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6-methylthiopurine and Hepatitis, Autoimmune

6-methylthiopurine has been researched along with Hepatitis, Autoimmune in 8 studies

6-methylthiopurine : A thiopurine that is 9H-purine substituted by a methylsulfanyl group at position 6.

Hepatitis, Autoimmune: A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.

Research Excerpts

ExcerptRelevanceReference
"Ten percent of patients with autoimmune hepatitis (AIH) are nonresponsive or intolerant to thiopurine therapy."1.39Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis. ( Bouma, G; de Boer, NK; de Boer, YS; Mulder, CJ; van Gerven, NM; van Nieuwkerk, CM, 2013)
"Azathioprine dosage was significantly related to 6-TGN and 6-MeMPN levels (r = 0."1.36Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis. ( Boulieu, R; Daubard, M; Lachaux, A; Larger, M; Le Gall, C; Nguyen, TM, 2010)
"Azathioprine treatment is a long-term therapy and therefore it is at risk for non-adherence, which is considered an important determinant of treatment inefficacy."1.36Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence. ( Bartoli, F; Campanozzi, A; Decorti, G; Londero, M; Malusa, N; Marino, S; Martelossi, S; Stocco, G; Ventura, A, 2010)
"Azathioprine is a key drug in the management of autoimmune hepatitis (AIH), with effects mediated via conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP), the latter controlled by thiopurine methyltransferase (TPMT)."1.33Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. ( Allan, ML; Bornstein, JD; Heneghan, MA; Muir, AJ; Tendler, DA, 2006)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bolia, R1
Rajanayagam, J1
Hardikar, W1
Chua, EW1
Cree, S1
Barclay, ML1
Doudney, K1
Lehnert, K1
Aitchison, A1
Kennedy, MA1
Alvarez Beltran, M1
Infante Pina, D1
Tormo Carnicé, R1
Segarra Cantón, O1
Redecillas Ferreiro, S1
Nguyen, TM1
Daubard, M1
Le Gall, C1
Larger, M1
Lachaux, A1
Boulieu, R1
Stocco, G1
Londero, M1
Campanozzi, A1
Martelossi, S1
Marino, S1
Malusa, N1
Bartoli, F1
Decorti, G1
Ventura, A1
de Boer, YS1
van Gerven, NM1
de Boer, NK1
Mulder, CJ1
Bouma, G1
van Nieuwkerk, CM1
Wusk, B1
Kullak-Ublick, GA1
Rammert, C1
von Eckardstein, A1
Fried, M1
Rentsch, KM1
Heneghan, MA1
Allan, ML1
Bornstein, JD1
Muir, AJ1
Tendler, DA1

Other Studies

8 other studies available for 6-methylthiopurine and Hepatitis, Autoimmune

ArticleYear
Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis.
    Journal of pediatric gastroenterology and nutrition, 2018, Volume: 67, Issue:6

    Topics: Allopurinol; Antimetabolites; Azathioprine; Child; Female; Guanine Nucleotides; Hepatitis, Autoimmun

2018
Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers.
    The pharmacogenomics journal, 2015, Volume: 15, Issue:5

    Topics: Adult; Azathioprine; Colitis, Ulcerative; Comparative Genomic Hybridization; Crohn Disease; DNA Copy

2015
[Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].
    Anales de pediatria (Barcelona, Spain : 2003), 2009, Volume: 70, Issue:2

    Topics: Adolescent; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Inflammat

2009
Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.
    Therapeutic drug monitoring, 2010, Volume: 32, Issue:4

    Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Biotransformation; Bloo

2010
Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.
    Journal of Crohn's & colitis, 2010, Volume: 4, Issue:5

    Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Guanine Nucleotides; Hepatitis, Autoimmun

2010
Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis.
    Alimentary pharmacology & therapeutics, 2013, Volume: 37, Issue:6

    Topics: Adult; Aged; Alanine Transaminase; Allopurinol; Antimetabolites; Drug Interactions; Drug Therapy, Co

2013
Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.
    European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:12

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studi

2004
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.
    Journal of hepatology, 2006, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Drug Monitoring; Female; Genotype;

2006