6-o-angeloylprenolin has been researched along with Inflammation* in 2 studies
2 other study(ies) available for 6-o-angeloylprenolin and Inflammation
| Article | Year |
|---|---|
Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway.
Topics: Animals; Chondrocytes; Disease Models, Animal; Ferroptosis; Humans; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Menisci, Tibial; Mice; NF-E2-Related Factor 2; Osteoarthritis; Quality of Life; Signal Transduction; Sirtuin 1 | 2023 |
6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo.
Neuroinflammation is one of the critical events in neurodegenerative diseases, whereas microglia play an important role in the pathogenesis of neuroinflammation. In this study, we investigated the effects of a natural sesquiterpene lactone, 6-O-angeloylplenolin (6-OAP), isolated from the traditional Chinese medicine Centipeda minima (L.) A.Br., on neuroinflammation and the underlying mechanisms. We showed that treatment with lipopolysaccharide (LPS) caused activation of BV2 and primary microglial cells and development of neuroinflammation in vitro, evidenced by increased production of inflammatory cytokines TNF-α and IL-1β, the phosphorylation and nuclear translocation of NF-κB, and the transcriptional upregulation of COX-2 and iNOS, leading to increased production of proinflammatory factors NO and PGE Topics: Animals; Asteraceae; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Inflammation; Lactones; Lipopolysaccharides; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Molecular Conformation; Neurodegenerative Diseases; Neuroprotective Agents; Nitric Oxide; Oxidation-Reduction; Sesquiterpenes | 2020 |