7-8-dihydroxyflavanone and Leukemia

7-8-dihydroxyflavanone has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for 7-8-dihydroxyflavanone and Leukemia

Article	Year
7, 8-dihydroxyflavanone as an inhibitor for Jun-Fos-DNA complex formation and its cytotoxic effect on cultured human cancer cells. Natural product research, 2003, Volume: 17, Issue:6 7,8-Dihydroxyflavanone, isolated from the seeds of Alpinia Katsumadai Hayata, showed an inhibitory effect on Jun-Fos dimer action. 7,8-Dihydroxyflavanone blocked the action of the dimer on a DNA consensus sequence, the AP-1 binding site. We have concluded that the Jun-Fos heterodimer, bound with 7,8-dihydroxyflavanone, cannot bind to the AP-1 site and therefore results in signal interruption. The 7,8-dihydroxyflavanone was also found to have an in vitro cytotoxic effect against A549 (a human lung cancer cell line) and K562 (a human leukemia cell line). Topics: Alpinia; DNA Adducts; Flavanones; Genes, fos; Genes, jun; Leukemia; Lung Neoplasms; Transcription Factor AP-1; Transcription, Genetic; Tumor Cells, Cultured	2003

Article

Year

7, 8-dihydroxyflavanone as an inhibitor for Jun-Fos-DNA complex formation and its cytotoxic effect on cultured human cancer cells.

Natural product research, 2003, Volume: 17, Issue:6

7,8-Dihydroxyflavanone, isolated from the seeds of Alpinia Katsumadai Hayata, showed an inhibitory effect on Jun-Fos dimer action. 7,8-Dihydroxyflavanone blocked the action of the dimer on a DNA consensus sequence, the AP-1 binding site. We have concluded that the Jun-Fos heterodimer, bound with 7,8-dihydroxyflavanone, cannot bind to the AP-1 site and therefore results in signal interruption. The 7,8-dihydroxyflavanone was also found to have an in vitro cytotoxic effect against A549 (a human lung cancer cell line) and K562 (a human leukemia cell line).

Topics: Alpinia; DNA Adducts; Flavanones; Genes, fos; Genes, jun; Leukemia; Lung Neoplasms; Transcription Factor AP-1; Transcription, Genetic; Tumor Cells, Cultured

2003