7-deazapurine and Leukemia

7-deazapurine has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for 7-deazapurine and Leukemia

ArticleYear
Substituted purine and 7-deazapurine compounds as modulators of epigenetic enzymes: a patent evaluation (WO2012075381).
    Expert opinion on therapeutic patents, 2013, Volume: 23, Issue:4

    The patent presents 140 purine and 7-azapurine derivatives as potent inhibitors of DOT1L histone methyltransferase that might be useful in the treatment of leukemia with MLL rearrangements. It is becoming more and more evident that the deregulation of chromatin modifiers such as DOT1L plays a critical role in tumorigenesis. As yet, the number of pharmaceutical agents targeting chromatin modifiers is still limited. The market for such compounds has been estimated to be potentially as large as one third of all cancer patients. Overall, the prospective of a targeted product (i.e., a drug targeting a commonly affected chromatin modifier) is very promising, and exponentially growing investments into this market are anticipated.

    Topics: Animals; Antineoplastic Agents; Drug and Narcotic Control; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Methyltransferases; Molecular Structure; Molecular Targeted Therapy; Patents as Topic; Purines; Structure-Activity Relationship

2013