6-methyl-2-(phenylethynyl)pyridine has been researched along with Facial-Pain* in 2 studies
2 other study(ies) available for 6-methyl-2-(phenylethynyl)pyridine and Facial-Pain
| Article | Year |
|---|---|
A role for the purinergic receptor P2X
The purinergic receptor P2X Topics: Animals; Astrocytes; Brain Stem; Disease Models, Animal; Facial Pain; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Microscopy, Electron; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X3 | 2017 |
Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats.
The present study investigated the role of peripheral group I metabotropic glutamate receptors (mGluRs) in MO-induced nociceptive behaviour and inflammation in the masseter muscles of lightly anesthetized rats. Experiments were carried out on male Sprague-Dawley rats weighing 300-400 g. After initial anesthesia with sodium pentobarbital (40 mg/kg, i.p.), one femoral vein was cannulated and connected to an infusion pump for intravenous infusion of sodium pentobarbital. The rate of infusion was adjusted to provide a constant level of anesthesia. Mustard oil (MO, 30 microl) was injected into the mid-region of the left masseter muscle via a 30-gauge needle over 10s. After 30 microl injection of 5, 10, 15, or 20% MO into the masseter muscle, the total number of hindpaw shaking behaviour and extravasated Evans' blue dye concentration in the masseter muscle were significantly higher in the MO-treated group in a dose-dependent manner compared with the vehicle (mineral oil)-treated group. Intramuscular pretreatment with 3 or 5% lidocaine reduced MO-induced hindpaw shaking behaviour and increases in extravasated Evans' blue dye concentration. Intramuscular pretreatment with 5 mM MCPG, non-selective group I/II mGluR antagonist, or MPEP, a selective group I mGluR5 antagonist, produced a significant attenuation of MO-induced hindpaw shaking behaviour and increases in extravasated Evans' blue dye concentration in the masseter muscle while LY367385, a selective group I mGluR1 antagonist, did not affect MO-induced nociceptive behaviour and inflammation in the masseter muscle. These results indicate that peripheral mGluR5 plays important role in mediating MO-induced nociceptive behaviour and inflammation in the craniofacial muscle. Topics: Anesthetics, Local; Animals; Behavior, Animal; Benzoates; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Facial Muscles; Facial Pain; Functional Laterality; Glycine; Inflammation; Lidocaine; Male; Mustard Plant; Pain Measurement; Plant Oils; Pyridines; Rats; Rats, Sprague-Dawley | 2006 |