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7-chlorokynurenic acid and Nerve Degeneration

7-chlorokynurenic acid has been researched along with Nerve Degeneration in 6 studies

7-chlorokynurenic acid: selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex; structure given in first source
7-chlorokynurenic acid : A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
"The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration."7.68The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990)
"The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration."3.68The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990)
" Agonists of the glycine recognition site of NMDA receptors (D-serine and D-alanine) did not have any toxic effect in hippocampal cultures, whereas competitive blockade of the glycine site by 7-chlorokynurenic acid was neuroprotective."1.33Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. ( Barth, A; Barth, L; Newell, DW; Nguyen, LB, 2005)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's3 (50.00)18.2507
2000's2 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barth, A1
Nguyen, LB1
Barth, L1
Newell, DW1
Lee, SC1
Schwarcz, R1
Mosinger, JL1
Price, MT1
Bai, HY1
Xiao, H1
Wozniak, DF1
Olney, JW1
McNamara, D1
Dingledine, R1
Priestley, T1
Horne, AL1
McKernan, RM1
Kemp, JA1
Shalaby, I1
Chenard, B1
Prochniak, M1

Other Studies

6 other studies available for 7-chlorokynurenic acid and Nerve Degeneration

ArticleYear
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
    Experimental brain research, 2005, Volume: 161, Issue:3

    Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistanc

2005
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
    Neuroscience letters, 2001, May-25, Volume: 304, Issue:3

    Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degen

2001
Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina.
    Experimental neurology, 1991, Volume: 113, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Female; Ischemia; Kynurenic Acid; Light; Nerve Degenerati

1991
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:12

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminob

1990
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
    Brain research, 1990, Oct-29, Volume: 531, Issue:1-2

    Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypox

1990
Glycine reverses 7-Cl kynurenate blockade of glutamate neurotoxicity in cell culture.
    European journal of pharmacology, 1989, Jan-31, Volume: 160, Issue:2

    Topics: Animals; Cells, Cultured; Drug Interactions; Glutamates; Glycine; Hippocampus; Kynurenic Acid; L-Lac

1989