7-epiclusianone has been researched along with Schistosomiasis-mansoni* in 1 studies
1 other study(ies) available for 7-epiclusianone and Schistosomiasis-mansoni
| Article | Year |
|---|---|
In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS.
The tetraprenylated benzophenone 7-epiclusianone (7-epi) is a substance isolated from the fruits of Garcinia brasiliensis and in vitro studies have demonstrated that 7-epi is effective against Schistosoma mansoni adult worms.. Here we report the in vivo evaluation of 7-epi and its pharmacokinetic in healthy and Schistosoma mansoni infected mice.. In this work, we assayed the schistosomicidal activity of 7-epi at the dose of 100 mg/kg and 300 mg/kg body weight/day in S. mansoni experimentally infected mice. Besides, two groups of animals were treated and a detailed analysis of plasma samples was performed by liquid chromatography coupled to mass spectrometry (LC-MS/MS).. The results showed significant schistosomicidal in vivo activity at 300 mg/kg. In addition, livers from S. mansoni infected mice showed a greater number of egg granulomas and the changes in the pharmacokinetic parameters in this group could be associated with the pathology of the murine experimental schistosomiasis. Topics: Animals; Benzophenones; Benzoquinones; Chromatography, Liquid; Female; Garcinia; Granuloma; Half-Life; Liver; Mice; Reproducibility of Results; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Tandem Mass Spectrometry | 2018 |