6-ketoprostaglandin-f1-alpha and Facial-Neoplasms

The diagnosis of secondary or recurrent tumour growth after operations on primary maxillo-facial tumours is still only possible at a late stage. On the other hand, the prostaglandins of the E series assume an important role in connection with tumour growth. The present investigation succeeded for the first time in detecting an increase in the level of 6-oxo-PGF1 alpha, the stable metabolite of PGI2, before planned radical operation in patients with maxillo-facial tumours. In the further course of the illness it was possible to establish a correlation between the plasma values and the occurrence of metastasis or recurrence of disease. These results indicate that a certain significance can be attributed to 6-oxo-PGF1 alpha as a tumour marker.

Topics: 6-Ketoprostaglandin F1 alpha; Facial Neoplasms; Female; Humans; Jaw Neoplasms; Male; Neoplasm Recurrence, Local