7-hydroxy-2-n,n-dipropylaminotetralin has been researched along with Emesis in 6 studies
7-hydroxy-2-N,N-dipropylaminotetralin: RN given refers to cpd without isomeric designation
| Excerpt | Relevance | Reference |
|---|---|---|
| " In ferrets or dogs, AS-8112 dose-dependently inhibited emesis induced by R(+)-7-OH-DPAT, apomorphine, morphine or cisplatin with ID50 values of 2." | 3.71 | The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist. ( Oka, M; Yoshida, N; Yoshikawa, T, 2001) |
| " Thus, the inhibitory dose-response effects of a D2-preferring [sulpride], a D3-preferring [U 99194A] and combination of varying doses of these antagonists [sulpride + U 99194A] were evaluated on the ability of the cited agonists to produce vomiting." | 1.30 | The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew). ( Ahmad, B; Darmani, NA; Zhao, W, 1999) |
| "0 microgram) administered into the 4th cerebral ventricle dose dependently induced emesis within 1 min of dosing in ferrets." | 1.29 | Involvement of dopamine D3 receptors in the area postrema in R(+)-7-OH-DPAT-induced emesis in the ferret. ( Hosoki, K; Yoshida, N; Yoshikawa, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McDermed, JD | 1 |
| McKenzie, GM | 1 |
| Freeman, HS | 1 |
| Yoshida, N | 4 |
| Yoshikawa, T | 4 |
| Hosoki, K | 2 |
| Darmani, NA | 1 |
| Zhao, W | 1 |
| Ahmad, B | 1 |
| Oka, M | 2 |
6 other studies available for 7-hydroxy-2-n,n-dipropylaminotetralin and Emesis
| Article | Year |
|---|---|
Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene.
Topics: 2-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dogs; Dopamine; Humans; Naphthols; | 1976 |
A dopamine D3 receptor agonist, 7-OH-DPAT, causes vomiting in the dog.
Topics: Animals; Dogs; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Rece | 1995 |
Involvement of dopamine D3 receptors in the area postrema in R(+)-7-OH-DPAT-induced emesis in the ferret.
Topics: Animals; Antiemetics; Cerebral Ventricles; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose | 1996 |
The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew).
Topics: Analysis of Variance; Animals; Apomorphine; Benzopyrans; Brain Chemistry; Disease Models, Animal; Do | 1999 |
The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist.
Topics: Animals; Antiemetics; Antineoplastic Agents; Apomorphine; Azepines; Colon; Dogs; Dopamine Agonists; | 2001 |
Central antiemetic effects of AS-8112, a dopamine D2, D3, and 5-HT(3) receptor antagonist, in ferrets.
Topics: Animals; Antiemetics; Azepines; Cisplatin; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Ferr | 2001 |