7-chlorokynurenic acid has been researched along with Disease Models, Animal in 10 studies
7-chlorokynurenic acid: selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex; structure given in first source
7-chlorokynurenic acid : A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As a first step in the exploration of this approach, we examined the effect of 4-chloro-kynurenine (4-Cl-KYN), which is converted by astrocytes to the potent NMDA glycine-site antagonist 7-chloro-kynurenic acid (7-Cl-KYNA), on the in vivo epileptiform evoked potentials in the CA1 region of rats with chronic limbic epilepsy (CLE)." | 3.73 | In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls. ( Bertram, EH; Schwarcz, R; Williamson, JM; Wu, HQ; Zhang, DX, 2005) |
| "Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM)." | 1.40 | Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage. ( Brown, AM; Chen, S; Evans, RD; Hamner, MA; Ransom, BR; Yang, X; Ye, ZC, 2014) |
| "Neuronal loss and gliosis in these animals were examined immunohistochemically." | 1.33 | Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. ( Bertram, EH; Goodman, JH; Rassoulpour, A; Scharfman, HE; Schwarcz, R; Wu, HQ, 2005) |
| "These results indicate that memory deficits induced by both hypoxia and PTZ involve NMDA receptor activation." | 1.31 | Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning. ( Capdevila, J; Skolnick, P; Trullas, R; Viu, E; Zapata, A, 2000) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil." | 1.30 | Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Yaksh, TL | 1 |
| Schwarcz, R | 3 |
| Snodgrass, HR | 1 |
| Yang, X | 1 |
| Hamner, MA | 1 |
| Brown, AM | 1 |
| Evans, RD | 1 |
| Ye, ZC | 1 |
| Chen, S | 1 |
| Ransom, BR | 1 |
| Liu, BB | 2 |
| Luo, L | 2 |
| Liu, XL | 2 |
| Geng, D | 2 |
| Liu, Q | 2 |
| Yi, LT | 2 |
| Li, CF | 1 |
| Chen, XM | 1 |
| Chen, SM | 1 |
| Mu, RH | 1 |
| Martins, MA | 1 |
| De Castro Bastos, L | 1 |
| Melo, NE | 1 |
| Tonussi, CR | 1 |
| Wu, HQ | 2 |
| Rassoulpour, A | 1 |
| Goodman, JH | 1 |
| Scharfman, HE | 1 |
| Bertram, EH | 2 |
| Zhang, DX | 1 |
| Williamson, JM | 1 |
| Tsuda, M | 1 |
| Suzuki, T | 1 |
| Misawa, M | 1 |
| Viu, E | 1 |
| Zapata, A | 1 |
| Capdevila, J | 1 |
| Skolnick, P | 1 |
| Trullas, R | 1 |
10 other studies available for 7-chlorokynurenic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine | 2017 |
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Di | 2014 |
7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Kynurenic | 2015 |
Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic acid.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease Mode | 2016 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; | 2010 |
Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; E | 2005 |
In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography | 2005 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug I | 1997 |
Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Anta | 2000 |