7-hydroxy-2-methoxy-1-4-phenanthrenedione has been researched along with Hemolysis* in 1 studies
1 other study(ies) available for 7-hydroxy-2-methoxy-1-4-phenanthrenedione and Hemolysis
| Article | Year |
|---|---|
Phenanthrenes from Arundina graminifolia and in vitro evaluation of their antibacterial and anti-haemolytic properties.
Chemical investigation and activity test of Arundina graminifolia led to the isolation of six phenanthrenes: blestriarene A (1), shancidin (2), densiflorol B (3), ephemeranthoquinone (4), coelonin (5) and lusianthridin (6). The isolated compounds demonstrated antibacterial and anti-haemolytic activities. It was found that compounds 1 and 2 had medium antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli, with MICs of 20-40 μg/mL and MBCs of 40-320 μg/mL. Bactericidal mechanisms were explored. Rupture of cell wall and membrane and leakage of nuclear mass were observed by transmission electron microscopy (TEM). Moreover, compounds 1-3 attenuated the erythrocyte damage. Compounds 1 and 2 showed significant anti-haemolytic activity with inhibition rate about 50% at 16 μg/mL. Topics: Animals; Anti-Bacterial Agents; Bacillus subtilis; Drug Evaluation, Preclinical; Erythrocytes; Escherichia coli; Hemolysis; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Molecular Structure; Orchidaceae; Phenanthrenes; Rabbits; Staphylococcus aureus | 2018 |