6-methylsulfinylhexyl-isothiocyanate and Inflammation

Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer's disease (AD), AD model

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Calcium-Binding Proteins; Cognition; Cognitive Dysfunction; Disease Models, Animal; Glutathione; Inflammation; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylethanolamines; Plaque, Amyloid; Plasmalogens; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Alzheimer's disease (AD) is the most common form of dementia among older people. Although soluble amyloid species are recognized triggers of the disease, no therapeutic approach is able to stop it. 6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in Wasabia japonica, which is a typical Japanese pungent spice. Recently, in vivo and in vitro studies demonstrated that 6-MSITC has several biological properties. The aim of the present study was to investigate the neuroprotective activity of 6-MSITC in a murine AD model, induced by intracerebroventricular injection of β-amyloid oligomers (Aβ

Topics: Amyloid beta-Peptides; Animals; Apoptosis; Caspases; Cell Death; Cognition Disorders; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3 beta; Hippocampus; Inflammation; Isothiocyanates; Mice; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Phosphorylation