6-methylthiopurine has been researched along with Acute Lymphoid Leukemia in 10 studies
6-methylthiopurine : A thiopurine that is 9H-purine substituted by a methylsulfanyl group at position 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Higher 6-MP dosage was associated with higher TPMT activity (P = 0." | 2.70 | Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine. ( Dervieux, T; Duval, M; Guigonis, V; Jacqz-Aigrain, E; Lescoeur, B; Médard, Y; Suciu, S; Verpillat, P; Vilmer, E, 2001) |
| "6-mercaptopurine is a mainstay of acute lymphoblastic leukemia treatment." | 1.72 | Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia. ( Alexander, TB; Geib, KB; Gold, S; Newcome, J; Thompson, P, 2022) |
| " Population pharmacokinetic analysis was performed with the nonlinear mixed effects modelling program (nonmem) to determine the population mean parameter estimate of clearance for the active metabolites." | 1.35 | Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia. ( Cairns, C; Collier, PS; Dempsey, S; Hawwa, AF; McCarthy, A; McElnay, JC; Millership, JS, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Newcome, J | 1 |
| Geib, KB | 1 |
| Thompson, P | 1 |
| Gold, S | 1 |
| Alexander, TB | 1 |
| Marinaki, AM | 1 |
| Arenas-Hernandez, M | 1 |
| Moon, SY | 1 |
| Lim, JH | 1 |
| Kim, EH | 1 |
| Nam, Y | 1 |
| Yu, KS | 1 |
| Hong, KT | 1 |
| Choi, JY | 1 |
| Hong, CR | 1 |
| Kim, H | 1 |
| Kang, HJ | 1 |
| Shin, HY | 1 |
| Lee, K | 1 |
| Song, J | 1 |
| Lee, SY | 1 |
| Song, SH | 1 |
| Brackett, J | 1 |
| Schafer, ES | 1 |
| Leung, DH | 1 |
| Bernhardt, MB | 1 |
| Hawwa, AF | 1 |
| Collier, PS | 1 |
| Millership, JS | 1 |
| McCarthy, A | 1 |
| Dempsey, S | 1 |
| Cairns, C | 1 |
| McElnay, JC | 1 |
| Wang, CC | 1 |
| Chiou, SS | 1 |
| Wu, SM | 1 |
| Welch, J | 1 |
| Lennard, L | 1 |
| Morton, GC | 1 |
| Lilleyman, JS | 1 |
| Mawatari, H | 1 |
| Kato, Y | 1 |
| Nishimura, S | 1 |
| Sakura, N | 1 |
| Ueda, K | 1 |
| Chrzanowska, M | 1 |
| Kolecki, P | 1 |
| Duczmal-Cichocka, B | 1 |
| Fiet, J | 1 |
| Dervieux, T | 1 |
| Médard, Y | 1 |
| Verpillat, P | 1 |
| Guigonis, V | 1 |
| Duval, M | 1 |
| Lescoeur, B | 1 |
| Suciu, S | 1 |
| Vilmer, E | 1 |
| Jacqz-Aigrain, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL[NCT02046694] | Early Phase 1 | 34 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 6-methylthiopurine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Reducing risk in thiopurine therapy.
Topics: Azathioprine; Drug Hypersensitivity; Erythrocytes; Female; Genotype; Humans; Male; Mercaptopurine; M | 2020 |
2 trials available for 6-methylthiopurine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Metabolites of mercaptopurine in red blood cells: a relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; | 1999 |
Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Dr | 2001 |
7 other studies available for 6-methylthiopurine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia.
Topics: Allopurinol; Burkitt Lymphoma; Child; Exanthema; Humans; Mercaptopurine; Precursor Cell Lymphoblasti | 2022 |
Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, Liquid; Erythr | 2019 |
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Proto | 2014 |
Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; | 2008 |
Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.
Topics: Electrophoresis, Capillary; Guanosine; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia | 2005 |
Pharmacokinetics of mercaptopurine: plasma drug and red cell metabolite concentrations after an oral dose.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female | 1997 |
Reversed-phase high-performance liquid chromatographic assay method for quantitating 6-mercaptopurine and its methylated and non-methylated metabolites in a single sample.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Erythrocytes; Hemoglobins; Hu | 1998 |