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7-hydroxy-2-n,n-dipropylaminotetralin and Parkinson Disease

7-hydroxy-2-n,n-dipropylaminotetralin has been researched along with Parkinson Disease in 5 studies

7-hydroxy-2-N,N-dipropylaminotetralin: RN given refers to cpd without isomeric designation

Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Research Excerpts

ExcerptRelevanceReference
"Pramipexole (PPX) is currently being evaluated for treatment of schizophrenia and Parkinson's disease."3.69Rat brain binding sites for pramipexole, a clinically useful D3-preferring dopamine agonist. ( Camacho-Ochoa, M; Evans, DL; Piercey, MF; Walker, EL, 1995)
"The role of iron in the pathogenesis of Parkinson's disease (PD) has been implicated strongly because of generation of oxidative stress leading to dopamine cell death."1.36Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto ( Antonio, T; Dutta, AK; Ghosh, B; Reith, ME, 2010)
"Distinguishing Alzheimer's disease from DLB is clinically relevant in terms of prognosis and appropriate treatment."1.30Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution. ( Ballard, C; Burn, D; Court, JA; Jaros, E; Johnson, M; Lloyd, S; Marshall, EF; McKeith, IG; Perry, EK; Perry, RH; Piggott, MA; Thomas, N, 1999)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ghosh, B1
Antonio, T1
Reith, ME1
Dutta, AK1
Camacho-Ochoa, M1
Walker, EL1
Evans, DL1
Piercey, MF1
Nagai, Y1
Ueno, S1
Saeki, Y1
Soga, F1
Hirano, M1
Yanagihara, T1
Hurley, MJ1
Stubbs, CM1
Jenner, P1
Marsden, CD1
Piggott, MA1
Marshall, EF1
Thomas, N1
Lloyd, S1
Court, JA1
Jaros, E1
Burn, D1
Johnson, M1
Perry, RH1
McKeith, IG1
Ballard, C1
Perry, EK1

Other Studies

5 other studies available for 7-hydroxy-2-n,n-dipropylaminotetralin and Parkinson Disease

ArticleYear
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto
    Journal of medicinal chemistry, 2010, Mar-11, Volume: 53, Issue:5

    Topics: Animals; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iron Chelating Agents;

2010
Rat brain binding sites for pramipexole, a clinically useful D3-preferring dopamine agonist.
    Neuroscience letters, 1995, Aug-18, Volume: 196, Issue:1-2

    Topics: Animals; Autoradiography; Benzothiazoles; Binding Sites; Brain; Cloning, Molecular; Dopamine Agonist

1995
Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease.
    Neurology, 1996, Volume: 46, Issue:3

    Topics: Actins; Aged; Base Sequence; Dopamine Agonists; Female; Gene Expression; Humans; Lymphocytes; Male;

1996
D3 receptor expression within the basal ganglia is not affected by Parkinson's disease.
    Neuroscience letters, 1996, Aug-23, Volume: 214, Issue:2-3

    Topics: Aged; Aged, 80 and over; Autoradiography; Basal Ganglia; Dopamine Agonists; Female; Humans; In Situ

1996
Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution.
    Brain : a journal of neurology, 1999, Volume: 122 ( Pt 8)

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Corpus Striatum; Dementia; Dopamine; Fe

1999