7-hydroxystaurosporine has been researched along with Carcinoma, Squamous Cell in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ensley, JF; Gutkind, JS; Igishi, T; Kremer, M; Lahusen, T; Leethanakul, C; Patel, V; Quintanilla-Martinez, L; Sausville, EA; Senderowicz, AM | 1 |
| Hui, ZG; Li, YX; Wu, JX; Yang, WZ; Yu, ZH | 1 |
| Amornphimoltham, P; Benavides, F; Conti, CJ; Gutkind, JS; Molinolo, AA; Patel, V; Sauk, J; Sausville, EA; Sriuranpong, V | 1 |
| Bhawal, UK; Kuniyasu, H; Mitani, Y; Nomura, Y; Otsubo, A; Ozawa, K; Sugiyama, M | 1 |
| Akinaga, S; Gomi, K; Nomura, K; Okabe, M | 1 |
| Akinaga, S; Akiyama, T; Mizukami, T; Okabe, M; Shimizu, M; Tsujita, T; Yoshida, T | 1 |
| Alfieri, AA; Sommers, GM | 1 |
| Akinaga, S; Akiyama, T; Okabe, M; Shimizu, M; Tamaoki, T | 1 |
| Akinaga, S; Akiyama, T; Eastman, A; Shimizu, M; Sugiyama, K; Takahashi, R; Tamaoki, T; Yamaguchi, K | 1 |
| Danenberg, KD; Danenberg, PV; Grem, JL; Kao, V; Nguyen, D | 1 |
10 other study(ies) available for 7-hydroxystaurosporine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
Topics: 3T3 Cells; Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin D3; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Head and Neck Neoplasms; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Inhibitory Concentration 50; Kinetics; Mice; Mice, Nude; Neoplasm Transplantation; Prognosis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; S Phase; Staurosporine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
[Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line].
Topics: Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Survival; G2 Phase; Genes, p53; Humans; Mutation; Nasopharyngeal Neoplasms; Protein Kinase C; Radiation-Sensitizing Agents; Staurosporine | 2003 |
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enzyme Activation; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice; Mouth Mucosa; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin; Staurosporine; Time Factors | 2004 |
UCN-01 (7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primary and metastatic oral cancer cell lines in vitro.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; G1 Phase; Humans; Mouth Neoplasms; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 2007 |
Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; DNA, Neoplasm; Humans; Protein Kinase C; Staining and Labeling; Staurosporine; Time Factors; Tumor Cells, Cultured | 1994 |
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Squamous Cell; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; G1 Phase; Humans; Microtubule-Associated Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Retinoblastoma Protein; RNA, Messenger; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1997 |
Multimodality therapy: radiation and continuous concomitant cis-platinum and PKC inhibition in a cervical carcinoma model.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Enzyme Inhibitors; Female; HeLa Cells; Humans; Protein Kinase C; Radiotherapy Dosage; Spheroids, Cellular; Staurosporine; Tumor Stem Cell Assay; Uterine Cervical Neoplasms | 1998 |
Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycle progression and CDC2/cyclin B1 regulation in A431 cells synchronized at M phase by nocodazole.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Squamous Cell; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell-Free System; Cyclin B; Cyclin B1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Mitosis; Nocodazole; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Skin Neoplasms; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1999 |
UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Damage; Drug Synergism; Female; G2 Phase; Genes, p53; Humans; In Situ Nick-End Labeling; Mitomycin; Protein Kinases; S Phase; Staurosporine; Tumor Cells, Cultured | 2000 |
Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Deoxyribonucleotides; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Drug Combinations; Enzyme Inhibitors; Floxuridine; Genes, p53; Humans; Lung Neoplasms; Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |