Compounds > 6-methyl-2-(phenylethynyl)pyridine

6-methyl-2-(phenylethynyl)pyridine and Epilepsy--Tonic-Clonic

6-methyl-2-(phenylethynyl)pyridine has been researched along with Epilepsy--Tonic-Clonic* in 2 studies

Other Studies

2 other study(ies) available for 6-methyl-2-(phenylethynyl)pyridine and Epilepsy--Tonic-Clonic

Article	Year
Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures. Bulletin of experimental biology and medicine, 2015, Volume: 159, Issue:1 Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of seizure and partially prevented increased generation of NO due to acoustic stimulation. These data indicate that mGlu receptors and NO play an important role in the pathogenetic mechanisms of audiogenic seizures. Topics: Acoustic Stimulation; Animals; Cerebral Cortex; Electron Spin Resonance Spectroscopy; Epilepsy, Reflex; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Indans; Male; Nerve Tissue Proteins; Nitric Oxide; Pyridines; Rats; Rats, Mutant Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate	2015
MPEP, an antagonist of metabotropic glutamate receptors, exhibits anticonvulsant action in immature rats without a serious impairment of motor performance. Epilepsy research, 2004, Volume: 60, Issue:1 An antagonist of type I metabotropic glutamate receptors MPEP was found to exhibit anticonvulsant action in adult rodents. Present experiments were focused on action of this drug against pentetrazol-induced motor seizures in immature rats 12-, 18- and 25-days old. Dose of pentetrazol (100 mg/kg s.c.) was chosen to elicit minimal clonic seizures and (after a longer latency) generalized tonic-clonic seizures. Pretreatment with MPEP (doses from 10 to 80 mg/kg i.p.) resulted in a dose-dependent suppression of the tonic phase of generalized tonic-clonic seizures in all age groups studied. Efficacy of MPEP was higher and the effect lasted longer in 12- than in 25-day-old rats. In addition, minimal clonic seizures were suppressed in 18-day-old rats. Motor abilities of immature animals were not compromised by MPEP in doses of 20 and/or 40 mg/kg i.p., only righting reflex was a little slowed down in 12- and 18-day-old rats. In contrast to antagonists of ionotropic glutamate receptors anticonvulsant doses of MPEP do not induce unwanted side effects in motor performance of developing rats. Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Male; Motor Activity; Pentylenetetrazole; Postural Balance; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reflex	2004

Article

Year

Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures.

Bulletin of experimental biology and medicine, 2015, Volume: 159, Issue:1

Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of seizure and partially prevented increased generation of NO due to acoustic stimulation. These data indicate that mGlu receptors and NO play an important role in the pathogenetic mechanisms of audiogenic seizures.

Topics: Acoustic Stimulation; Animals; Cerebral Cortex; Electron Spin Resonance Spectroscopy; Epilepsy, Reflex; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Indans; Male; Nerve Tissue Proteins; Nitric Oxide; Pyridines; Rats; Rats, Mutant Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2015

MPEP, an antagonist of metabotropic glutamate receptors, exhibits anticonvulsant action in immature rats without a serious impairment of motor performance.

Epilepsy research, 2004, Volume: 60, Issue:1

An antagonist of type I metabotropic glutamate receptors MPEP was found to exhibit anticonvulsant action in adult rodents. Present experiments were focused on action of this drug against pentetrazol-induced motor seizures in immature rats 12-, 18- and 25-days old. Dose of pentetrazol (100 mg/kg s.c.) was chosen to elicit minimal clonic seizures and (after a longer latency) generalized tonic-clonic seizures. Pretreatment with MPEP (doses from 10 to 80 mg/kg i.p.) resulted in a dose-dependent suppression of the tonic phase of generalized tonic-clonic seizures in all age groups studied. Efficacy of MPEP was higher and the effect lasted longer in 12- than in 25-day-old rats. In addition, minimal clonic seizures were suppressed in 18-day-old rats. Motor abilities of immature animals were not compromised by MPEP in doses of 20 and/or 40 mg/kg i.p., only righting reflex was a little slowed down in 12- and 18-day-old rats. In contrast to antagonists of ionotropic glutamate receptors anticonvulsant doses of MPEP do not induce unwanted side effects in motor performance of developing rats.

Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Male; Motor Activity; Pentylenetetrazole; Postural Balance; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reflex

2004