7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide has been researched along with Cancer of Lung in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.53) | 18.7374 |
| 1990's | 19 (24.05) | 18.2507 |
| 2000's | 41 (51.90) | 29.6817 |
| 2010's | 14 (17.72) | 24.3611 |
| 2020's | 3 (3.80) | 2.80 |
| Authors | Studies |
|---|---|
| Abo-Elfadl, MT; Abo-Zeid, MAM; Mahdy-Abdallah, H; Mohammed, AMF; Moubarz, G; Saad-Hussein, A; Saleh, IA; Shahy, EM | 1 |
| Bai, Y; Feng, Y; Fu, M; Guan, X; Guo, H; He, M; Jie, J; Li, G; Li, H; Li, M; Li, Y; Meng, H; Wang, C; Wei, S; Wei, W; Wu, X; Zhang, X | 1 |
| Chen, K; Chen, X; Jiang, Y; Li, M; Li, W; Ling, Y; Lu, X; Xiao, Z; Xu, M; Yang, Z | 1 |
| Cai, Y; Cui, S; Jin, C; Lu, X; Wu, S; Xiao, M; Xue, P; Yang, J; Yu, T; Zhang, G; Zhang, L; Zhang, Q; Zheng, X | 1 |
| Bausinger, J; Duong, G; Linsenmeyer, R; Speit, G | 1 |
| Jiang, Y; Liu, H; Peng, B; Wu, J; Xu, E; Yang, Q; Zhang, S | 1 |
| Dai, J; Hu, G; Jiang, Y; Lai, Y; Nan, A; Yang, C; Yang, T; Zhang, Y; Zheng, J | 1 |
| Chen, G; Chen, L; Fu, K; Gao, J; Huang, C; Huang, H; Jin, H; Li, J; Li, Y; Liu, P; Liu, Y; Pan, X; Yang, C; Zeng, X; Zhang, L; Zhu, J | 1 |
| Brancale, A; Lewis, PD; Menzies, GE; Reed, SH | 1 |
| Chen, C; Jin, Y; Liu, X; Sun, X; Tan, C; Xu, P; Xu, Y; Zhang, C | 1 |
| Bains, M; Begg, CB; Berwick, M; Clas, BA; Dominguez, G; Downey, R; Flores, R; Jani, J; Kris, MG; Mujumdar, U; Orlow, I; Park, BJ; Patel, H; Rizk, N; Rusch, VW; Siu-Lau, P | 1 |
| Fukasawa, K; Igarashi, H; Iwaizumi, M; Nagura, K; Shinmura, K; Sugimura, H; Suzuki, M; Yamada, H | 1 |
| Chen, LC; Gordon, T; Mehta, M; Rom, W; Tang, MS | 1 |
| Dumstorf, CA; Haribabu, B; Krishnan, E; McGregor, WG; Mukhopadhyay, S | 1 |
| Chiang, HC; Tsou, TC | 1 |
| Greenlee, AR; Han, Z; Jiang, Y; Liu, L; Zhang, H | 1 |
| Drouin, R; Lacoste, S; Rochette, PJ | 1 |
| Adams, LD; George, MH; King, LC; Moore, T; Nelson, G; Nesnow, S; Padgett, WT; Ross, JA | 1 |
| Amin, S; Blake, DC; Gallagher, CJ; Herzog, CR; Jones, NR; Lazarus, P; Mikse, OR; Sun, YW; Weisz, J | 1 |
| Greenlee, AR; Jiang, Y; Li, Y; Liu, H; Wu, J; Yang, C; Zhao, Y | 1 |
| Abedin, Z; Field, J; Sen, S | 1 |
| Chen, CM; Jin, YT; Sun, XY; Tan, C; Xu, HY; Zhang, CY; Zhang, H; Zhang, WM | 1 |
| Airoldi, L; Cerri, A; Consonni, E; Mezzetti, M; Pastorelli, R | 1 |
| Makan, N; Spitz, MR; Wu, X; Yu, H | 1 |
| Minna, JD; Schabath, MB; Spitz, MR; Tomlinson, GE; Wu, X; Zhang, H | 1 |
| Lazo, JS; Nemoto, K; Oguri, T; Singh, SV | 1 |
| Kawabe, A; Liang, Z; Lippman, SM; Shimada, Y; Xu, XC | 1 |
| Cheng, L; Spitz, MR; Wang, LE; Wei, Q | 1 |
| Chen, JK; He, M; Ji, WD; Jiang, YG; Lü, JC; Shi, LY; Wu, ZL; Zeng, BH | 1 |
| Chang, JT; Ko, JL; Liao, SH; Lin, P; Lo, WS | 1 |
| Alexandrov, K; Cascorbi, I; Grosdidier, G; Marie, B; Martinet, N; Rojas, M; Siat, J; Vignaud, JM | 1 |
| Kisselev, P; Roots, I; Schwarz, D | 1 |
| Chiang, S; Luo, S; Roth, JA; Spitz, MR; Wu, X; Zhao, H; Zheng, YL | 1 |
| Chen, CY; Hsu, CP; Ko, JL; Lai, JC; Lai, WW; Lee, H; Lin, TS; Weng, MW; Yu, KY | 1 |
| Cheng, YW; Chiou, HL; Hsiao, YM; Hsieh, YS; Ko, JL; Weng, MW; Yang, CH; Yang, SF | 1 |
| Becker, F; Bergan, RC; Bhagat, R; Carmella, SG; Crowell, JA; Folz, RJ; Gallot, L; Glaser, EM; Hecht, SS; Herndon, JE; Kelley, MJ; Perloff, M; Santella, RM; Schilder, L; Zhang, YJ | 1 |
| Du, CH; Xu, J; Zhong, NS | 1 |
| Duan, YY; Long, ZY; Niu, PY; Wu, TC | 1 |
| Cox, LA; Sanders, E | 1 |
| Amos, CI; Dong, Q; Etzel, CJ; Gorlova, OY; Lin, J; Spitz, MR; Wu, X; Zhang, Q | 1 |
| Guo, Z; Qiao, Y; Shi, Q; Spitz, MR; Wang, L; Wei, Q | 1 |
| Carrie, D; Farmer, PB; Gaskell, M; Henderson, CJ; Park, K; Ritchie, KJ; Vassieva, O; Wang, XJ; Wolf, CR | 1 |
| Hahm, ER; Rawal, M; Singh, SV; Xiao, H | 1 |
| Egly, JM; Geacintov, N; Mocquet, V | 1 |
| Castrén, K; Järvinen, K; Pääkkö, P; Pekkala, K; Rämet, M; Soini, Y; Turpeenniemi-Hujanen, T; Vähäkangas, K | 1 |
| Lee, X; Lewtas, J; Mumford, JL; Santella, RM; Young, TL | 1 |
| Cheng, L; Hittelman, WN; Li, D; Spitz, MR; Wang, M; Wei, Q | 1 |
| Bondy, ML; Cheng, L; Gu, J; Hong, WK; Jiang, H; Spitz, MR; Wei, Q | 1 |
| Cheng, L; Hong, WK; Spitz, MR; Wei, Q | 1 |
| Denissenko, MF; Pao, A; Pfeifer, GP; Tang, M | 1 |
| Hu, X; Singh, SV | 1 |
| Choi, KS; Inoue, S; Shinozaki, R | 1 |
| Hong, WK; Honn, SE; Minna, JD; Spitz, MR; Tomlinson, GE; Wu, X; Zhao, Y | 1 |
| Cooper, DN; Krawczak, M | 1 |
| Amos, CI; Gu, J; Hong, WK; Jiang, H; Spitz, MR; Wu, X | 1 |
| Alexandrov, K; Bartsch, H; Risch, A; Rojas, M | 1 |
| Amos, CI; Spitz, MR; Xu, W | 1 |
| Alexandrov, K; Bartsch, H; Nair, J; Nair, U; Rojas, M | 1 |
| Alexandrov, K; Auburtin, G; Bartsch, H; Cascorbi, I; Kopp-Schneider, A; Kriek, E; Mayer, L; Rojas, M; Roots, I | 1 |
| Amos, CI; Hong, WK; Spitz, MR; Wu, X; Yu, H | 2 |
| Hecht, SS; Kenney, PM; Liang, H; Staretz, ME; Sticha, KR; Wang, M | 1 |
| Rodin, AS; Rodin, SN | 1 |
| Jenq, SN; Kang, ZC; Lee, H; Yang, SC | 1 |
| Booth, E; Carnelley, T; Le, XC; Lee, J; Watson, WP; Weinfeld, M; Xing, JZ | 1 |
| Bosken, CH; Firozi, PF; Hong, WK; Li, D; Spitz, MR; Wang, LE; Wei, Q | 1 |
| Patterson, M | 1 |
| Anderson, LM; Khan, QA | 1 |
| Chen, CP; Chen, CY; Cheng, YW; Hsieh, LL; Lee, H; Lin, PP; Lin, TS; Su, JM | 1 |
| Amstad, P; Harris, CC; Haugen, A; Hewer, A; Hofseth, L; Hussain, SP; Phillips, DH; Raja, K; Ryberg, D; Sawyer, M; Shields, PG | 1 |
| Feng, Z; Lee, CS; Pfeifer, GP; Smith, LE; Tang, M; Yoon, JH | 1 |
| Alexandrov, K; Bartsch, H; Camus, AM; Castegnaro, M; Geneste, O; Giuntini, C; Petruzzelli, S; Rojas, M | 1 |
| den Engelse, L; Hillebrand, MJ; Jansen, HM; Kriek, E; van Leeuwen, FE; van Schooten, FJ; van Zandwijk, N | 1 |
| Hillebrand, MJ; Jansen, HM; Kriek, E; Lutgerink, JT; van Leeuwen, FE; van Schooten, FJ; van Zandwijk, N | 1 |
| Harris, CC; Mann, DL; Newman, MJ; Shamsuddin, A; Sinopoli, N; Trivers, GE; Vahakangas, K; Wright, WE | 1 |
| Chang, RL; Conney, AH; Huang, MT; Jerina, DM; Newmark, HL; Sayer, JM; Wong, CQ; Wood, AW; Yagi, H | 1 |
| Alexandrov, K; Bartsch, H; Hillebrand, M; Kriek, E; Rojas, M; van Schooten, FJ | 1 |
| Airoldi, L; Cappelli, R; Cerri, A; Fanelli, R; Fumagalli, F; Guanci, M; La Vecchia, C; Mezzetti, M; Negri, E; Panigalli, T; Pastorelli, R | 1 |
| Barker, S; Carnelley, TJ; Le, XC; Tan, WG; Wang, H; Weinfeld, M | 1 |
4 review(s) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and Cancer of Lung
| Article | Year |
|---|---|
Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; ATP-Binding Cassette Transporters; Benzo(a)pyrene; DNA Adducts; DNA Methylation; Epigenome; Humans; Lung Neoplasms; Ubiquitin-Conjugating Enzymes | 2021 |
[Mapping DNA damage to understand somatic mutagenesis].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Codon; DNA; DNA Damage; DNA Methylation; DNA Repair; Genes, p53; Humans; Liver Neoplasms; Lung Neoplasms; Mutagenesis; Neoplasms, Radiation-Induced; Polymerase Chain Reaction; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2010 |
p53 mutations, benzo[a]pyrene and lung cancer.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Genes, p53; Humans; Lung Neoplasms; Mutation; Selection Bias; Smoking | 1998 |
Is there a genetic basis for lung cancer susceptibility?
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bleomycin; DNA Adducts; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Molecular Epidemiology; Risk Factors | 1999 |
2 trial(s) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and Cancer of Lung
| Article | Year |
|---|---|
Safety and efficacy of weekly oral oltipraz in chronic smokers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Oral; Adult; Aged; Anticarcinogenic Agents; Bronchoalveolar Lavage Fluid; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Polycyclic Aromatic Hydrocarbons; Pyrazines; Smoking; Thiones; Thiophenes | 2005 |
Impact of inherited polymorphisms in glutathione S-transferase M1, microsomal epoxide hydrolase, cytochrome P450 enzymes on DNA, and blood protein adducts of benzo(a)pyrene-diolepoxide.
Topics: Aged; Base Sequence; Benzopyrenes; Biomarkers, Tumor; Blood Proteins; Cytochrome P-450 Enzyme System; DNA, Neoplasm; Epoxide Hydrolases; Genotype; Glutathione Transferase; Humans; Lung Neoplasms; Male; Microsomes, Liver; Middle Aged; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Genetic; Sensitivity and Specificity | 1998 |
73 other study(ies) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and Cancer of Lung
| Article | Year |
|---|---|
Lung cancer risk in workers occupationally exposed to polycyclic aromatic hydrocarbons with emphasis on the role of DNA repair gene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Albumins; Aluminum; Biomarkers, Tumor; DNA Adducts; DNA Repair; Humans; Lung Neoplasms; Occupational Exposure; Polycyclic Aromatic Hydrocarbons | 2023 |
The Circ_CARM1 controls cell migration by regulating CTNNBIP1 in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adaptor Proteins, Signal Transducing; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; RNA, Circular | 2021 |
Rs3212986 polymorphism, a possible biomarker to predict smoking-related lung cancer, alters DNA repair capacity via regulating ERCC1 expression.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Aged, 80 and over; Biomarkers; Carcinogens; Cell Line; DNA Repair; DNA-Binding Proteins; Endonucleases; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Smoking | 2018 |
Investigations on potential co-mutagenic effects of formaldehyde.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylating Agents; Chromosome Aberrations; Comet Assay; Disinfectants; Drug Combinations; Drug Synergism; Formaldehyde; Gamma Rays; Humans; Lung Neoplasms; Methyl Methanesulfonate; Methylnitrosourea; Micronucleus Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2014 |
Oncogenic role of long noncoding RNA AF118081 in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Bronchi; Carcinogens; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Gene Knockdown Techniques; Humans; Lung Neoplasms; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Oncogenes; Real-Time Polymerase Chain Reaction; Respiratory Mucosa; RNA Interference; RNA, Long Noncoding | 2014 |
Functional role and mechanism of lncRNA LOC728228 in malignant 16HBE cells transformed by anti-benzopyrene-trans-7,8-dihydrodiol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Line, Transformed; Humans; Lung Neoplasms; Mice; Mice, Nude; Polymerase Chain Reaction; RNA, Long Noncoding | 2015 |
PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lung Neoplasms; Mice; MicroRNAs; Phosphoprotein Phosphatases | 2015 |
Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Carcinogens; Codon; DNA; DNA Adducts; DNA Damage; Genes, p53; Humans; Hydrogen Bonding; Lung Neoplasms; Molecular Dynamics Simulation; Mutation; Smoking | 2015 |
Cigarette Smoking, BPDE-DNA Adducts, and Aberrant Promoter Methylations of Tumor Suppressor Genes (TSGs) in NSCLC from Chinese Population.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Asian People; Carcinoma, Non-Small-Cell Lung; DNA Adducts; DNA Methylation; Female; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Male; Middle Aged; Promoter Regions, Genetic; Smoking | 2016 |
DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Carcinogens; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Comet Assay; DNA Adducts; DNA Damage; DNA Repair; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms, Multiple Primary | 2008 |
Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE).
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Cell Cycle; Cell Transformation, Neoplastic; Centrosome; Chi-Square Distribution; Chromosomal Instability; DNA Adducts; DNA-Directed DNA Polymerase; Female; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Profiling; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lung Neoplasms; Male; Middle Aged; Mutagens; Oligonucleotide Array Sequence Analysis; Tumor Suppressor Protein p53 | 2008 |
Particulate matter inhibits DNA repair and enhances mutagenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Air Pollutants; Cell Line, Tumor; DNA Repair; DNA Replication; Humans; Lung Neoplasms; Mutagenesis; Particulate Matter; Ultraviolet Rays | 2008 |
REV1 is implicated in the development of carcinogen-induced lung cancer.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Carcinogens; DNA-Directed DNA Polymerase; Fibroblasts; Lung Neoplasms; Male; Mice; Mutagenesis; Nucleotidyltransferases; RNA, Catalytic; RNA, Messenger | 2009 |
Arsenite enhances the benzo[a]pyrene diol epoxide (BPDE)-induced mutagenesis with no marked effect on repair of BPDE-DNA adducts in human lung cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Arsenites; Cell Line; Cell Line, Tumor; DNA Adducts; Drug Synergism; Genes, Suppressor; Humans; Lung; Lung Neoplasms; Mutagenesis; Mutagens; Mutation; RNA, Transfer; Sodium Compounds; Tumor Suppressor Protein p53 | 2009 |
Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Blotting, Western; Carcinogens; Cell Line, Transformed; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2010 |
Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetylcysteine; Animals; Benzo(a)pyrene; Carcinogens; DNA Adducts; Free Radical Scavengers; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Models, Biological; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons | 2010 |
FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Deletion; Genes, Tumor Suppressor; Humans; Lung Neoplasms; RNA, Messenger; Transcriptional Activation | 2010 |
The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Bronchi; Carcinogens; Cell Adhesion; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Mice; Mice, Nude; MicroRNAs; Neoplasm Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Respiratory Mucosa; Resting Phase, Cell Cycle; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma of Lung; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Benzo(a)pyrene; Cell Line, Tumor; Dihydroxydihydrobenzopyrenes; Epithelial Cells; Heme Oxygenase-1; Humans; Lung Neoplasms; Quinones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
[Effects of CYP1A1 and GSTM1 gene polymorphisms and BPDE-DNA adducts on lung cancer].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens; Case-Control Studies; Cytochrome P-450 CYP1A1; DNA Adducts; Female; Genotype; Glutathione Transferase; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic | 2012 |
Effect of DNA repair gene polymorphisms on BPDE-DNA adducts in human lymphocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; DNA Adducts; DNA Damage; DNA Helicases; DNA Repair; DNA-Binding Proteins; Gas Chromatography-Mass Spectrometry; Genotype; Humans; Lung Neoplasms; Lymphocytes; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proteins; Smoking; Transcription Factors; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein | 2002 |
Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bleomycin; Chromatids; Chromosome Aberrations; Enzyme-Linked Immunosorbent Assay; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Lung Neoplasms; Lymphocytes; Mutagenicity Tests; Mutagens; Predictive Value of Tests; Risk Factors | 2003 |
Modification of lung cancer susceptibility by green tea extract as measured by the comet assay.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Biomarkers, Tumor; Carcinogens; Case-Control Studies; Comet Assay; Disease Susceptibility; DNA; DNA Damage; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Lymphocytes; Plant Extracts; Tea; Tumor Cells, Cultured | 2002 |
The carcinogen (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces Cdc25B expression in human bronchial and lung cancer cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma, Bronchiolo-Alveolar; Bronchi; Carcinogens; Carcinoma, Squamous Cell; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Epithelial Cells; Gene Expression; Humans; Lung Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Identification of benzo(a)pyrene diol epoxide-binding DNA fragments using DNA immunoprecipitation technique.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Blotting, Northern; Carcinogens; Cloning, Molecular; DNA; Esophageal Neoplasms; Esophagus; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Lung Neoplasms; Molecular Sequence Data; Precipitin Tests | 2003 |
Fas A670G polymorphism, apoptotic capacity in lymphocyte cultures, and risk of lung cancer.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Carcinogens; Case-Control Studies; Cells, Cultured; fas Receptor; Female; Flow Cytometry; Genotype; Humans; Lung Neoplasms; Lymphocytes; Male; Middle Aged; Pilot Projects; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors | 2003 |
[Study on lung carcinogenesis associated genes in human lung squamous cell carcinoma and malignant transformation of human bronchial epithelial cells induced by carcinogen].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Lung Neoplasms; Nickel; Oligonucleotide Array Sequence Analysis | 2003 |
Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Drug Interactions; Estrogen Antagonists; Fibroblasts; Gene Expression; Humans; Lung Neoplasms; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Receptors, Androgen; Testosterone; Tumor Cells, Cultured | 2004 |
High DNA damage by benzo[a]pyrene 7,8-diol-9,10-epoxide in bronchial epithelial cells from patients with lung cancer: comparison with lung parenchyma.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Bronchi; Carcinogens; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Epithelial Cells; Female; Humans; Lung Neoplasms; Male; Middle Aged | 2004 |
CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Genotype; Humans; Lung Neoplasms; Quercetin | 2005 |
Cell cycle checkpoints, DNA damage/repair, and lung cancer risk.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cell Cycle; DNA Damage; DNA Repair; Ethnicity; Female; Gamma Rays; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms, Radiation-Induced; Radionuclide Imaging; Reference Values; Risk Factors; Smoking | 2005 |
Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Alternative Splicing; Benzo(a)pyrene; Carcinoma; Cell Line; Enzyme Inhibitors; Female; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Alleviation of benzo[a]pyrene-diolepoxide-DNA damage in human lung carcinoma by glutathione S-transferase M2.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Cell Line, Tumor; DNA Adducts; DNA Damage; DNA Primers; Enzyme-Linked Immunosorbent Assay; Glutathione Transferase; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
[Roles of mutant p53 gene in malignant phenotypes and resistance to drugs in anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene-induced lung cancer cells].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Drug Resistance, Neoplasm; Genes, p53; Humans; Lung Neoplasms; Phenotype; Point Mutation; Transfection; Tumor Cells, Cultured | 2005 |
[Effect of heat and BPDE on the expression of Hsp27 and Hsp70 in A549 cell line].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Carcinogens; Cell Line, Tumor; Heat-Shock Proteins; Hot Temperature; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Lung Neoplasms; Molecular Chaperones | 2006 |
Estimating preventable fractions of disease caused by a specified biological mechanism: PAHs in smoking lung cancers as an example.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; DNA Adducts; Genes, p53; Humans; Lung Neoplasms; Models, Biological; Models, Statistical; Mutation; Polycyclic Aromatic Hydrocarbons; Risk Assessment; Smoking | 2006 |
Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Aged, 80 and over; Black or African American; Bleomycin; Case-Control Studies; DNA Breaks; Family Health; Female; Hispanic or Latino; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Mutagens; Odds Ratio; Risk Factors; Smoking; Surveys and Questionnaires; Texas; White People | 2007 |
A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adult; Aged; Alkylating Agents; Alkylation; Biological Assay; Carcinogens; Case-Control Studies; Cells, Cultured; DNA Damage; DNA Repair; Female; Humans; In Vitro Techniques; Lung Neoplasms; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Nitrosamines; Phytohemagglutinins; Pilot Projects; Plasmids; Risk Factors; Sulfuric Acid Esters | 2007 |
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenoma; Animals; Benzo(a)pyrene; Carcinogens; DNA Adducts; Female; Gene Expression Profiling; Glutathione S-Transferase pi; Lung; Lung Neoplasms; Male; MAP Kinase Kinase 4; Nicotiana; RNA, Messenger; Urethane | 2007 |
Benzo[a]pyrene-7,8-diol-9,10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Caspases; Cell Line, Transformed; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Knockout | 2007 |
[A cigarette, an aromatic...and a cancer].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens, Environmental; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Hot Temperature; Humans; Lung Neoplasms; Smoking; Structure-Activity Relationship; Substrate Specificity | 2008 |
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Benzo(a)pyrene; Biotransformation; Carcinogens, Environmental; DNA Adducts; DNA Mutational Analysis; Female; Fibroblasts; Humans; Immunohistochemistry; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Air Pollutants; Benzo(a)pyrene; Biomarkers; China; Coal; DNA; DNA Damage; Environmental Exposure; Environmental Monitoring; Female; Humans; Lung Neoplasms; Male; Polycyclic Compounds; Pregnancy | 1993 |
In vitro induction of benzo(a)pyrene diol epoxide-DNA adducts in peripheral lymphocytes as a susceptibility marker for human lung cancer.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Biomarkers; Case-Control Studies; Cells, Cultured; Disease Susceptibility; DNA Adducts; DNA Repair; Female; Humans; Lung Neoplasms; Lymphocytes; Male; Middle Aged; Risk Factors; Smoking | 1996 |
Benzo(a)pyrene diol epoxide-induced chromosomal aberrations and risk of lung cancer.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Aged, 80 and over; Carcinogens; Case-Control Studies; Cells, Cultured; Chromosome Aberrations; Female; Humans; Lung Neoplasms; Lymphocytes; Male; Middle Aged; Risk Factors | 1996 |
Reduced DNA repair capacity in lung cancer patients.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Age Factors; Aged; Cell Line; Chloramphenicol O-Acetyltransferase; Cytomegalovirus; DNA Damage; DNA Repair; Ethnicity; Female; Genes, Reporter; Humans; Lung Neoplasms; Lymphocytes; Male; Middle Aged; Mutagens; Reference Values; Risk Factors; Smoking | 1996 |
Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bronchi; Carcinogens; Cells, Cultured; Codon; Dinucleoside Phosphates; DNA Adducts; Exons; Fibroblasts; Genes, p53; HeLa Cells; Humans; Lung Neoplasms; Mutagens; Mutation; Nicotiana; Plants, Toxic; Smoke | 1996 |
Glutathione S-transferases of female A/J mouse lung and their induction by anticarcinogenic organosulfides from garlic.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Allyl Compounds; Amino Acid Sequence; Animals; Blotting, Western; Enzyme Induction; Female; Garlic; Glutathione Transferase; Isoenzymes; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Sequence Data; Plants, Medicinal; Propane; Sulfides | 1997 |
Flow cytometric measurement of benzo[a]pyrene-diol-epoxide-DNA adducts in normal human peripheral lymphocytes and cultured human lung cancer cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Carcinogens; Cell Cycle; Cell Fractionation; Cell Nucleus; DNA Adducts; Flow Cytometry; Humans; Lung Neoplasms; Lymphocytes; Male; Tumor Cells, Cultured | 1998 |
Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human, Pair 3; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Humans; In Situ Hybridization, Fluorescence; Interphase; Lung Neoplasms; Lymphocytes; Male; Middle Aged; Pilot Projects; Risk; Smoking | 1998 |
A parallel study of in vitro sensitivity to benzo[a]pyrene diol epoxide and bleomycin in lung carcinoma cases and controls.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Aged, 80 and over; Bleomycin; Carcinogenicity Tests; Carcinogens; Case-Control Studies; Chromatids; Chromosome Aberrations; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Lymphocytes; Male; Middle Aged; Tumor Cells, Cultured | 1998 |
Impact of adduct determination on the assessment of cancer susceptibility.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Cytochrome P-450 CYP1A1; Disease Susceptibility; DNA Adducts; Humans; Lung Neoplasms; Male; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Polymorphism, Genetic; Smoking | 1998 |
Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Biomarkers, Tumor; Cytochrome P-450 CYP1A1; DNA Adducts; DNA, Neoplasm; Genetic Predisposition to Disease; Glutathione Transferase; Humans; Leukocytes; Leukoplakia; Lung Neoplasms; Male; Occupational Exposure; Plants, Toxic; Polycyclic Aromatic Hydrocarbons; Polymerase Chain Reaction; Retrospective Studies; Smoking; Tobacco, Smokeless | 1999 |
Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Cytochrome P-450 CYP1A1; DNA Adducts; Genotype; Glutathione Transferase; Humans; Isoenzymes; Lung Neoplasms; Male; Multivariate Analysis; Occupational Exposure; Polymorphism, Genetic; Smoking | 2000 |
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bleomycin; Case-Control Studies; Chromosome Aberrations; Data Interpretation, Statistical; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Lung Neoplasms; Lymphocytes; Male; Mutagenicity Tests; Mutagens; Risk Factors; Somatomedins | 2000 |
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorometry; Inhibitory Concentration 50; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes, Liver | 2000 |
Human lung cancer and p53: the interplay between mutagenesis and selection.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Biomarkers, Tumor; Codon; Genes, p53; Humans; Lung Neoplasms; Mutation; Selection, Genetic; Smoking | 2000 |
Identification of benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine in human lung adenocarcinoma cells exposed to cooking oil fumes from frying fish under domestic conditions.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Air; Carcinogens; Chromatography, High Pressure Liquid; Cooking; Deoxyguanosine; DNA Adducts; Humans; Isotope Labeling; Lung Neoplasms; Mass Spectrometry; Oils; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons; Tumor Cells, Cultured | 2000 |
Assay for DNA damage using immunochemical recognition and capillary electrophoresis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Animals; Antibodies, Monoclonal; Bromodeoxyuridine; DNA Adducts; DNA Damage; DNA, Neoplasm; Electrophoresis, Capillary; Immunochemistry; Immunoglobulin G; Lung Neoplasms; Mice; Microscopy, Fluorescence; Plasmids; Sensitivity and Specificity; Skin; Tumor Cells, Cultured | 2001 |
Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens; Case-Control Studies; DNA Adducts; DNA Damage; DNA Repair; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged | 2001 |
The trouble with smoking.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Case-Control Studies; DNA Adducts; Genes, p53; Humans; Lung Neoplasms; Mutation; Smoking | 2000 |
Hydrocarbon carcinogens evade cellular defense mechanism of G1 arrest in nontransformed and malignant lung cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Antineoplastic Agents; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chrysenes; Dactinomycin; DNA Damage; Epithelial Cells; Flow Cytometry; G1 Phase; Genes, p53; Humans; Lung; Lung Neoplasms; Mice; Mutagens; Mutation; Nocodazole; Nucleic Acid Synthesis Inhibitors; Tumor Cells, Cultured | 2001 |
Gender difference in DNA adduct levels among nonsmoking lung cancer patients.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cytochrome P-450 CYP1A1; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Female; Glutathione Transferase; Humans; Lung Neoplasms; Male; Polymorphism, Genetic; Rabbits; Sex Factors; Smoking | 2001 |
Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adolescent; Adult; Aged; Carcinogens; Cells, Cultured; Child; Child, Preschool; Codon; Genes, p53; Humans; Infant; Lung; Lung Neoplasms; Middle Aged; Mutagenesis, Site-Directed; Mutagens; Mutation; Smoking | 2001 |
Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Bacterial Proteins; Base Sequence; Carcinogens; CpG Islands; DNA Adducts; DNA Methylation; Escherichia coli Proteins; Fibroblasts; Genes, p53; Genes, Suppressor; Genetic Vectors; Humans; Lac Repressors; Lung Neoplasms; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutagens; Repressor Proteins; RNA, Transfer; Smoking; Substrate Specificity; Transcription Factors; Transgenes; Viral Proteins | 2001 |
An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Fluorometry; Genetic Variation; Humans; Hydrolysis; Isotope Labeling; Lung; Lung Diseases; Lung Neoplasms; Male; Microsomes; Middle Aged; Phosphorus Radioisotopes; Radiometry; Smoking; Thymus Gland | 1992 |
Polycyclic aromatic hydrocarbon--DNA adducts in white blood cells from lung cancer patients: no correlation with adduct levels in lung.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Aged, 80 and over; Autoradiography; Chromatography, Thin Layer; DNA; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Female; Humans; Leukocytes; Lung; Lung Neoplasms; Male; Middle Aged; Smoking | 1992 |
Polycyclic aromatic hydrocarbon-DNA adducts in lung tissue from lung cancer patients.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Autoradiography; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; DNA, Neoplasm; Enzyme-Linked Immunosorbent Assay; Humans; Lung; Lung Neoplasms; Phosphorus Radioisotopes; Polycyclic Compounds; Smoking | 1990 |
Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antibodies; Benzopyrenes; Carcinogens, Environmental; Coal; Coke; DNA; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay; Epitopes; Lung Neoplasms; Lymphocytes; Occupational Diseases; Occupations; Polycyclic Compounds; Radioimmunoassay; Spectrometry, Fluorescence | 1985 |
Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carcinogens; Ellagic Acid; Female; Flavonoids; Lung Neoplasms; Mice; Mice, Inbred Strains; Quercetin; Skin Neoplasms | 1985 |
Validation of a new fluorometric assay for benzo[a]pyrene diolepoxide-DNA adducts in human white blood cells: comparisons with 32P-postlabeling and ELISA.
Topics: Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Fluorescence; Humans; Leukocytes; Lung Neoplasms; Phosphorus Radioisotopes; Sensitivity and Specificity | 1994 |
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk.
Topics: Antibiotics, Antineoplastic; Benzopyrenes; Bleomycin; Case-Control Studies; Cells, Cultured; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Lung Neoplasms; Mutagens; Odds Ratio; Risk Factors; Somatomedins | 2000 |
Synthesis, characterization, and applications of a fluorescent probe of DNA damage.
Topics: Antibodies; Benzopyrenes; DNA Damage; Electrophoresis; Fluorescent Dyes; Humans; Immunoassay; Lung Neoplasms; Oligonucleotides; Sensitivity and Specificity; Tumor Cells, Cultured | 2001 |