68ga-dotanoc and Medulloblastoma

Medulloblastomas, especially the sonic hedgehog subgroup, are treated aggressively with surgery and chemoradiotherapy, as they are associated with high local site recurrence rate and poor overall survival. Radiation-induced meningioma is the most common delayed complication of craniospinal irradiation. This needs to be differentiated from meningeal or ependymal metastases as the later need aggressive management. We report one such rare case, in a patient who completed treatment for medulloblastoma 11 years ago, was in remission, and now presented with dural-based lesions.

Topics: Cerebellar Neoplasms; Humans; Medulloblastoma; Meningioma; Neoplasms, Radiation-Induced; Organometallic Compounds; Positron Emission Tomography Computed Tomography

We describe the utility of molecular imaging with 18F-FDG and 68Ga-DOTANOC PET for treatment response assessment in a case of metastatic medulloblastoma. 18F-FDG and 68Ga-DOTANOC PET/CT revealed extensive metastases to bone and bone marrow. Patient subsequently had an excellent response to systemic chemotherapy which was evidenced by resolution of tracer-avid skeletal lesions on both FDG and DOTANOC PET/CT.

Topics: Cerebellar Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Medulloblastoma; Neoplasm Metastasis; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Treatment Outcome

Medulloblastoma, also known as cerebellar primitive neuroectodermal tumor, is the most common brain tumor in children and arises in the posterior cranial fossa. We present the case of a patient with desmoplastic type of medulloblastoma, which showed recurrence more than once. When Ga-DOTANOC PET-CT was done, the lesions showed somatostatin receptor expression, opening another potential therapeutic option for this patient.

Topics: Adolescent; Cerebellar Neoplasms; Female; Humans; Medulloblastoma; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals