7-chlorokynurenic acid has been researched along with Age-Related Memory Disorders in 2 studies
7-chlorokynurenic acid: selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex; structure given in first source
7-chlorokynurenic acid : A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine plays an important role in modulating acquisition and retention in learning and memory process in experimental animals." | 1.32 | Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats. ( Kamei, C; Nishiga, M, 2003) |
| "These results indicate that memory deficits induced by both hypoxia and PTZ involve NMDA receptor activation." | 1.31 | Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning. ( Capdevila, J; Skolnick, P; Trullas, R; Viu, E; Zapata, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishiga, M | 1 |
| Kamei, C | 1 |
| Viu, E | 1 |
| Zapata, A | 1 |
| Capdevila, J | 1 |
| Skolnick, P | 1 |
| Trullas, R | 1 |
2 other studies available for 7-chlorokynurenic acid and Age-Related Memory Disorders
| Article | Year |
|---|---|
Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats.
Topics: Animals; Excitatory Amino Acid Antagonists; Histamine; Kynurenic Acid; Male; Memory Disorders; Methy | 2003 |
Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Anta | 2000 |