6-ketoprostaglandin-e1 has been researched along with Seizures* in 1 studies
1 other study(ies) available for 6-ketoprostaglandin-e1 and Seizures
| Article | Year |
|---|---|
Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils.
Basal levels of 5 cerebral prostanoids (PGD2, PGF2 alpha, PGE2, 6-keto-PGF1 alpha and thromboxane/TX/B2) were measured radioimmunologically in normal and convulsion-prone gerbils. Significantly less PGD2,PGE2 and 6-keto-PGF1 alpha was found in the brain of seizure-sensitive animals. After treatment with indomethacin, which reduced the amount of brain cyclo-oxygenase products, also normal gerbils exhibited convulsions following environmental stress. The results are in accordance with the hypothesis that endogenous prostanoids play a role in the regulation of seizure susceptibility. Topics: Alprostadil; Animals; Brain; Brain Chemistry; Dinoprost; Dinoprostone; Disease Susceptibility; Female; Gerbillinae; Male; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins D; Prostaglandins E; Prostaglandins F; Seizures; Thromboxane B2 | 1984 |