6-methylthiopurine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 10 studies
6-methylthiopurine : A thiopurine that is 9H-purine substituted by a methylsulfanyl group at position 6.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Higher 6-MP dosage was associated with higher TPMT activity (P = 0." | 2.70 | Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine. ( Dervieux, T; Duval, M; Guigonis, V; Jacqz-Aigrain, E; Lescoeur, B; Médard, Y; Suciu, S; Verpillat, P; Vilmer, E, 2001) |
| "6-mercaptopurine is a mainstay of acute lymphoblastic leukemia treatment." | 1.72 | Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia. ( Alexander, TB; Geib, KB; Gold, S; Newcome, J; Thompson, P, 2022) |
| " Population pharmacokinetic analysis was performed with the nonlinear mixed effects modelling program (nonmem) to determine the population mean parameter estimate of clearance for the active metabolites." | 1.35 | Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia. ( Cairns, C; Collier, PS; Dempsey, S; Hawwa, AF; McCarthy, A; McElnay, JC; Millership, JS, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Newcome, J | 1 |
| Geib, KB | 1 |
| Thompson, P | 1 |
| Gold, S | 1 |
| Alexander, TB | 1 |
| Marinaki, AM | 1 |
| Arenas-Hernandez, M | 1 |
| Moon, SY | 1 |
| Lim, JH | 1 |
| Kim, EH | 1 |
| Nam, Y | 1 |
| Yu, KS | 1 |
| Hong, KT | 1 |
| Choi, JY | 1 |
| Hong, CR | 1 |
| Kim, H | 1 |
| Kang, HJ | 1 |
| Shin, HY | 1 |
| Lee, K | 1 |
| Song, J | 1 |
| Lee, SY | 1 |
| Song, SH | 1 |
| Brackett, J | 1 |
| Schafer, ES | 1 |
| Leung, DH | 1 |
| Bernhardt, MB | 1 |
| Hawwa, AF | 1 |
| Collier, PS | 1 |
| Millership, JS | 1 |
| McCarthy, A | 1 |
| Dempsey, S | 1 |
| Cairns, C | 1 |
| McElnay, JC | 1 |
| Wang, CC | 1 |
| Chiou, SS | 1 |
| Wu, SM | 1 |
| Welch, J | 1 |
| Lennard, L | 1 |
| Morton, GC | 1 |
| Lilleyman, JS | 1 |
| Mawatari, H | 1 |
| Kato, Y | 1 |
| Nishimura, S | 1 |
| Sakura, N | 1 |
| Ueda, K | 1 |
| Chrzanowska, M | 1 |
| Kolecki, P | 1 |
| Duczmal-Cichocka, B | 1 |
| Fiet, J | 1 |
| Dervieux, T | 1 |
| Médard, Y | 1 |
| Verpillat, P | 1 |
| Guigonis, V | 1 |
| Duval, M | 1 |
| Lescoeur, B | 1 |
| Suciu, S | 1 |
| Vilmer, E | 1 |
| Jacqz-Aigrain, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL[NCT02046694] | Early Phase 1 | 34 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 6-methylthiopurine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Reducing risk in thiopurine therapy.
Topics: Azathioprine; Drug Hypersensitivity; Erythrocytes; Female; Genotype; Humans; Male; Mercaptopurine; M | 2020 |
2 trials available for 6-methylthiopurine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Metabolites of mercaptopurine in red blood cells: a relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; | 1999 |
Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Dr | 2001 |
7 other studies available for 6-methylthiopurine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia.
Topics: Allopurinol; Burkitt Lymphoma; Child; Exanthema; Humans; Mercaptopurine; Precursor Cell Lymphoblasti | 2022 |
Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, Liquid; Erythr | 2019 |
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Proto | 2014 |
Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; | 2008 |
Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.
Topics: Electrophoresis, Capillary; Guanosine; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia | 2005 |
Pharmacokinetics of mercaptopurine: plasma drug and red cell metabolite concentrations after an oral dose.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female | 1997 |
Reversed-phase high-performance liquid chromatographic assay method for quantitating 6-mercaptopurine and its methylated and non-methylated metabolites in a single sample.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Erythrocytes; Hemoglobins; Hu | 1998 |