68ga-dotanoc and Carcinoma--Neuroendocrine

Neuroendocrine tumors (NETs) of the thyroid gland are generally considered to be derived from parafollicular endocrine or C cells and are known as medullary thyroid carcinomas. Non-calcitonin-producing NETs of the thyroid are extremely rare in occurrence and pose a significant diagnostic dilemma for the physician and pathologist. We describe a case of a 58-year-old woman who was diagnosed as having primary NET thyroid with normal calcitonin levels and Ga DOTANOC PET-CT scan findings which were done for initial extent evaluation of the disease.

Topics: Calcitonin; Carcinoma, Neuroendocrine; Humans; Male; Middle Aged; Neuroendocrine Tumors; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Thyroid Neoplasms

Ectopic Cushing syndrome constitutes approximately 10% of all patients with Cushing syndrome. The clinical features of hypercortisolism result from elevated levels of adrenocorticotropic hormone produced by a tumor. The present case presented with clinical and biochemical parameters suggestive of Cushing syndrome with normal pituitary and adrenals on imaging. Ga-DOTANOC PET/CT done to localize an ectopic adrenocorticotropic hormone-producing tumor revealed metastatic medullary carcinoma of the thyroid as the culprit lesion.

Topics: Adrenocorticotropic Hormone; Carcinoma, Neuroendocrine; Cushing Syndrome; Humans; Male; Middle Aged; Neoplasm Metastasis; Organometallic Compounds; Positron Emission Tomography Computed Tomography; Thyroid Neoplasms

Neuroendocrine tumors constitute a heterogeneous group of neoplasms arising from the cells of the neural crest. We present a rare case of primary sinonasal neuroendocrine carcinoma in a 61-year-old male patient where somatostatin receptor PET/CT with 68Ga-DOTANOC correctly delineated the extent of primary tumor as compared to contrast-enhanced CT, thereby changing patient management.

Topics: Carcinoma, Neuroendocrine; Carcinoma, Small Cell; Humans; Male; Maxillary Sinus Neoplasms; Middle Aged; Organometallic Compounds; Positron-Emission Tomography; Tomography, X-Ray Computed

A patient with a history of radical thyroidectomy for medullary thyroid carcinoma (MTC) was studied by 68Ga [DOTA,1-Nal3]octreotide PET/CT for suspected relapse. PET/CT documented a focal area of somatostatin receptors expression at bone level. Although 68Ga DOTA-peptides PET has been successfully used for the detection of neuroendocrine tumors, its role in MTC patients is still under evaluation. In fact, although deriving from the neural crest, MTC cells may show a variable expression of somatostatin receptors. This case shows that PET/CT with DOTANOC may be a useful complementary imaging modality in patients with well-differentiated MTC.

Topics: Bone Neoplasms; Carcinoma, Neuroendocrine; Female; Humans; Middle Aged; Multimodal Imaging; Organometallic Compounds; Positron-Emission Tomography; Recurrence; Thyroid Neoplasms; Tomography, X-Ray Computed

PET/CT imaging using Ga-labeled somatostatin analogs has become a popular noninvasive diagnostic modality in the workup of patients with neuroendocrine tumors. A 65-year-old man with pancreatic neuroendocrine tumor with confirmed liver metastases on conventional imaging underwent restaging Ga-DOTANOC PET/CT to monitor response to cold octreotide therapy. Previous PET/CT had shown presence of multiple liver and skeletal metastases along with a primary pancreatic tumor showing intense tracer uptake. The present PET/CT study showed an increase in number and uptake of the metastatic lesions suggestive of progressive disease resulting in the appearance of a superscan.

Topics: Aged; Carcinoma, Neuroendocrine; Humans; Male; Multimodal Imaging; Neoplasm Metastasis; Organometallic Compounds; Positron-Emission Tomography; Receptors, Somatostatin; Tomography, X-Ray Computed

Topics: Carcinoma, Neuroendocrine; Gallium Radioisotopes; Humans; Middle Aged; Organometallic Compounds; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Somatostatin