7-deazaadenine and Laryngeal-Neoplasms

7-deazaadenine has been researched along with Laryngeal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 7-deazaadenine and Laryngeal-Neoplasms

Article	Year
(+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- (1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol, the carbocyclic analogue of tubercidin. Journal of medicinal chemistry, 1984, Volume: 27, Issue:4 (+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- 1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol (9), the carbocyclic analogue of tubercidin, prepared from (+/-)-3-amino-5-(hydroxymethyl)-(1 alpha,2 alpha,3 beta,5 beta)- 1,2-cyclopentanediol (6), is cytotoxic to cells containing adenosine kinase but not to cells that do not, indicating that its activity depends on phosphorylation. Although inactive against P388 leukemia in mice and against herpes and influenza viruses in vitro, it showed marginal activity against respiratory syncytial, vesicular stomatitis, and rhino viruses in vitro. Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carcinoma, Squamous Cell; Cell Line; Humans; Indicators and Reagents; Laryngeal Neoplasms; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Ribonucleosides; Structure-Activity Relationship; Tubercidin	1984

Article

Year

(+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- (1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol, the carbocyclic analogue of tubercidin.

Journal of medicinal chemistry, 1984, Volume: 27, Issue:4

(+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- 1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol (9), the carbocyclic analogue of tubercidin, prepared from (+/-)-3-amino-5-(hydroxymethyl)-(1 alpha,2 alpha,3 beta,5 beta)- 1,2-cyclopentanediol (6), is cytotoxic to cells containing adenosine kinase but not to cells that do not, indicating that its activity depends on phosphorylation. Although inactive against P388 leukemia in mice and against herpes and influenza viruses in vitro, it showed marginal activity against respiratory syncytial, vesicular stomatitis, and rhino viruses in vitro.

Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carcinoma, Squamous Cell; Cell Line; Humans; Indicators and Reagents; Laryngeal Neoplasms; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Ribonucleosides; Structure-Activity Relationship; Tubercidin

1984