cells, Cultured; U937 Cells

2001