7-hydroxy-2-n,n-dipropylaminotetralin has been researched along with Disease Models, Animal in 15 studies
7-hydroxy-2-N,N-dipropylaminotetralin: RN given refers to cpd without isomeric designation
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to examine the effects of preferential agonists of dopamine D3 receptors: pramipexole and 7-OH-DPAT on the harmaline-induced tremor in rats (a model of essential tremor, ET)." | 7.83 | Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats. ( Ananthan, S; Głowacka, U; Kosmowska, B; Ossowska, K; Wardas, J, 2016) |
| "The aim of the study was to examine the effects of preferential agonists of dopamine D3 receptors: pramipexole and 7-OH-DPAT on the harmaline-induced tremor in rats (a model of essential tremor, ET)." | 3.83 | Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats. ( Ananthan, S; Głowacka, U; Kosmowska, B; Ossowska, K; Wardas, J, 2016) |
| " Intranasal drug administration may be useful for Parkinson's treatment because this route avoids first-pass metabolism and increases bioavailability in the brain." | 1.39 | Intranasal and subcutaneous administration of dopamine D3 receptor agonists functionally restores nigrostriatal dopamine in MPTP-treated mice. ( Chen, JC; Hsieh, YT; Kuo, YH; Lao, CL, 2013) |
| "The role of iron in the pathogenesis of Parkinson's disease (PD) has been implicated strongly because of generation of oxidative stress leading to dopamine cell death." | 1.36 | Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto ( Antonio, T; Dutta, AK; Ghosh, B; Reith, ME, 2010) |
| " Thus, the inhibitory dose-response effects of a D2-preferring [sulpride], a D3-preferring [U 99194A] and combination of varying doses of these antagonists [sulpride + U 99194A] were evaluated on the ability of the cited agonists to produce vomiting." | 1.30 | The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew). ( Ahmad, B; Darmani, NA; Zhao, W, 1999) |
| "These findings show that cataplexy may be regulated by D2/D3 dopaminergic receptors in the ventral tegmental area and perhaps the globus pallidus/ putamen." | 1.29 | Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine. ( Mignot, E; Nishino, S; Reid, MS; Sampathkumaran, R; Siegel, JM; Tafti, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ghosh, B | 1 |
| Antonio, T | 1 |
| Reith, ME | 1 |
| Dutta, AK | 2 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lao, CL | 1 |
| Kuo, YH | 1 |
| Hsieh, YT | 1 |
| Chen, JC | 1 |
| Kozyrev, N | 1 |
| Staudt, MD | 1 |
| Brown, A | 1 |
| Coolen, LM | 1 |
| Kosmowska, B | 1 |
| Wardas, J | 1 |
| Głowacka, U | 1 |
| Ananthan, S | 1 |
| Ossowska, K | 1 |
| Lukacova, K | 1 |
| Pavukova, E | 1 |
| Kostal, L | 1 |
| Bilcik, B | 1 |
| Kubikova, L | 1 |
| Yedlapudi, D | 1 |
| Joshi, GS | 1 |
| Luo, D | 1 |
| Todi, SV | 1 |
| Van Kampen, JM | 1 |
| Eckman, CB | 1 |
| Ueda, H | 1 |
| Sato, K | 1 |
| Okumura, F | 1 |
| Misu, Y | 1 |
| Flores, G | 1 |
| Barbeau, D | 1 |
| Quirion, R | 1 |
| Srivastava, LK | 1 |
| Reid, MS | 1 |
| Tafti, M | 1 |
| Nishino, S | 1 |
| Sampathkumaran, R | 1 |
| Siegel, JM | 1 |
| Mignot, E | 1 |
| Darmani, NA | 1 |
| Zhao, W | 1 |
| Ahmad, B | 1 |
| Ellenbroek, BA | 1 |
| van Luijtelaar, G | 1 |
| Frenken, M | 1 |
| Cools, AR | 1 |
| Takamori, K | 1 |
| Yoshida, S | 1 |
| Okuyama, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| a Pilot Study of Pramipexole to Treat Extrapyramidal Symptoms Induced by Antipsychotics[NCT03430596] | Early Phase 1 | 50 participants (Actual) | Interventional | 2018-05-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 other studies available for 7-hydroxy-2-n,n-dipropylaminotetralin and Disease Models, Animal
| Article | Year |
|---|---|
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto
Topics: Animals; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iron Chelating Agents; | 2010 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Intranasal and subcutaneous administration of dopamine D3 receptor agonists functionally restores nigrostriatal dopamine in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Animals; Corpus Striatum; | 2013 |
Chronic Contusion Spinal Cord Injury Impairs Ejaculatory Reflexes in Male Rats: Partial Recovery by Systemic Infusions of Dopamine D3 Receptor Agonist 7OHDPAT.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dopamine Agonists; Ejaculation; Electric Stimulati | 2016 |
Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.
Topics: Amisulpride; Animals; Anti-Dyskinesia Agents; Benzothiazoles; Disease Models, Animal; Dopamine Agoni | 2016 |
Dopamine D3 receptors modulate the rate of neuronal recovery, cell recruitment in Area X, and song tempo after neurotoxic damage in songbirds.
Topics: Animals; Avian Proteins; Cell Movement; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Fi | 2016 |
Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Biological Assay; Circular Dichroism; Disease Models, Anim | 2016 |
Dopamine D3 receptor agonist delivery to a model of Parkinson's disease restores the nigrostriatal pathway and improves locomotor behavior.
Topics: Animals; Cell Division; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Female; Motor Ac | 2006 |
L-DOPA inhibits spontaneous acetylcholine release from the striatum of experimental Parkinson's model rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Agon | 1995 |
Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus.
Topics: Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Benzazepines; Disease Models, Animal; | 1996 |
Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine.
Topics: Amygdala; Animals; Azepines; Cataplexy; Disease Models, Animal; Dogs; Dopamine; Dopamine Agents; Dop | 1996 |
The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew).
Topics: Analysis of Variance; Animals; Apomorphine; Benzopyrans; Brain Chemistry; Disease Models, Animal; Do | 1999 |
Sensory gating in rats: lack of correlation between auditory evoked potential gating and prepulse inhibition.
Topics: Animals; Disease Models, Animal; Dopamine; Dopamine Agonists; Evoked Potentials, Auditory; Inhibitio | 1999 |
Repeated treatment with imipramine, fluvoxamine and tranylcypromine decreases the number of escape failures by activating dopaminergic systems in a rat learned helplessness test.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; Benzazep | 2001 |