6-ketoprostaglandin-f1-alpha has been researched along with Mitral-Valve-Stenosis* in 2 studies
2 other study(ies) available for 6-ketoprostaglandin-f1-alpha and Mitral-Valve-Stenosis
Article | Year |
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Left atrial endocardium and prostacyclin.
In patients with rheumatic mitral stenosis, intracardiac thrombi are found mostly, for reasons still unknown, in the left atrium. We compared the release of PGI2 from the endocardium of the left atrium with that of the right ventricle and from the endothelium of the pulmonary arteries. Endocardial endothelial cells (EECs) were isolated from right ventricles (RV) and left atrial appendages (LAA) of porcine hearts, and vascular endothelial cells (VECs) from pulmonary arteries (PA) were obtained from the same animals. Cultured EEC and PA-VEC monolayers were placed in a pressure loading apparatus and incubated for 30 min under various pressures. After incubation, the supernatants were sampled and the 6-keto-PGF1 alpha contents measured. PGI2 release from LAA-EEC was much less than from RV-EEC or from PA-VEC. Moreover, transmural pressure did not enhance PGI2 release from LAA-EEC, although it did from RV-EEC and PA-EEC in a pressure-dependent manner. These results may explain why the left atrium is a common site for intracardiac thrombus formation in patients with mitral valve disease. Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cells, Cultured; Endocardium; Endothelium, Vascular; Epoprostenol; Heart Atria; Heart Ventricles; Humans; Mitral Valve Stenosis; Pressure; Pulmonary Artery; Swine; Thrombosis | 1999 |
[Changes in plasma TXB2 and 6-keto-PGF1 alpha and left atrial thrombosis in mitral stenosis].
This study was performed to determine the relationship between plasma concentration of thromboxane B2 (TXB2), 6-keto-prostaglandin F1a and atrial thrombosis in patients with mitral stenosis (MS). By radioimmunoassay and pathological examination, peripheral plasma TXB2 level was remarkably higher in patients with MS and persistent atrial fibrillation (AF) than in patients with MS but without AF (P less than 0.01). Plasma TXB2 level was significantly higher in patients with than in those without atrial thrombosis (P less than 0.05). There was no significant difference in plasma 6-keto-PGF1 alpha, plasma prostanoids level in peripheral venous blood correlated closely with that in left atrial blood. Patients with high plasma TXB2 level had a greater incidence of microthrombosis. Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Atrial Fibrillation; Female; Heart Diseases; Humans; Male; Middle Aged; Mitral Valve Stenosis; Rheumatic Heart Disease; Thrombosis; Thromboxane B2 | 1990 |