6-methylthiopurine has been researched along with Hepatitis, Autoimmune in 8 studies
6-methylthiopurine : A thiopurine that is 9H-purine substituted by a methylsulfanyl group at position 6.
Hepatitis, Autoimmune: A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ten percent of patients with autoimmune hepatitis (AIH) are nonresponsive or intolerant to thiopurine therapy." | 1.39 | Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis. ( Bouma, G; de Boer, NK; de Boer, YS; Mulder, CJ; van Gerven, NM; van Nieuwkerk, CM, 2013) |
| "Azathioprine dosage was significantly related to 6-TGN and 6-MeMPN levels (r = 0." | 1.36 | Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis. ( Boulieu, R; Daubard, M; Lachaux, A; Larger, M; Le Gall, C; Nguyen, TM, 2010) |
| "Azathioprine treatment is a long-term therapy and therefore it is at risk for non-adherence, which is considered an important determinant of treatment inefficacy." | 1.36 | Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence. ( Bartoli, F; Campanozzi, A; Decorti, G; Londero, M; Malusa, N; Marino, S; Martelossi, S; Stocco, G; Ventura, A, 2010) |
| "Azathioprine is a key drug in the management of autoimmune hepatitis (AIH), with effects mediated via conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP), the latter controlled by thiopurine methyltransferase (TPMT)." | 1.33 | Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. ( Allan, ML; Bornstein, JD; Heneghan, MA; Muir, AJ; Tendler, DA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bolia, R | 1 |
| Rajanayagam, J | 1 |
| Hardikar, W | 1 |
| Chua, EW | 1 |
| Cree, S | 1 |
| Barclay, ML | 1 |
| Doudney, K | 1 |
| Lehnert, K | 1 |
| Aitchison, A | 1 |
| Kennedy, MA | 1 |
| Alvarez Beltran, M | 1 |
| Infante Pina, D | 1 |
| Tormo Carnicé, R | 1 |
| Segarra Cantón, O | 1 |
| Redecillas Ferreiro, S | 1 |
| Nguyen, TM | 1 |
| Daubard, M | 1 |
| Le Gall, C | 1 |
| Larger, M | 1 |
| Lachaux, A | 1 |
| Boulieu, R | 1 |
| Stocco, G | 1 |
| Londero, M | 1 |
| Campanozzi, A | 1 |
| Martelossi, S | 1 |
| Marino, S | 1 |
| Malusa, N | 1 |
| Bartoli, F | 1 |
| Decorti, G | 1 |
| Ventura, A | 1 |
| de Boer, YS | 1 |
| van Gerven, NM | 1 |
| de Boer, NK | 1 |
| Mulder, CJ | 1 |
| Bouma, G | 1 |
| van Nieuwkerk, CM | 1 |
| Wusk, B | 1 |
| Kullak-Ublick, GA | 1 |
| Rammert, C | 1 |
| von Eckardstein, A | 1 |
| Fried, M | 1 |
| Rentsch, KM | 1 |
| Heneghan, MA | 1 |
| Allan, ML | 1 |
| Bornstein, JD | 1 |
| Muir, AJ | 1 |
| Tendler, DA | 1 |
8 other studies available for 6-methylthiopurine and Hepatitis, Autoimmune
| Article | Year |
|---|---|
Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis.
Topics: Allopurinol; Antimetabolites; Azathioprine; Child; Female; Guanine Nucleotides; Hepatitis, Autoimmun | 2018 |
Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Comparative Genomic Hybridization; Crohn Disease; DNA Copy | 2015 |
[Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].
Topics: Adolescent; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Inflammat | 2009 |
Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Biotransformation; Bloo | 2010 |
Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Guanine Nucleotides; Hepatitis, Autoimmun | 2010 |
Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis.
Topics: Adult; Aged; Alanine Transaminase; Allopurinol; Antimetabolites; Drug Interactions; Drug Therapy, Co | 2013 |
Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studi | 2004 |
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Drug Monitoring; Female; Genotype; | 2006 |