7-chlorokynurenic acid has been researched along with Brain Disorders in 2 studies
7-chlorokynurenic acid: selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex; structure given in first source
7-chlorokynurenic acid : A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lehmann, JC | 1 |
| Procureur, D | 1 |
| Wood, PL | 1 |
| Wu, HQ | 1 |
| Lee, SC | 1 |
| Schwarcz, R | 1 |
2 other studies available for 7-chlorokynurenic acid and Brain Disorders
| Article | Year |
|---|---|
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetylt | 1993 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Aci | 2000 |