6-ketoprostaglandin-f1-alpha and Apnea

6-ketoprostaglandin-f1-alpha has been researched along with Apnea* in 1 studies

Other Studies

1 other study(ies) available for 6-ketoprostaglandin-f1-alpha and Apnea

ArticleYear
Reduced prostacyclin to thromboxane A2 ratio is correlated with central apneas in preterm infants.
    Prostaglandins & other lipid mediators, 1999, Volume: 58, Issue:5-6

    Prostacyclin has a vasodilating effect on pulmonary vessels, whereas thromboxane A2 results in vasoconstriction. This study was designed to test the hypothesis that recurrent central apneas in preterm infants are correlated with a reduced prostacyclin to thromboxane A2 ratio. Twelve preterm infants with clinical events of apneas were matched with 12 control infants. Urinary concentration of 2,3-dinor-6-keto-PGF1alpha and 2,3-dinor-TxB2 was determined, and the ratio correlated with the number of central apneas (>20s) measured in overnight polygraphy. The number of central apneas >20s/12h was 97.4 (SE 7.8) in the study group, and 47.3 (SE 6.6) in the control group (p = 0.001). There was a significant correlation between the number of central apneas and the 2,3-dinor-6-keto-PGF1alpha/2,3-dinor-TxB2-ratio in all infants combined (r = -0.72, p < 0.0001) as well as in the two subject groups. Central apneas in premature infants are correlated with an decreased prostacyclin to thromboxane A2 ratio. The underlying pathomechanism may be increased intrapulmonary shunts with reflexive central apneas due to reduced pulmonary oxygenation.

    Topics: 6-Ketoprostaglandin F1 alpha; Apnea; Birth Weight; Epoprostenol; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Polysomnography; Prostaglandins F; Thromboxane A2; Thromboxane B2

1999