68ga-dotanoc and Sarcoidosis

Topics: Arteritis; Cardiomyopathies; Diagnosis, Differential; Fluorodeoxyglucose F18; Histiocytic Necrotizing Lymphadenitis; Humans; Lupus Erythematosus, Systemic; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Pulmonary Disease, Chronic Obstructive; Radiopharmaceuticals; Sarcoidosis; Sensitivity and Specificity; Thoracic Diseases

Cardiac sarcoidosis usually occurs as a manifestation of systemic sarcoidosis, even though isolated cardiac involvement is not uncommon. The usefulness of 68Ga-DOTANOC PET/CT in the diagnosis of CS has been previously documented in the literature. We present a case of cardiac sarcoidosis, where 68Ga-DOTANOC PET/CT was used for monitoring response to therapy.

Topics: Humans; Myocarditis; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Sarcoidosis

Topics: Adult; Cardiomyopathies; Humans; Male; Organometallic Compounds; Sarcoidosis; Technetium Tc 99m Sestamibi

We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity.. Patients diagnosed with sarcoidosis underwent Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. A SUVmax/SUVmed ratio (disease activity score) of more than one was considered a marker of active disease and was compared with the clinical symptoms and serum angiotensin-converting enzyme and computed tomography (CT) scan. The primary outcome was to assess the efficacy of the scan in estimating disease activity.. Of the 39 patients enrolled in the study, 27 patients were symptomatic and the rest were asymptomatic at enrollment. Increased disease activity was present in 25 (92%) of the 27 symptomatic patients and two (16%) of the 12 asymptomatic patients. The sensitivity and specificity of the test were 92.5% (95% confidence interval=75.7-99.0) and 83.3% (95% confidence interval=51.5-97.9), respectively. Seven out of nine patients who became asymptomatic after treatment showed a significant decrease in the mean disease activity score in post-treatment scans (3.38±1.05 vs 1.20±0.82, P<0.001).. Ga-DOTA-NOC PET/CT emerged as a useful tool to assess the disease activity and treatment response in patients with sarcoidosis with thoracic involvement.

Topics: Adult; Female; Humans; Male; Middle Aged; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Prognosis; Sarcoidosis