7-hydroxy-2-n,n-dipropylaminotetralin has been researched along with Parkinson Disease in 5 studies
7-hydroxy-2-N,N-dipropylaminotetralin: RN given refers to cpd without isomeric designation
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pramipexole (PPX) is currently being evaluated for treatment of schizophrenia and Parkinson's disease." | 3.69 | Rat brain binding sites for pramipexole, a clinically useful D3-preferring dopamine agonist. ( Camacho-Ochoa, M; Evans, DL; Piercey, MF; Walker, EL, 1995) |
| "The role of iron in the pathogenesis of Parkinson's disease (PD) has been implicated strongly because of generation of oxidative stress leading to dopamine cell death." | 1.36 | Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto ( Antonio, T; Dutta, AK; Ghosh, B; Reith, ME, 2010) |
| "Distinguishing Alzheimer's disease from DLB is clinically relevant in terms of prognosis and appropriate treatment." | 1.30 | Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution. ( Ballard, C; Burn, D; Court, JA; Jaros, E; Johnson, M; Lloyd, S; Marshall, EF; McKeith, IG; Perry, EK; Perry, RH; Piggott, MA; Thomas, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghosh, B | 1 |
| Antonio, T | 1 |
| Reith, ME | 1 |
| Dutta, AK | 1 |
| Camacho-Ochoa, M | 1 |
| Walker, EL | 1 |
| Evans, DL | 1 |
| Piercey, MF | 1 |
| Nagai, Y | 1 |
| Ueno, S | 1 |
| Saeki, Y | 1 |
| Soga, F | 1 |
| Hirano, M | 1 |
| Yanagihara, T | 1 |
| Hurley, MJ | 1 |
| Stubbs, CM | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Piggott, MA | 1 |
| Marshall, EF | 1 |
| Thomas, N | 1 |
| Lloyd, S | 1 |
| Court, JA | 1 |
| Jaros, E | 1 |
| Burn, D | 1 |
| Johnson, M | 1 |
| Perry, RH | 1 |
| McKeith, IG | 1 |
| Ballard, C | 1 |
| Perry, EK | 1 |
5 other studies available for 7-hydroxy-2-n,n-dipropylaminotetralin and Parkinson Disease
| Article | Year |
|---|---|
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto
Topics: Animals; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iron Chelating Agents; | 2010 |
Rat brain binding sites for pramipexole, a clinically useful D3-preferring dopamine agonist.
Topics: Animals; Autoradiography; Benzothiazoles; Binding Sites; Brain; Cloning, Molecular; Dopamine Agonist | 1995 |
Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease.
Topics: Actins; Aged; Base Sequence; Dopamine Agonists; Female; Gene Expression; Humans; Lymphocytes; Male; | 1996 |
D3 receptor expression within the basal ganglia is not affected by Parkinson's disease.
Topics: Aged; Aged, 80 and over; Autoradiography; Basal Ganglia; Dopamine Agonists; Female; Humans; In Situ | 1996 |
Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Corpus Striatum; Dementia; Dopamine; Fe | 1999 |