6-ketoprostaglandin-f1-alpha has been researched along with Pneumonia--Pneumococcal* in 2 studies
2 other study(ies) available for 6-ketoprostaglandin-f1-alpha and Pneumonia--Pneumococcal
| Article | Year |
|---|---|
[Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia].
To study the pathogenic mechanism underlying intestinal injury in the aged rat with pneumonia.. The model of rats with pneumococcus pneumonia was reproduced, and animals were divided into young control group (YCG), young model group (YMG), aged control group (ACG) and aged model group (AMG). The pathological change of lung tissue and intestine, contents of intestinal 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)), thromboxane B(2) (TXB(2)), nitric oxide (NO), malondialdehyde (MDA) and superoxide dismutase (SOD) activity were determined in various groups.. The lung and intestinal injury in AMG was more serious than that in the YMG. The decreases in SOD activity and 6-keto-PGF(1alpha) content, the increases in contents of TXB(2), NO, MDA in the YMG and the AMG were obvious than those in the YCG and the ACG respectively. The decrease in SOD activity and increase in MDA content were obvious in the ACG than those in the YCG. In addition, the decrease in SOD activity and increase in MDA content in the AMG were significant compared with those in the YMG.. The Prostaglandin metabolism and the free radical injury might be in the pathogenesis of intestinal injury in the aged rats with pneumonia. The intestinal injury induced by free radical in aged rats with pneumonia appears to be more obvious with ageing. Topics: 6-Ketoprostaglandin F1 alpha; Aging; Animals; Free Radicals; Intestinal Mucosa; Lung; Male; Malondialdehyde; Nitric Oxide; Pneumonia, Pneumococcal; Prostaglandins; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thromboxane B2 | 2003 |
Comparison of regional pulmonary perfusion in lobar pneumonia during high frequency and conventional mechanical ventilation in sheep.
We compared the effects of high frequency jet ventilation (HFV), conventional ventilation (CMV), and spontaneous breathing (SB) on regional pulmonary blood flows (QLLL), standard cardiopulmonary measurements and the serum levels of the first generation metabolites of prostacyclin (6-keto-PGF1 alpha) and thromboxane A2 (TxB2) in established left lower lobe pseudomonas aeruginosa pneumonia in 11 sheep. Gram negative pneumonia resulted in significant increases in alveolar-arterial oxygen gradients [(A-a)DO2] and pulmonary shunt fractions (Qs/Qt), as well as a significant decrease in QLLL during SB. Significant differences in standard haemodynamics, (A-a)DO2, Qs/Qt, and QLLL were not observed when HFV was compared to CMV. However, serum levels of 6-keto-PGF1 alpha were elevated when the animals underwent HFV. We conclude that HFV is a safe and efficient method of oxygenation and ventilation in unilobar gram negative pneumonia and also results in a significant increase in the serum levels of 6-keto-PGF1 alpha when compared to CMV in sheep. The exact significance of the latter finding is the subject of current investigation. Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cardiac Output; Female; Hemodynamics; Pneumonia, Pneumococcal; Pseudomonas Infections; Pulmonary Circulation; Respiration; Respiration, Artificial; Sheep; Thromboxane B2 | 1987 |