7-chlorokynurenic acid has been researched along with Aura in 5 studies
7-chlorokynurenic acid: selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex; structure given in first source
7-chlorokynurenic acid : A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Excerpt | Relevance | Reference |
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"As a first step in the exploration of this approach, we examined the effect of 4-chloro-kynurenine (4-Cl-KYN), which is converted by astrocytes to the potent NMDA glycine-site antagonist 7-chloro-kynurenic acid (7-Cl-KYNA), on the in vivo epileptiform evoked potentials in the CA1 region of rats with chronic limbic epilepsy (CLE)." | 3.73 | In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls. ( Bertram, EH; Schwarcz, R; Williamson, JM; Wu, HQ; Zhang, DX, 2005) |
"Neuronal loss and gliosis in these animals were examined immunohistochemically." | 1.33 | Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. ( Bertram, EH; Goodman, JH; Rassoulpour, A; Scharfman, HE; Schwarcz, R; Wu, HQ, 2005) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (60.00) | 18.2507 |
2000's | 2 (40.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Wu, HQ | 2 |
Rassoulpour, A | 1 |
Goodman, JH | 1 |
Scharfman, HE | 1 |
Bertram, EH | 2 |
Schwarcz, R | 2 |
Zhang, DX | 1 |
Williamson, JM | 1 |
Rundfeldt, C | 1 |
Wlaź, P | 1 |
Löscher, W | 1 |
Domenici, MR | 1 |
Longo, R | 1 |
Sagratella, S | 1 |
Namba, T | 1 |
Morimoto, K | 1 |
Katayama, K | 1 |
Inoue, K | 1 |
Yamada, N | 1 |
Otsuki, S | 1 |
5 other studies available for 7-chlorokynurenic acid and Aura
Article | Year |
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Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; E | 2005 |
In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography | 2005 |
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling, | 1994 |
7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid.
Topics: Animals; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniqu | 1996 |
Effects of strychnine-insensitive glycine receptor antagonist (7-chlorokynurenic acid) on amygdala kindling in rats.
Topics: Amygdala; Analysis of Variance; Animals; Epilepsy; Kindling, Neurologic; Kynurenic Acid; Male; Rats; | 1992 |