6-ketoprostaglandin-f1-alpha has been researched along with Heart-Septal-Defects--Ventricular* in 1 studies
1 trial(s) available for 6-ketoprostaglandin-f1-alpha and Heart-Septal-Defects--Ventricular
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[Effects in tetramethylpyrazine on TXA2 and PGI2 by cardio-pulmonary bypass in congenital heart diseases with pulmonary hypertension patients].
To study protective effects of tetramethylpyrazine (TMP) on the imbalance of TXA2/PGI2 during cardiopulmomary bypass (CPB) in congenital heart disease (CHD) with pulmonary hypertension (PH) patients.. Thirty patients suffered from non-cyanotic CHD-PH were randomly divided into control group (n = 15) and treatment group (n = 15). 3 mg/kg of TMP was dripped intravenously after anesthesia and 1 mg/kg of TMP was infused into oxygenator after CPB individually. Blood samples were collected and TXA2 as well as PGI2 were measured after anesthesia induction, 15 min during CPB, 5 min after release of the aortic cross-clamp, and 20 min, 6 hrs and 24 hrs after CPB.. There was significant difference between treatment group and control group except before operation and 24 hrs after CPB.. The imbalance of TXA2 and PGI2 in patients with CHD-PH during CPB could correct by TMP. Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Cardiopulmonary Bypass; Child; Child, Preschool; Female; Heart Septal Defects, Atrial; Heart Septal Defects, Ventricular; Humans; Hypertension, Pulmonary; Male; Pyrazines; Thromboxane B2; Vasodilator Agents | 1998 |