6-methylthiopurine has been researched along with Colitis Gravis in 15 studies
6-methylthiopurine : A thiopurine that is 9H-purine substituted by a methylsulfanyl group at position 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For patients with severe ulcerative colitis (UC), steroid dosing has been clarified, and a mega-analysis of steroid outcomes and toxicities has been reported." | 2.44 | Optimizing drug therapy in inflammatory bowel disease. ( Kornbluth, A; Swaminath, A, 2007) |
| "We assessed the incidence and predictive factors of thiopurine-induced adverse events (AE) resulting in therapy cessation in pediatric inflammatory bowel disease (IBD), related to thiopurine metabolites and biochemical abnormalities, and determined overall drug survival." | 1.72 | Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study. ( Benninga, MA; Buiter, HJC; de Boer, NKH; de Meij, TGJ; Jagt, JZ; Pothof, CD; van Limbergen, JE; van Wijk, MP, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martín-Masot, R | 1 |
| Ortiz Pérez, MP | 1 |
| Ramos Rueda, N | 1 |
| Serrano Nieto, J | 1 |
| Blasco-Alonso, J | 1 |
| Navas-López, VM | 1 |
| Thomsen, SB | 1 |
| Allin, KH | 1 |
| Burisch, J | 1 |
| Jensen, CB | 1 |
| Hansen, S | 1 |
| Gluud, LL | 1 |
| Theede, K | 1 |
| Kiszka-Kanowitz, M | 1 |
| Nielsen, AM | 1 |
| Jess, T | 1 |
| Jagt, JZ | 1 |
| Pothof, CD | 1 |
| Buiter, HJC | 1 |
| van Limbergen, JE | 1 |
| van Wijk, MP | 1 |
| Benninga, MA | 1 |
| de Boer, NKH | 1 |
| de Meij, TGJ | 1 |
| Ihekweazu, FD | 1 |
| Kellermayer, R | 1 |
| Tack, GJ | 1 |
| Waayenberg, P | 1 |
| de Boer, NK | 2 |
| Kopylov, U | 1 |
| Battat, R | 1 |
| Benmassaoud, A | 1 |
| Paradis-Surprenant, L | 1 |
| Seidman, EG | 1 |
| Chua, EW | 1 |
| Cree, S | 1 |
| Barclay, ML | 1 |
| Doudney, K | 1 |
| Lehnert, K | 1 |
| Aitchison, A | 1 |
| Kennedy, MA | 1 |
| Rahhal, RM | 1 |
| Bishop, WP | 2 |
| Haines, ML | 1 |
| Ajlouni, Y | 1 |
| Irving, PM | 1 |
| Sparrow, MP | 1 |
| Rose, R | 1 |
| Gearry, RB | 1 |
| Gibson, PR | 1 |
| Hoentjen, F | 1 |
| Hanauer, SB | 1 |
| Rubin, DT | 1 |
| Wright, S | 1 |
| Sanders, DS | 1 |
| Lobo, AJ | 1 |
| Lennard, L | 1 |
| Goldenberg, BA | 1 |
| Rawsthorne, P | 1 |
| Bernstein, CN | 1 |
| Wusk, B | 1 |
| Kullak-Ublick, GA | 1 |
| Rammert, C | 1 |
| von Eckardstein, A | 1 |
| Fried, M | 1 |
| Rentsch, KM | 1 |
| Banerjee, S | 1 |
| Swaminath, A | 1 |
| Kornbluth, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL[NCT02046694] | Early Phase 1 | 34 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| Manitoba Inflammatory Bowel Disease Cohort Study[NCT03262649] | 388 participants (Actual) | Observational | 2002-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 6-methylthiopurine and Colitis Gravis
| Article | Year |
|---|---|
Optimizing drug therapy in inflammatory bowel disease.
Topics: Absorptiometry, Photon; Adalimumab; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal | 2007 |
14 other studies available for 6-methylthiopurine and Colitis Gravis
| Article | Year |
|---|---|
[Laboratory determination of thiopurine levels in paediatric patients with inflammatory bowel disease].
Topics: Adolescent; Child; Child, Preschool; Chromatography, Liquid; Colitis, Ulcerative; Crohn Disease; Dos | 2020 |
Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease: A nationwide Danish cohort study.
Topics: Adult; Allopurinol; Azathioprine; Colitis, Ulcerative; Crohn Disease; Denmark; Drug Therapy, Combina | 2020 |
Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study.
Topics: Adolescent; Antimetabolites; Azathioprine; Biomarkers, Pharmacological; Child; Cohort Studies; Colit | 2022 |
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era.
Topics: Adolescent; Allopurinol; Antimetabolites; Child; Colitis, Ulcerative; Drug Therapy, Combination; Fem | 2014 |
Beneficial pharmacological interaction between thiopurine and mesalazine—never change a winning team.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Interactions; Erythrocytes | 2014 |
Hematologic indices as surrogate markers for monitoring thiopurine therapy in IBD.
Topics: Anti-Inflammatory Agents; Azathioprine; Biomarkers; Colitis, Ulcerative; Crohn Disease; Cross-Sectio | 2015 |
Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Comparative Genomic Hybridization; Crohn Disease; DNA Copy | 2015 |
Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease.
Topics: Adolescent; Allopurinol; Antimetabolites; Child; Child, Preschool; Cohort Studies; Colitis, Ulcerati | 2008 |
Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Azathioprine; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Cr | 2011 |
Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.
Topics: Allopurinol; Antimetabolites; Colitis, Ulcerative; Dose-Response Relationship, Drug; Drug Therapy, C | 2012 |
Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antimetabolites, Antineoplastic; Azathioprine; Child; | 2004 |
The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease.
Topics: Adult; Azathioprine; Biomarkers; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Dose-Response R | 2004 |
Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studi | 2004 |
Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Erythr | 2006 |