6-ketoprostaglandin-f1-alpha and Hemorrhagic-Fever-with-Renal-Syndrome

In this paper, the model of rat infected EHFV was made and the influence of moxibustion on TXA2 and PGI2 in its plasma was observed. The results show that the content of TXA2 increased and PGI2 decreased in rat significantly after the abdominal inoculation of EHFV, and the content of TXA2 decreased and PGI2 increased markedly in rat infected EHFV to normal level after treatment with moxibustion, suggesting that the regulative function of moxibustion on TXA2 and PGI2 is one of its nerve-endocrine-immune regulations to the body, and there is an important significance. This study provides an important reference for mechanism exploration of moxibustion preventing and treating EHF.

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Female; Hemorrhagic Fever with Renal Syndrome; Male; Moxibustion; Rats; Rats, Inbred Strains; Thromboxane B2

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Biogenic Monoamines; Dopamine; Female; Hemorrhagic Fever with Renal Syndrome; Male; Norepinephrine; Rats; Rats, Wistar; Thromboxane B2

Plasma concentrations of Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were dynamically measured with radioimmunoassay in 30 patients of epidemic hemorrhagic fever (EHF). It was found that the levels plasma TXB2 significantly increased and 6-keto-PGF1 alpha decreased in EHF patients as compared with those in controls. The more severe the patient's condition, the higher the level of TXB2 and the lower the level of 6-keto-PGF1 alpha. The ratio of TXB2/6-keto-PGF1 alpha was parallel with the severity of the patient's condition. Plasma TXB and TXB2/6-keto-PGF1 alpha ratio increased significantly in the hemorrhagic and shock group, while 6-keto-PGF1 alpha decreased significantly in the shock group. The results showed that there is a distinct imbalance of TXA2-PGI2 mediated through the increase of TXA2 and decrease of PGI2 in EHF. The imbalance of TXA2-PGI2 participates in the pathogenesis and pathophysiology of hemorrhage, shock and renal dysfunction.

Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Hemorrhagic Fever with Renal Syndrome; Humans; Middle Aged; Thromboxane B2

Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Hemorrhagic Fever with Renal Syndrome; Humans; Middle Aged; Thromboxane B2