Compounds > 7-hydroxystaurosporine
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7-hydroxystaurosporine and Breast Neoplasms

7-hydroxystaurosporine has been researched along with Breast Neoplasms in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (29.17)18.2507
2000's12 (50.00)29.6817
2010's4 (16.67)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Bui, T; Hunt, KK; Keyomarsi, K; Livingston, JA; Mull, BB; Patel, N1
Brown, EJ; Schoppy, DW1
Aft, RL; Cai, S; Ellis, MJ; Goiffon, RJ; Guo, Z; Hoog, J; Li, S; Lin, L; Ma, CX; Piwnica-Worms, H; Prat, A; Ryan, CE; Schaiff, WT1
Chang, J; Di, X; Fan, W; Shen, Y; Sui, M; Zhang, H1
Bernard, PS; Brenin, CM; Cai, SR; Craig Lockhart, A; Creekmore, AN; Dancey, J; Doyle, LA; Ebbert, M; Ellis, MJ; Fracasso, PM; Guo, Z; Ma, CX; Mwandoro, T; Naughton, MJ; Petroni, GR; Picus, J; Piwnica-Worms, H; Pluard, TJ; Reed, J; Ryan, CE; Watson, M; Yarde, ER1
Abe, S; Hashimoto, M; Hosoda, Y; Kitajima, M; Koh, J; Kubota, T; Migita, T1
Blank, DH; Brown, MK; Eastman, A; Gribble, GW; Kohn, EA; Livingstone, M; Rathman, J1
Hashimoto, M; Hosoda, Y; Kitajima, M; Koh, J; Koyama, T; Kubota, T; Migita, T1
Bates, SE; Blayney, M; Mistry, P; Morisaki, K; Polgar, O; Robey, RW; Steadman, K1
Daoud, SS; Mixter, P; Redkar, A1
Dai, Y; Dawson, K; Dent, P; Gilfor, D; Grant, S; Hawkins, W; McKinstry, R; Mitchell, C; Ramakrishnan, V; Roberts, JD; Starkey, J; Yacoub, A1
Franklin, RA; Libra, M; McCubrey, JA; Stivala, F1
Eastman, A; Fanous, AA; Poh, A; Zhang, WH1
Kaur, G; Sausville, EA; Sebers, S; Seynaeve, CM; Stetler-Stevenson, M; Worland, PJ1
Budworth, J; Courage, C; Gescher, A1
Budworth, J; Davies, R; Ferry, DR; Gant, TW; Gescher, A; Malkhandi, J1
Nieves-Neira, W; Pommier, Y1
Brown, MK; Eastman, A; Lee, SI1
Chen, X; Keyomarsi, K; Lowe, M1
Clements, MK; Daoud, SS; Jones, CB; Wasi, S1
Akinaga, S; Akiyama, T; Eastman, A; Shimizu, M; Sugiyama, K; Takahashi, R; Tamaoki, T; Yamaguchi, K1
Tsuchida, E; Tsuchida, M; Urano, M1
Clements, MK; Daoud, SS; Jones, CB; Redkar, A1
Abe, S; Akinaga, S; Akiyama, T; Furukawa, T; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Watanabe, M1

Trials

1 trial(s) available for 7-hydroxystaurosporine and Breast Neoplasms

ArticleYear
A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.
    Breast cancer research and treatment, 2013, Volume: 137, Issue:2

    Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Female; Genes, p53; Humans; Irinotecan; Leukocytes, Mononuclear; Middle Aged; Mutation; Ribosomal Protein S6; Staurosporine; Treatment Outcome

2013

Other Studies

23 other study(ies) available for 7-hydroxystaurosporine and Breast Neoplasms

ArticleYear
Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells against cytotoxic chemotherapy in breast cancer.
    British journal of cancer, 2020, Volume: 122, Issue:6

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cytostatic Agents; Female; G1 Phase; Humans; Mice; Mice, Nude; Staurosporine

2020
Chk'ing p53-deficient breast cancers.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:4

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Checkpoint Kinase 1; Female; Humans; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Thiophenes; Tumor Suppressor Protein p53; Urea

2012
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; DNA Damage; DNA, Neoplasm; Female; Genes, cdc; Genes, erbB-2; Genes, p53; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Kinases; Receptors, Estrogen; Receptors, Progesterone; Staurosporine; Thiophenes; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays

2012
G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2012, Volume: 104, Issue:2

    Topics: Analysis of Variance; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Death; Cell Division; Cell Line, Tumor; Chemoradiotherapy; DNA Fragmentation; Female; Flow Cytometry; G2 Phase Cell Cycle Checkpoints; Humans; Microtubules; Paclitaxel; Prohibitins; Radiation, Ionizing; Staurosporine; Tumor Cells, Cultured; Vincristine

2012
UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction.
    Breast cancer (Tokyo, Japan), 2002, Volume: 9, Issue:1

    Topics: Alkaloids; Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Estrogens; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured

2002
A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:12

    Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Carbazoles; Cell Cycle; Cell Division; Cisplatin; DNA; DNA Damage; Dose-Response Relationship, Drug; Female; Flow Cytometry; G2 Phase; Genes, p53; Humans; Immunoblotting; Indoles; Models, Chemical; Mutation; Protein Binding; S Phase; Staurosporine; Time Factors; Tumor Cells, Cultured

2002
Combined antitumor activity of 7-hydroxystaurosporine (UCN-01) and tamoxifen against human breast carcinoma in vitro and in vivo.
    Breast cancer (Tokyo, Japan), 2003, Volume: 10, Issue:3

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mice; Mice, Inbred BALB C; Staurosporine; Tamoxifen

2003
Pheophorbide a is a specific probe for ABCG2 function and inhibition.
    Cancer research, 2004, Feb-15, Volume: 64, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Chlorophyll; Drug Resistance, Neoplasm; Humans; Irinotecan; Neoplasm Proteins; Quinolines; Staurosporine; Topotecan

2004
Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
    Journal of experimental therapeutics & oncology, 2004, Volume: 4, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Breast; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Proliferation; Epithelial Cells; Female; Genes, p53; Humans; Staurosporine; Topotecan; Tumor Cells, Cultured

2004
Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
    Cancer biology & therapy, 2005, Volume: 4, Issue:11

    Topics: Apoptosis; Benzamides; Breast Neoplasms; Cell Death; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Female; Humans; Mitogen-Activated Protein Kinase Kinases; Protein Kinase Inhibitors; Staurosporine

2005
Two targets are better than one. Promising combination therapy to treat breast cancer.
    Cancer biology & therapy, 2005, Volume: 4, Issue:11

    Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cell Line, Tumor; Drug Therapy, Combination; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Protein Kinase Inhibitors; Receptor, ErbB-2; Signal Transduction; Staurosporine

2005
DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2.
    Cell cycle (Georgetown, Tex.), 2008, Jun-01, Volume: 7, Issue:11

    Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA Primers; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Staurosporine

2008
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
    Cancer research, 1993, May-01, Volume: 53, Issue:9

    Topics: Alkaloids; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Growth Inhibitors; Humans; In Vitro Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Time Factors; Tumor Cells, Cultured; Tyrosine

1993
Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation.
    British journal of cancer, 1995, Volume: 71, Issue:4

    Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Isoenzymes; Lung Neoplasms; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured

1995
Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.
    British journal of cancer, 1996, Volume: 73, Issue:9

    Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Division; Cell Line; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; Maleimides; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine

1996
Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways.
    International journal of cancer, 1999, Jul-30, Volume: 82, Issue:3

    Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Caspase Inhibitors; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Neoplasm Proteins; Nuclear Proteins; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Staurosporine; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines.
    Biochemical pharmacology, 1999, Dec-01, Volume: 58, Issue:11

    Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cisplatin; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Staurosporine; Tumor Cells, Cultured

1999
UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent.
    Oncogene, 1999, Oct-07, Volume: 18, Issue:41

    Topics: Alkaloids; Antineoplastic Agents; Breast; Breast Neoplasms; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Female; G1 Phase; Growth Inhibitors; Humans; Neoplasm Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Tumor Suppressor Protein p53

1999
Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:3

    Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Cattle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; G2 Phase; Humans; S Phase; Staurosporine; Tumor Cells, Cultured

2000
UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
    International journal of cancer, 2000, Mar-01, Volume: 85, Issue:5

    Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Damage; Drug Synergism; Female; G2 Phase; Genes, p53; Humans; In Situ Nick-End Labeling; Mitomycin; Protein Kinases; S Phase; Staurosporine; Tumor Cells, Cultured

2000
Synergistic cytotoxicity between a protein kinase C inhibitor, UCN-01, and monoclonal antibody to the epidermal growth factor receptor on MDA-468 cells.
    Cancer biotherapy & radiopharmaceuticals, 1997, Volume: 12, Issue:2

    Topics: Alkaloids; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Breast Neoplasms; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Mice; Protein Kinase C; Staurosporine; Tumor Cells, Cultured

1997
UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells.
    International journal of oncology, 2000, Volume: 17, Issue:5

    Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents; Breast; Breast Neoplasms; Camptothecin; Cell Cycle; DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Neoplasm Proteins; Protein Kinase C; Staurosporine; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2000
UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:5

    Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA, Neoplasm; Drug Resistance, Neoplasm; G1 Phase; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Pancreatic Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Transplantation, Heterologous

2001