7-chlorokynurenic acid has been researched along with Seizures in 17 studies
7-chlorokynurenic acid: selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex; structure given in first source
7-chlorokynurenic acid : A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 7.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 7.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "1-10 nmol; direct GABA(A) agonist); (3) YM90K (3-10 mg/kg; AMPA receptor antagonist); and (4) diazepam (2 and 5 mg/kg) and carbamazepine (5 and 20 mg/kg), two standard anticonvulsants, using the partially-kindled hippocampal model for epileptic seizures in freely moving rats." | 3.70 | Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation. ( Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M, 1998) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 3.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 3.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "Furthermore, the seizure threshold of DMCM was increased by intracerebroventricular (i." | 1.30 | Role of the NMDA receptor complex in DMCM-induced seizure in mice. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil." | 1.30 | Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "7CKA did not affect NMDA-induced convulsions but reduced the D-serine potentiation of NMDA responses." | 1.28 | In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site. ( Peeters, BW; Vanderheyden, PM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (88.24) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peterson, SL | 2 |
| Doyle, KM | 1 |
| Shaw, GG | 1 |
| Tsuda, M | 2 |
| Suzuki, T | 2 |
| Misawa, M | 2 |
| Katsumori, H | 1 |
| Minabe, Y | 1 |
| Osawa, M | 1 |
| Ashby, CR | 1 |
| Micheli, F | 1 |
| Cugola, A | 1 |
| Donati, D | 1 |
| Missio, A | 1 |
| Pecunioso, A | 1 |
| Reggiani, A | 2 |
| Tarzia, G | 1 |
| Bonina, FP | 1 |
| Arenare, L | 1 |
| Ippolito, R | 1 |
| Boatto, G | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| de Caprariis, P | 1 |
| Ohtani, K | 1 |
| Tanaka, H | 1 |
| Yoneda, Y | 1 |
| Yasuda, H | 1 |
| Ito, A | 1 |
| Nagata, R | 1 |
| Nakamura, M | 1 |
| Wood, ER | 1 |
| Bussey, TJ | 1 |
| Phillips, AG | 1 |
| Peeters, BW | 1 |
| Vanderheyden, PM | 1 |
| Croucher, MJ | 2 |
| Bradford, HF | 2 |
| Singh, L | 1 |
| Oles, RJ | 1 |
| Tricklebank, MD | 1 |
| Chiamulera, C | 1 |
| Costa, S | 1 |
| Koek, W | 1 |
| Colpaert, FC | 1 |
| Wardas, J | 1 |
| Graham, J | 1 |
| Gale, K | 1 |
17 other studies available for 7-chlorokynurenic acid and Seizures
| Article | Year |
|---|---|
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pent | 1994 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotect | 1996 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid An | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug I | 1997 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Aci | 1998 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino A | 1997 |
Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Esters; Excitatory Amino Acid Agonists; Excitatory Am | 2000 |
In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.
Topics: Aminoquinolines; Animals; Binding, Competitive; Brain; Cells, Cultured; Dizocilpine Maleate; Dose-Re | 2002 |
A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo.
Topics: Animals; Glycine; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Kynurenic A | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rat | 1991 |
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic A | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male | 1990 |
7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizure kindling.
Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Kindling, Neurologic; Kynurenic Acid; Limb | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic A | 1990 |