68ga-dotanoc and Osteomalacia

Tumor-induced osteomalacia is a rare paraneoplastic syndrome, usually caused by small benign mesenchymal tumors. The tumors most arise within the extremities, whereas occurrence within the parotid gland is quite rare. A 54-year-old woman who presented with bone pain and muscle weakness for 2 years was clinically suspected of having tumor-induced osteomalacia. A Ga-DOTANOC PET/CT was performed for localization of the causative tumor. The images demonstrated intense radiotracer accumulation in a soft tissue nodule in deep lobe of the right parotid gland. Subsequent surgical resection and pathologic analysis confirmed the diagnosis of parotid basal cell adenoma.

Topics: Adenoma; Female; Humans; Middle Aged; Neoplasms, Connective Tissue; Organometallic Compounds; Osteomalacia; Paraneoplastic Syndromes; Parotid Neoplasms; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals

Tumor-induced osteomalacia (TIO) is a rare disease entity characterized by clinical pictures of recurrent multiple fractures and biochemical features of phosphaturia, hypophosphatemia, and low vitamin D levels. Most often TIO is caused by benign soft tissue tumors. The main issue in management of such patients is proper tumor localization, as these tumors are small and often located at obscure sites. We describe a case of TIO where residual disease was clinically suspected after tumor resection and subsequently detected using Ga-DOTANOC PET/CT.

Topics: Humans; Male; Middle Aged; Multimodal Imaging; Neoplasm, Residual; Organometallic Compounds; Osteomalacia; Positron-Emission Tomography; Tomography, X-Ray Computed