7-hydroxycoumarin and Prostatic-Neoplasms

7-hydroxycoumarin has been researched along with Prostatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 7-hydroxycoumarin and Prostatic-Neoplasms

Article	Year
A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. Bioorganic & medicinal chemistry letters, 2001, Sep-03, Volume: 11, Issue:17 A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements. Topics: 5-alpha Reductase Inhibitors; Coumarins; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Male; Prostatic Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured; Umbelliferones	2001

Article

Year

A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.

Bioorganic & medicinal chemistry letters, 2001, Sep-03, Volume: 11, Issue:17

A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements.

Topics: 5-alpha Reductase Inhibitors; Coumarins; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Male; Prostatic Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured; Umbelliferones

2001