Compounds > 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Page last updated: 2024-08-23

7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and Cell Transformation, Neoplastic

7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide has been researched along with Cell Transformation, Neoplastic in 64 studies

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-199019 (29.69)18.7374
1990's8 (12.50)18.2507
2000's21 (32.81)29.6817
2010's15 (23.44)24.3611
2020's1 (1.56)2.80

Authors

AuthorsStudies
Chen, K; Chen, X; Jiang, Y; Li, M; Li, W; Ling, Y; Lu, X; Xiao, Z; Xu, M; Yang, Z1
Jiang, Y; Liu, H; Peng, B; Wu, J; Xu, E; Yang, Q; Zhang, S1
Chen, G; Chen, L; Fu, K; Gao, J; Huang, C; Huang, H; Jin, H; Li, J; Li, Y; Liu, P; Liu, Y; Pan, X; Yang, C; Zeng, X; Zhang, L; Zhu, J1
Amin, S; Chen, W; Desai, D; Krzeminski, J; Lin, Y; Padilla, MT; Xu, X1
Greenlee, AR; Jiang, Y; Liu, L; Shen, Y; Tan, A; Yang, Q; Zhou, L1
Jiang, Y; Shen, Y; Tan, A; Zhou, L1
Chu, M; Deng, L; Fu, J; Huang, H; Liu, S; Wang, Y; Xu, L; Zhang, L; Zhang, X; Zhou, Z; Zhu, Y1
Chen, L; Chen, W; Ji, W; Lai, Y; Li, D; Li, W; Lin, Y; Ma, R; Pang, Y; Tang, S; Wang, Q; Wei, Q; Xiao, Y; Yang, P; Zheng, Y; Zhuang, Z1
Fukasawa, K; Igarashi, H; Iwaizumi, M; Nagura, K; Shinmura, K; Sugimura, H; Suzuki, M; Yamada, H1
Chen, X; Duan, H; Fu, J; Greenlee, AR; Jiang, Y; Shen, Y1
Chen, LP; Chen, W; Lai, YD; Li, DC; Li, WX; Lin, YC; Lin, ZN; Ma, RL; Pang, YQ; Tang, SF; Wang, Q; Wei, Q; Xiao, YM; Yang, P1
Greenlee, AR; Jiang, YG; Liu, LH; Shen, YL; Zhou, LL1
Cao, G; Ding, J; Gong, W; Han, T; He, G; Huang, L; Huang, S; Liang, J; Ning, B; Sun, W; Wang, H; Wen, W; Wu, K; Wu, M; Xie, W1
Duan, H; Jiang, Y; Wu, Y; Zhang, H1
Greenlee, AR; Han, Z; Jiang, Y; Liu, L; Zhang, H1
Kumar, S; Mukherjee, JJ1
Cai, S; Du, J; Jiang, J; Liu, L; Liu, Q; Sung, KL; Yan, X; Yang, L; Yang, Y; Yu, S; Zhang, H1
Drouin, R; Lacoste, S; Rochette, PJ1
Fu, J; Huang, H; Wang, Y; Yao, B; Ying, X; Yuan, Z; Zhang, L; Zhao, P; Zhong, W; Zhou, Z1
Amin, S; Blake, DC; Gallagher, CJ; Herzog, CR; Jones, NR; Lazarus, P; Mikse, OR; Sun, YW; Weisz, J1
Greenlee, AR; Han, Z; Jiang, Y; Li, X; Wu, J; Wu, Y; Zhao, Y1
Gocinski, R; Kumar, S; Mukherjee, JJ; Williams, J1
Greenlee, AR; Jiang, Y; Li, Y; Liu, H; Wu, J; Yang, C; Zhao, Y1
Jiang, YG; Li, YQ; Liu, HY; Zhao, Y1
Bai, L; Belinsky, SA; Chen, W; Gott, KM; Leng, S; Lin, Y; Padilla, MT; Scott, BR; Tellez, CS; Wilder, JA; Xu, X1
Chen, J; Chen, X; Jiang, Y1
Feng, SM; Ji, WD; Jiang, YG; Wang, M1
Chen, JK; He, M; Ji, WD; Jiang, YG; Lü, JC; Shi, LY; Wu, ZL; Zeng, BH1
An, S; Chen, J; Chen, X; Liu, L; Zhao, Y1
Burke, TJ; Campian, JL; Clark, DR; Eaton, JW; Gao, X; McGregor, WG; Qian, M1
An, SJ; Chen, JK; Chen, XM; Liu, LL; Zhao, YF1
An, SJ; Chang, W; Chen, HJ; Chen, JK; Chen, XM; Jiang, YG; Wei, QY1
Bin, XN; Chen, XM; Fu, J; Jiang, YG1
Amin, S; Desai, D; Ding, M; Hu, Y; Huang, C; Li, J; Lu, Y; Ouyang, W; Qu, Q; Song, L; Yan, Y; Zhang, D1
Bansal, P; Lazo, JS; Oguri, T; Singh, SV; Srivastava, SK1
Cao, H; Fu, J; Jiang, YG; Shen, YL; Zhou, LL1
Callaham, MF; Huberman, E; Jones, CA1
Kakunaga, T; Lo, K1
Chang, GT; Harvey, RG; Weiss, SB1
Lockhart, ML; Rosenberg, BH1
Cerutti, P; Zimmerman, R1
Connell, JR1
Engelhardt, U; Moeroey, T; Schaefer-Ridder, M1
Jeffrey, AM; Milo, GE; Tejwani, R1
Backer, JM; Boerzig, M; Weinstein, IB1
Bauer, B; Caamano, J; Harris, CC; Iizasa, T; Klein-Szanto, AJ; Lechner, J; Metcalf, R; Momiki, S1
Doehmer, J; Doss, AJ; Fields, WR; Haynes, RL; Li, Y; Morrow, CS; Townsend, AJ1
Anderson, LM; Khan, QA1
Kohler, SK; Louden, C; Maher, VM; McCormick, JJ; Reinhold, DS; Yang, D1
Wong, JL; Yuan, B1
Boyer, JC; Cordeiro-Stone, M; Kaufmann, WK1
Collins, JL; Vanderslice, WE1
Krolewski, B; Little, JB; Reynolds, RJ1
Kurian, P; Milo, GE; Ribovich, ML1
Krolewski, B; Little, JB; Nagasawa, H1
Ernst, SM; Hixson, DC; Nairn, RS; Patskan, G; Pelling, JC; Rhode, SL; Slaga, TJ1
He, MC; Zhang, L1
Shay, JW; Werbin, H1
Fahl, WE; Manoharan, TH; Stevens, CW1
Krolewski, B; Little, JB1
Jeffrey, AM; Kurian, P; Milo, GE1
Kaufmann, WK1
Bell, WN; Grisham, JW; Smith, GJ1
Kumari, HL; Kurian, P; Milo, GE1

Reviews

2 review(s) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and Cell Transformation, Neoplastic

ArticleYear
[Mapping DNA damage to understand somatic mutagenesis].
    Medecine sciences : M/S, 2010, Volume: 26, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Codon; DNA; DNA Damage; DNA Methylation; DNA Repair; Genes, p53; Humans; Liver Neoplasms; Lung Neoplasms; Mutagenesis; Neoplasms, Radiation-Induced; Polymerase Chain Reaction; Skin Neoplasms; Sunlight; Ultraviolet Rays

2010
Cell cycle checkpoints and DNA repair preserve the stability of the human genome.
    Cancer metastasis reviews, 1995, Volume: 14, Issue:1

    Topics: Animals; Ataxia Telangiectasia; Benzopyrenes; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA Repair; Gene Expression Regulation; Genes, p53; Genome, Human; Humans; Neoplasms; Neoplasms, Radiation-Induced; Rats; Replicon; Tumor Suppressor Protein p53

1995

Other Studies

62 other study(ies) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and Cell Transformation, Neoplastic

ArticleYear
The Circ_CARM1 controls cell migration by regulating CTNNBIP1 in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells.
    Toxicology letters, 2021, Sep-15, Volume: 348

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adaptor Proteins, Signal Transducing; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; RNA, Circular

2021
Oncogenic role of long noncoding RNA AF118081 in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells.
    Toxicology letters, 2014, Sep-17, Volume: 229, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Bronchi; Carcinogens; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Gene Knockdown Techniques; Humans; Lung Neoplasms; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Oncogenes; Real-Time Polymerase Chain Reaction; Respiratory Mucosa; RNA Interference; RNA, Long Noncoding

2014
PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Aug-15, Volume: 21, Issue:16

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lung Neoplasms; Mice; MicroRNAs; Phosphoprotein Phosphatases

2015
Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide.
    Molecular carcinogenesis, 2016, Volume: 55, Issue:11

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Cell Line; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Epithelial Cells; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Lung; MAP Kinase Signaling System; Quercetin; Signal Transduction; STAT3 Transcription Factor

2016
Silencing of N-Ras gene expression using shRNA decreases transformation efficiency and tumor growth in transformed cells induced by anti-BPDE.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 105, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Blotting, Western; Carcinogens; Cell Cycle; Cell Line, Transformed; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; RNA, Small Interfering; Transfection; Tumor Stem Cell Assay; Up-Regulation

2008
[Study on expression of Ras family gene in transformed cells induced by BPDE].
    Wei sheng yan jiu = Journal of hygiene research, 2008, Volume: 37, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Genes, ras; Humans; ras Proteins; RNA, Messenger

2008
TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide.
    Toxicology, 2008, Oct-30, Volume: 252, Issue:1-3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Blotting, Western; Bronchi; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Databases, Protein; Electrophoresis, Gel, Two-Dimensional; Epithelial Cells; Gene Expression; Humans; Immunohistochemistry; Immunoprecipitation; Isoelectric Focusing; Microtubule-Associated Proteins; Mutagens; Nuclear Proteins; Phosphorylation; RNA Interference; RNA, Small Interfering; Sister Chromatid Exchange; Tyrosine

2008
Development of human cell models for assessing the carcinogenic potential of chemicals.
    Toxicology and applied pharmacology, 2008, Nov-01, Volume: 232, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Cytochrome P-450 CYP1A1; Genes, myc; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Nickel

2008
Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE).
    The Journal of pathology, 2008, Volume: 216, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Cell Cycle; Cell Transformation, Neoplastic; Centrosome; Chi-Square Distribution; Chromosomal Instability; DNA Adducts; DNA-Directed DNA Polymerase; Female; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Profiling; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lung Neoplasms; Male; Middle Aged; Mutagens; Oligonucleotide Array Sequence Analysis; Tumor Suppressor Protein p53

2008
Effects of silencing of HER2/neu gene in anti-BPDE-transformed cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Cell Cycle; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Epithelial Cells; Genes, erbB-2; Humans; Mutagens; Receptor, ErbB-2; RNA Interference; RNA, Messenger; RNA, Small Interfering; Stem Cells; Transfection

2009
[Establishment and application of oncogene over expressed human epithelial cell transformation model].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2008, Volume: 42, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression; Gene Expression Regulation; Genes, myc; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Mice, Nude

2008
MicroRNA expression profiles and miR-10a target in anti-benzo[a] pyrene-7, 8-diol-9, 10-epoxide-transformed human 16HBE cells.
    Biomedical and environmental sciences : BES, 2009, Volume: 22, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Profiling; Homeodomain Proteins; Humans; MicroRNAs; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors

2009
Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.
    The Journal of biological chemistry, 2009, Nov-27, Volume: 284, Issue:48

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antibiotics, Antineoplastic; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Cyclin D1; Epithelial Cells; Gene Expression; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Nude; Models, Biological; Mutation; Neoplasms, Experimental; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Signal Transduction; Sirolimus

2009
MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene.
    Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Cycle; Cell Separation; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase 6; Environmental Pollutants; Epithelial Cells; Female; Flow Cytometry; Male; Mice; MicroRNAs; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transfection

2010
Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide.
    Life sciences, 2010, Jan-30, Volume: 86, Issue:5-6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Blotting, Western; Carcinogens; Cell Line, Transformed; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation

2010
Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C.
    Mutation research, 2010, Volume: 696, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Down-Regulation; Drug Synergism; Humans; NF-kappa B; Protein Kinase C; Tobacco Smoke Pollution; Transcription Factor AP-1

2010
Targeting eradication of malignant cells derived from human bone marrow mesenchymal stromal cells.
    Experimental cell research, 2010, Dec-10, Volume: 316, Issue:20

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Animals; Antigens, CD; Antimetabolites; Aspartic Acid; Bone Marrow Cells; Cell Differentiation; Cell Survival; Cell Transformation, Neoplastic; Cytosine Deaminase; Escherichia coli Proteins; Flucytosine; Gene Expression; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; Humans; Kruppel-Like Transcription Factors; Lentivirus; Luciferases; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Phosphonoacetic Acid; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Response Elements; Stromal Cells; Telomerase; Transduction, Genetic; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays; Young Adult

2010
Antigen-subtracted 2-DE/MS strategy, a novel proteomic analysis platform.
    Archives of toxicology, 2011, Volume: 85, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antigens; Bronchi; Cell Line, Transformed; Cell Transformation, Neoplastic; Electrophoresis, Gel, Two-Dimensional; Epithelial Cells; Humans; Immunoprecipitation; Mass Spectrometry; Proteomics; Rabbits

2011
FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma.
    Cancer research, 2010, Aug-01, Volume: 70, Issue:15

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Deletion; Genes, Tumor Suppressor; Humans; Lung Neoplasms; RNA, Messenger; Transcriptional Activation

2010
miR-106a-mediated malignant transformation of cells induced by anti-benzo[a]pyrene-trans-7,8-diol-9,10-epoxide.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 119, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Flow Cytometry; Humans; Mice; Mice, Nude; MicroRNAs; Neoplasm Transplantation; Neoplasms, Experimental; Oligonucleotides, Antisense; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Up-Regulation

2011
Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response.
    Chemical research in toxicology, 2011, May-16, Volume: 24, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Carcinogens; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Humans; Mice; NF-kappa B; Nicotiana; Phenols; Smoke; Tumor Suppressor Protein p53

2011
The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide.
    Toxicology letters, 2011, Sep-10, Volume: 205, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Bronchi; Carcinogens; Cell Adhesion; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Mice; Mice, Nude; MicroRNAs; Neoplasm Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Respiratory Mucosa; Resting Phase, Cell Cycle; Tumor Burden; Xenograft Model Antitumor Assays

2011
[Effect of miR-542-3p on carcinogenesis induced by anti-benzo(a) pyrene-7,8-diol-9,10-epoxide].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2011, Volume: 45, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Cell Transformation, Neoplastic; Epithelial Cells; Humans; MicroRNAs; Transfection

2011
Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen.
    Carcinogenesis, 2012, Volume: 33, Issue:7

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Carcinogens; Cell Transformation, Neoplastic; Dose-Response Relationship, Radiation; Epithelial Cells; Fibroblasts; Gamma Rays; Humans; Interleukin-6; Lung; MAP Kinase Signaling System; NF-kappa B; Nicotiana; Smoke

2012
[Malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
    Wei sheng yan jiu = Journal of hygiene research, 2001, Volume: 30, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Humans

2001
[Antitransforming activity of chlorophyllin against trans-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2003, Volume: 37, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Chlorophyllides; Mice; Mice, Inbred BALB C; Neoplasms, Experimental

2003
[Study on lung carcinogenesis associated genes in human lung squamous cell carcinoma and malignant transformation of human bronchial epithelial cells induced by carcinogen].
    Zhonghua yi xue za zhi, 2003, Dec-25, Volume: 83, Issue:24

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Lung Neoplasms; Nickel; Oligonucleotide Array Sequence Analysis

2003
[Gene expression differences between the anti-BPDE-transformed and normal cells by suppression subtractive hybridization].
    Wei sheng yan jiu = Journal of hygiene research, 2004, Volume: 33, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Nucleic Acid Hybridization; Polymerase Chain Reaction

2004
Cytotoxic and mutagenic effects of tobacco-borne free fatty acids.
    Free radical biology & medicine, 2006, Jan-01, Volume: 40, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Adhesion; Cell Transformation, Neoplastic; Cells, Cultured; Fatty Acids, Nonesterified; Fibroblasts; Humans; Hypoxanthine Phosphoribosyltransferase; Iron; Lung; Mice; Mutagens; Mutation; Nicotiana; NIH 3T3 Cells; Phenotype

2006
Over-expressed genes detected by suppression subtractive hybridization in carcinoma derived from transformed 16HBE cells induced by BPDE.
    Biomedical and environmental sciences : BES, 2005, Volume: 18, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens; Carcinoma; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Nucleic Acid Hybridization; Polymerase Chain Reaction; RNA, Messenger

2005
Characterization of 67 kD laminin receptor, a protein whose gene is overexpressed on treatment of cells with anti-benzo[a]pyrene-7,8-diol-9,10-epoxide.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Sequence; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Molecular Sequence Data; Receptors, Laminin; RNA; Sequence Analysis, RNA; Transfection

2006
[Study on E-cadherin, Cyclin D1 and Cyclin E expression in anti-malignant transformation by chlorophyllin].
    Wei sheng yan jiu = Journal of hygiene research, 2006, Volume: 35, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antimutagenic Agents; Cadherins; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chlorophyllides; Cyclin D1; Cyclin E; Epithelial Cells; Humans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2006
Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells.
    Carcinogenesis, 2007, Volume: 28, Issue:10

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Epidermis; Female; Genes, Reporter; Genetic Vectors; Mice; Mice, Nude; NFATC Transcription Factors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tumor Necrosis Factor-alpha

2007
Cell division cycle 25B phosphatase is essential for benzo(a)pyrene-7,8-Diol-9,10-epoxide induced neoplastic transformation.
    Cancer research, 2007, Oct-01, Volume: 67, Issue:19

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Carcinogens; cdc25 Phosphatases; Cell Cycle Proteins; Cell Transformation, Neoplastic; Checkpoint Kinase 1; DNA Damage; Enzyme Induction; Female; Fibroblasts; Humans; Lung; Male; Mice; Mice, Inbred A; Mice, Nude; Protein Kinases

2007
[MicroRNA profiles of malignantly transformed cells induced by anti-benzo-a-pyrene-trans-7, 8-dihydrodiol-9, 10-epoxide].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2008, Volume: 26, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Gene Expression Profiling; Humans; MicroRNAs

2008
Enhancement of chemical-carcinogen-induced cell transformation in hamster embryo cells by 1 alpha,25-dihydroxycholecalciferol, the biologically active metabolite of vitamin D3.
    Carcinogenesis, 1984, Volume: 5, Issue:9

    Topics: 24,25-Dihydroxyvitamin D 3; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Calcitriol; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cholecalciferol; Cricetinae; Dihydroxycholecalciferols; Embryo, Mammalian; Female; Mesocricetus; Methylnitronitrosoguanidine; Pregnancy

1984
Only one type of benzo(a) pyrene-DNA adduct is detected in transformable mouse cells.
    Biochemical and biophysical research communications, 1981, Apr-15, Volume: 99, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Repair; Humans

1981
The fate of SV40 DNA in infected cells after treatment with benzo(a)pyrene diol epoxide.
    Biochemical and biophysical research communications, 1981, Jun-16, Volume: 100, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; DNA Replication; DNA, Viral; Kidney; Male; Mutagens; Simian virus 40; Thymidine; Virus Replication

1981
Inhibition of DNA synthesis, independent of DNA adduct formation, by benzo[a]pyrene diol epoxide in mammalian cells.
    Carcinogenesis, 1983, Volume: 4, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; DNA; DNA Replication; DNA, Viral; Kidney; Kinetics; Simian virus 40; Virus Replication

1983
Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:7

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Gamma Rays; Mice; Mice, Inbred C3H; Oxygen; Tetradecanoylphorbol Acetate; Xanthine; Xanthine Oxidase; Xanthines

1984
Karyotype analysis of carcinogen-treated Chinese hamster cells in vitro evolving from a normal to a malignant phenotype.
    British journal of cancer, 1984, Volume: 50, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Agar; Animals; Benzopyrenes; Carcinogens; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; Fetus; Karyotyping; Lung; Sarcoma, Experimental

1984
Inactivation of the thymidine kinase gene after in vitro modification with benzo(a)pyrene-diol-epoxide and transfer to LTK- cells as a eukaryotic test for carcinogens.
    Cancer research, 1984, Volume: 44, Issue:12 Pt 1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; DNA, Recombinant; Genes; L Cells; Mice; Nucleic Acid Hybridization; Plasmids; Thymidine Kinase

1984
Benzo[a]pyrene diol epoxide DNA adduct formation in transformable and non-transformable human foreskin fibroblast cells in vitro.
    Carcinogenesis, 1982, Volume: 3, Issue:7

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Fibroblasts; Humans; Infant, Newborn; Male; Skin

1982
When do carcinogen-treated 10T1/2 cells acquire the commitment to form transformed foci?
    Nature, 1982, Sep-30, Volume: 299, Issue:5882

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Drug Resistance; Mice; Ouabain; Time Factors

1982
Invasive tumors derived from xenotransplanted, immortalized human cells after in vivo exposure to chemical carcinogens.
    Carcinogenesis, 1993, Volume: 14, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Animals; Bronchi; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epithelium; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Pyrenes; Rats; Rats, Inbred F344; Tracheal Neoplasms; Transplantation, Heterologous

1993
Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection.
    Chemico-biological interactions, 1998, Apr-24, Volume: 111-112

    Topics: 4-Nitroquinoline-1-oxide; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylation; Animals; Cell Line; Cell Transformation, Neoplastic; DNA Damage; Gene Expression; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Inactivation, Metabolic; Isoenzymes; Mice; Neoplasms; Rats; Transfection

1998
Hydrocarbon carcinogens evade cellular defense mechanism of G1 arrest in nontransformed and malignant lung cell lines.
    Toxicology and applied pharmacology, 2001, Jun-01, Volume: 173, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Antineoplastic Agents; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chrysenes; Dactinomycin; DNA Damage; Epithelial Cells; Flow Cytometry; G1 Phase; Genes, p53; Humans; Lung; Lung Neoplasms; Mice; Mutagens; Mutation; Nocodazole; Nucleic Acid Synthesis Inhibitors; Tumor Cells, Cultured

2001
Malignant transformation of human fibroblast cell strain MSU-1.1 by (+-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo [a]pyrene.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Mar-15, Volume: 89, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Calcium; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Banding; Fibroblasts; Growth Substances; Humans

1992
Inactivity of acrylonitrile epoxide to modify a Ha-ras DNA in a non-focus transfection-transformation assay.
    Carcinogenesis, 1991, Volume: 12, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Blotting, Southern; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA; Ethylene Oxide; Genes, ras; Humans; Methylnitrosourea; Plasmids; Proto-Oncogene Mas; Transfection; Transformation, Genetic

1991
Role of postreplication repair in transformation of human fibroblasts to anchorage independence.
    Cancer research, 1991, Jun-01, Volume: 51, Issue:11

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Cell Adhesion; Cell Transformation, Neoplastic; DNA Repair; DNA Replication; Humans; Xeroderma Pigmentosum

1991
Anti-tumor surveillance of non-contact-inhibited transformed cell lines.
    International journal of cancer, 1988, Sep-15, Volume: 42, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antigens, Neoplasm; Azacitidine; Cell Line, Transformed; Cell Transformation, Neoplastic; Histocompatibility Antigens; Immunity, Cellular; Immunologic Surveillance; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Phenotype

1988
Effect of duration of exposure to benzo(a)pyrene diol-epoxide on neoplastic transformation, mutagenesis, cytotoxicity, and total covalent binding to DNA of rodent cells.
    Teratogenesis, carcinogenesis, and mutagenesis, 1988, Volume: 8, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Kinetics; Mice; Mice, Inbred C3H; Mutagens; Mutation; Time Factors

1988
Specific BPDE I modification of replicating and parental DNA from early S phase human foreskin fibroblasts.
    Carcinogenesis, 1986, Volume: 7, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA Adducts; DNA Replication; Fibroblasts; Humans; Interphase; Male; Methylation; Nucleotides

1986
Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene.
    Carcinogenesis, 1986, Volume: 7, Issue:10

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; DNA Damage; Mutation; Pyrenes; Sister Chromatid Exchange

1986
Altered expression of oncogenes in mouse epidermis following exposure to benzo(a)pyrene diol epoxides.
    Advances in experimental medicine and biology, 1986, Volume: 197

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Transformation, Neoplastic; Dihydroxydihydrobenzopyrenes; DNA, Neoplasm; Female; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Oncogenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate

1986
[In vitro studies on the cocarcinogenic activity of CSC-NF to the tracheal epithelium of hamsters].
    Zhonghua yi xue za zhi, 1987, Volume: 67, Issue:4

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Cricetinae; Epithelium; Mesocricetus; Organ Culture Techniques; Smoking; Trachea

1987
Cytoplasmic suppression of tumorigenicity in reconstructed mouse cells.
    Cancer research, 1988, Feb-15, Volume: 48, Issue:4

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Culture Techniques; Dihydroxydihydrobenzopyrenes; Hybrid Cells; Mice

1988
Characterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: sequence analysis of an enzymatically amplified mutant HRAS allele.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:11

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Sequence; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Neoplasm; Genes, ras; Humans; Mice; Molecular Sequence Data; Mutagens

1988
Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives.
    Carcinogenesis, 1985, Volume: 6, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Dihydroxydihydrobenzopyrenes; Mice; Mice, Inbred C3H

1985
Preferential binding of benzo[a]pyrene diol epoxide to the linker DNA of human foreskin fibroblasts in S phase in the presence of benzamide.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzamides; Benzopyrenes; Binding Sites; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Fibroblasts; Humans; Interphase; Skin

1985
Clonal analysis of the expression of multiple transformation phenotypes and tumorigenicity by morphologically transformed 10T1/2 cells.
    Cancer research, 1993, Feb-01, Volume: 53, Issue:3

    Topics: Animals; Bayes Theorem; Benzopyrenes; Cell Division; Cell Separation; Cell Transformation, Neoplastic; Clone Cells; DNA, Neoplasm; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H; Mice, Nude; Phenotype

1993
Selective inhibition of the BPDE-I-induced modification of the replicating DNA of S-phase cells, by benzamide and 3-aminobenzamide.
    Carcinogenesis, 1992, Volume: 13, Issue:3

    Topics: Benzamides; Benzopyrenes; Cell Transformation, Neoplastic; DNA; Fibroblasts; Humans; S Phase

1992